{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:30:51Z","timestamp":1786120251540,"version":"build-2736575974"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1097\/aci.0b013e32834c233a","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T19:20:45Z","timestamp":1317756045000},"page":"517-524","source":"Crossref","is-referenced-by-count":45,"title":["T-cell receptor excision circles in primary immunodeficiencies and other T-cell immune disorders"],"prefix":"10.1097","volume":"11","author":[{"given":"Raz","family":"Somech","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20210128","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/01.GIM.0000105752.80592.A3","article-title":"Mutations in genes required for T-cell development:IL7R, CD45, IL2RG, JAK3,RAG1, RAG2, ARTEMIS, and ADA and severe combined immunodeficiency: HuGE review.","volume":"6","author":"Kalman","year":"2004","journal-title":"Genet Med"},{"key":"R2-5-20210128","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1203\/PDR.0b013e3181c6e554","article-title":"Molecular assessment of thymus capabilities in the evaluation of T-cell immunodeficiency.","volume":"67","author":"Amariglio","year":"2010","journal-title":"Pediatr Res"},{"key":"R3-5-20210128","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S1074-7613(00)80056-4","article-title":"Generation of functional thymocytes in the human adult.","volume":"10","author":"Jamieson","year":"1999","journal-title":"Immunity"},{"key":"R4-5-20210128","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-59745-395-0_12","article-title":"Estimating thymic function through quantification of T-cell receptor excision circles.","volume":"380","author":"Dion","year":"2007","journal-title":"Methods Mol Biol"},{"key":"R5-5-20210128","first-page":"96","article-title":"Thymic function-related markers within the thymus and peripheral blood: are they comparable J Clin I","volume":"26","author":"Arellano","year":"2006","journal-title":"mmunol"},{"key":"R6-5-20210128","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1097\/TP.0b013e31820b6b52","article-title":"Quantification of baboon thymopoiesis in porcine thymokidney xenografts by the signal-joining T-cell receptor excision circle assay.","volume":"91","author":"Tena","year":"2011","journal-title":"Transplantation"},{"key":"R8-5-20210128","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1084\/jem.20060964","article-title":"Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion.","volume":"204","author":"van Zelm","year":"2007","journal-title":"J Exp Med"},{"key":"R9-5-20210128","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.clim.2010.04.005","article-title":"Simultaneous quantification of recent thymic T-cell and bone marrow B-cell emigrants in patients with primary immunodeficiency undergone to stem cell transplantation.","volume":"136","author":"Sottini","year":"2010","journal-title":"Clin Immunol"},{"key":"R10-5-20210128","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s001090100271","article-title":"T cell receptor excision circles as markers for recent thymic emigrants: basic aspects, technical approach, and guidelines for interpretation.","volume":"79","author":"Hazenberg","year":"2001","journal-title":"J Mol Med"},{"key":"R11-5-20210128","doi-asserted-by":"crossref","first-page":"4215","DOI":"10.1073\/pnas.070061597","article-title":"Identification of a human recent thymic emigrant phenotype.","volume":"97","author":"McFarland","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R12-5-20210128","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/25374","article-title":"Changes in thymic function with age and during the treatment of HIV infection.","volume":"396","author":"Douek","year":"1998","journal-title":"Nature"},{"key":"R13-5-20210128","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1056\/NEJM200007063430107","article-title":"The immune system. First of two parts.","volume":"343","author":"Delves","year":"2000","journal-title":"N Engl J Med"},{"key":"R14-5-20210128","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1084\/jem.20042524","article-title":"New insights on human T cell development by quantitative T cell receptor gene rearrangement studies and gene expression profiling.","volume":"201","author":"Dik","year":"2005","journal-title":"J Exp Med"},{"key":"R15-5-20210128","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1600-065X.2006.00493.x","article-title":"Determining thymic output quantitatively: using models to interpret experimental T-cell receptor excision circle (TREC) data.","volume":"216","author":"Ribeiro","year":"2007","journal-title":"Immunol Rev"},{"key":"R16-5-20210128","doi-asserted-by":"crossref","first-page":"4329","DOI":"10.4049\/jimmunol.0900743","article-title":"Quantifying thymic export: combining models of naive T cell proliferation and TCR excision circle dynamics gives an explicit measure of thymic output.","volume":"183","author":"Bains","year":"2009","journal-title":"J Immunol"},{"key":"R17-5-20210128","doi-asserted-by":"crossref","first-page":"e465","DOI":"10.1542\/peds.2009-3659","article-title":"Why newborn screening for severe combined immunodeficiency is essential: a case report.","volume":"126","author":"Adeli","year":"2010","journal-title":"Pediatrics"},{"key":"R18-5-20210128","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clim.2010.09.010","article-title":"Early vs. delayed diagnosis of severe combined immunodeficiency: a family perspective survey.","volume":"138","author":"Chan","year":"2011","journal-title":"Clin Immunol"},{"key":"R19-5-20210128","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1182\/blood-2010-08-300384","article-title":"Neonatal diagnosis of severe combined immunodeficiency leads to significantly improved survival outcome: the case for newborn screening.","volume":"117","author":"Brown","year":"2011","journal-title":"Blood"},{"key":"R20-5-20210128","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ymgme.2005.09.005","article-title":"Two-tiered universal newborn screening strategy for severe combined immunodeficiency.","volume":"86","author":"McGhee","year":"2005","journal-title":"Mol Genet Metab"},{"key":"R21-5-20210128","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jaci.2004.10.012","article-title":"Development of population-based newborn screening for severe combined immunodeficiency.","volume":"115","author":"Chan","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"R22-5-20210128","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jaci.2009.04.007","article-title":"Development of a routine newborn screening protocol for severe combined immunodeficiency.","volume":"124","author":"Baker","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"R23-5-20210128","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jpeds.2009.05.026","article-title":"Identification of severe combined immunodeficiency by T-cell receptor excision circles quantification using neonatal Guthrie cards.","volume":"155","author":"Morinishi","year":"2009","journal-title":"J Pediatr"},{"key":"R24-5-20210128","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1001\/jama.2009.1806","article-title":"Statewide newborn screening for severe T- cell lymphopenia.","volume":"302","author":"Routes","year":"2009","journal-title":"J Am Med Assoc"},{"key":"R26-5-20210128","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1365-2249.2010.04152.x","article-title":"Low thymic output in the 22q11.2 deletion syndrome measured by CCR9CD45RA T cell counts and T cell receptor rearrangement excision circles.","volume":"161","author":"Lima","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"R28-5-20210128","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1046\/j.1365-2249.2002.01893.x","article-title":"Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles.","volume":"129","author":"Guazzi","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"R29-5-20210128","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S1081-1206(10)61416-0","article-title":"Assessing thymopoiesis in patients with common variable immunodeficiency as measured by T-cell receptor excision circles.","volume":"93","author":"De Vera","year":"2004","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R30-5-20210128","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.jaci.2009.06.048","article-title":"Reduced central tolerance in Omenn syndrome leads to immature self-reactive oligoclonal T cells.","volume":"124","author":"Somech","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"R31-5-20210128","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.jaci.2010.07.029","article-title":"Characterization of -associated protein, 70 kd (ZAP70)-deficient human lymphocytes.","volume":"126","author":"Roifman","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"R32-5-20210128","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2249.2010.04209.x","article-title":"Tracing thymic output in older individuals.","volume":"161","author":"Mitchell","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"R33-5-20210128","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00414-010-0528-3","article-title":"Detection and quantification of the age-related sjTREC decline in human peripheral blood.","volume":"125","author":"Ou","year":"2011","journal-title":"Int J Legal Med"},{"key":"R34-5-20210128","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1046\/j.1365-2249.2001.01640.x","article-title":"Both age and gender affect thymic output: more recent thymic migrants in females than males as they age.","volume":"125","author":"Pido-Lopez","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"R35-5-20210128","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/ard.2008.088112","article-title":"Thymic function in juvenile idiopathic arthritis.","volume":"68","author":"Lorenzi","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"R36-5-20210128","first-page":"348","article-title":"Decreased recent thymus emigrant number in rheumatoid factor-negative polyarticular juvenile idiopathic arthritis.","volume":"28","author":"Horvath","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"R37-5-20210128","first-page":"1762","article-title":"Decreased recent thymus emigrant number is associated with disease activity in systemic lupus erythematosus.","volume":"35","author":"Vieira","year":"2008","journal-title":"J Rheumatol"},{"key":"R38-5-20210128","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jneuroim.2010.12.007","article-title":"Reduced thymic output and peripheral naive CD4 T-cell alterations in primary progressive multiple sclerosis (PPMS).","volume":"233","author":"Haegert","year":"2011","journal-title":"J Neuroimmunol"},{"key":"R39-5-20210128","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2249.2010.04230.x","article-title":"Rapid migration of thymic emigrants to the colonic mucosa in ulcerative colitis patients.","volume":"162","author":"Elgbratt","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"R40-5-20210128","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1097\/TP.0b013e3181af653c","article-title":"Immunological senescence and thymic function in transplantation.","volume":"88","author":"Pujol-Borrell","year":"2009","journal-title":"Transplantation"},{"key":"R41-5-20210128","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/sj.bmt.1705557","article-title":"T cell regeneration in pediatric allogeneic stem cell transplantation.","volume":"39","author":"Olkinuora","year":"2007","journal-title":"Bone Marrow Transplant"},{"key":"R42-5-20210128","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1097\/00007890-200204150-00026","article-title":"Factors influencing T-lymphopoiesis after allogeneic hematopoietic cell transplantation.","volume":"73","author":"Storek","year":"2002","journal-title":"Transplantation"},{"key":"R43-5-20210128","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1182\/blood.V98.4.1116","article-title":"Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation in adults.","volume":"98","author":"Hochberg","year":"2001","journal-title":"Blood"},{"key":"R44-5-20210128","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.3324\/haematol.2010.025098","article-title":"Role of reduced intensity conditioning in T-cell and B-cell immune reconstitution after HLA-identical bone marrow transplantation in ADA-SCID.","volume":"95","author":"Cancrini","year":"2010","journal-title":"Haematologica"},{"key":"R45-5-20210128","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1756-8722-4-19","article-title":"Frequency analysis of TRBV subfamily sjTRECs to characterize T-cell reconstitution in acute leukemia patients after allogeneic hematopoietic stem cell transplantation.","volume":"4","author":"Wu","year":"2011","journal-title":"J Hematol Oncol"},{"key":"R46-5-20210128","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1182\/blood-2008-09-177840","article-title":"Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease.","volume":"113","author":"Sarantopoulos","year":"2009","journal-title":"Blood"},{"key":"R47-5-20210128","doi-asserted-by":"crossref","first-page":"6107","DOI":"10.1158\/1078-0432.CCR-07-1290","article-title":"High levels of B-cell activating factor in patients with active chronic graft-versus-host disease.","volume":"13","author":"Sarantopoulos","year":"2007","journal-title":"Clin Cancer Res"},{"key":"R48-5-20210128","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.4049\/jimmunol.170.5.2711","article-title":"T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation.","volume":"170","author":"Sarzotti","year":"2003","journal-title":"J Immunol"},{"key":"R49-5-20210128","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jaci.2006.01.013","article-title":"Association of CD4 T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy.","volume":"117","author":"Saitoh","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"R50-5-20210128","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/01.COH.0000194105.12816.6a","article-title":"Estimating the role of thymic output in HIV infection.","volume":"1","author":"De Boer","year":"2006","journal-title":"Curr Opin HIV AIDS"},{"key":"R51-5-20210128","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jaci.2008.04.029","article-title":"Antiretroviral therapy corrects HIV-1-induced expansion of CD8 CD45RA CD2-) CD11a(bright) activated T cells.","volume":"122","author":"Yin","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"R52-5-20210128","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1365-2249.2007.03526.x","article-title":"Immune reconstitution in human immunodeficiency virus type 1-infected children with different virological responses to antiretroviral therapy.","volume":"150","author":"Anselmi","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"R53-5-20210128","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1097\/QAD.0b013e3283303307","article-title":"Improved thymic index, density and output in HIV-infected patients following low-dose growth hormone therapy: a placebo controlled study.","volume":"23","author":"Hansen","year":"2009","journal-title":"AIDS"},{"key":"R54-5-20210128","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1471-2334-6-112","article-title":"Different profiles of immune reconstitution in children and adults with HIV-infection after highly active antiretroviral therapy.","volume":"6","author":"Resino","year":"2006","journal-title":"BMC Infect Dis"}],"container-title":["Current Opinion in Allergy &amp; Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/ACI.0b013e32834c233a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:20:16Z","timestamp":1786047616000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00130832-201112000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/aci.0b013e32834c233a","relation":{},"ISSN":["1528-4050"],"issn-type":[{"value":"1528-4050","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}