{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:12:48Z","timestamp":1791443568063,"version":"4.3.3"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1097\/aci.0b013e3283574d0c","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T07:15:03Z","timestamp":1344582903000},"page":"477-484","source":"Crossref","is-referenced-by-count":77,"title":["The role of interleukin-1 in allergy-related disorders"],"prefix":"10.1097","volume":"12","author":[{"given":"Karoline","family":"Krause","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Metz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Makris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Zuberbier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Maurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20210128","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1084\/jem.136.1.128","article-title":"Potentiation of the T-lymphocyte response to mitogens. I. The responding cell.","volume":"136","author":"Gery","year":"1972","journal-title":"J Exp Med"},{"key":"R2-8-20210128","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1084\/jem.136.1.143","article-title":"Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).","volume":"136","author":"Gery","year":"1972","journal-title":"J Exp Med"},{"key":"R3-8-20210128","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.1073\/pnas.74.10.4624","article-title":"Human leukocytic pyrogen: purification and development of a radioimmunoassay.","volume":"74","author":"Dinarello","year":"1977","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R4-8-20210128","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev.immunol.021908.132612","article-title":"Immunological and inflammatory functions of the interleukin-1 family.","volume":"27","author":"Dinarello","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"R5-8-20210128","first-page":"583","article-title":"Phase I study of recombinant human interleukin-1 beta (rhIL-1 beta) in patients with bone marrow failure.","volume":"14","author":"Nemunaitis","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"R6-8-20210128","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1200\/JCO.1994.12.4.707","article-title":"Effects of interleukin-1 alpha on carboplatin-induced thrombocytopenia in patients with recurrent ovarian cancer.","volume":"12","author":"Vadhan-Raj","year":"1994","journal-title":"J Clin Oncol"},{"key":"R7-8-20210128","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095","article-title":"Biologic basis for interleukin-1 in disease.","volume":"87","author":"Dinarello","year":"1996","journal-title":"Blood"},{"key":"R8-8-20210128","doi-asserted-by":"crossref","first-page":"7803","DOI":"10.1073\/pnas.0802726105","article-title":"A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide.","volume":"105","author":"Hsu","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R9-8-20210128","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature07965","article-title":"Syk kinase signalling couples to the Nlrp3 inflammasome for antifungal host defence.","volume":"459","author":"Gross","year":"2009","journal-title":"Nature"},{"key":"R10-8-20210128","doi-asserted-by":"crossref","first-page":"36560","DOI":"10.1074\/jbc.M607594200","article-title":"Critical role for CryopyrinNalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA.","volume":"281","author":"Kanneganti","year":"2006","journal-title":"J Biol Chem"},{"key":"R11-8-20210128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2011.04440.x","article-title":"The NLRP3 inflammasome in health and disease: the good, the bad and the ugly.","volume":"166","author":"Menu","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"R12-8-20210128","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJMoa055137","article-title":"Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition.","volume":"355","author":"Goldbach-Mansky","year":"2006","journal-title":"N Engl J Med"},{"key":"R13-8-20210128","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3899\/jrheum.100718","article-title":"Antiinterleukin 1 treatment for patients with familial Mediterranean fever resistant to colchicine.","volume":"38","author":"Ozen","year":"2011","journal-title":"J Rheumatol"},{"key":"R15-8-20210128","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/ard.2010.134254","article-title":"A multicentre, randomised, double-blind, placebo-controlled trial with the interleukin-1 receptor antagonist anakinra in patients with systemic-onset juvenile idiopathic arthritis (ANAJIS trial).","volume":"70","author":"Quartier","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"R16-8-20210128","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1002\/art.33412","article-title":"Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial.","volume":"64","author":"Schumacher","year":"2012","journal-title":"Arthritis Rheum"},{"key":"R17-8-20210128","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1172\/JCI200215318","article-title":"Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.","volume":"110","author":"Maedler","year":"2002","journal-title":"J Clin Invest"},{"key":"R18-8-20210128","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.1074\/jbc.M109.064907","article-title":"Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta.","volume":"285","author":"Okamoto","year":"2010","journal-title":"J Biol Chem"},{"key":"R19-8-20210128","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1084\/jem.20082179","article-title":"Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria.","volume":"206","author":"Nakamura","year":"2009","journal-title":"J Exp Med"},{"key":"R20-8-20210128","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.pharmthera.2011.03.007","article-title":"The role of the NLRP3 inflammasome in the pathogenesis of airway disease.","volume":"130","author":"Birrell","year":"2011","journal-title":"Pharmacol Ther"},{"key":"R21-8-20210128","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1038\/sj.jid.5700819","article-title":"Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity.","volume":"127","author":"Watanabe","year":"2007","journal-title":"J Invest Dermatol"},{"key":"R22-8-20210128","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.jaci.2010.12.006","article-title":"Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes.","volume":"127","author":"Dai","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"R23-8-20210128","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-065X.2011.01042.x","article-title":"Deregulated inflammasome signaling in disease.","volume":"243","author":"Lamkanfi","year":"2011","journal-title":"Immunol Rev"},{"key":"R24-8-20210128","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.4049\/jimmunol.1002720","article-title":"Differential expression of NLRP3 among hematopoietic cells.","volume":"186","author":"Guarda","year":"2011","journal-title":"J Immunol"},{"key":"R25-8-20210128","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol Cell"},{"key":"R26-8-20210128","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature06664","article-title":"The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response.","volume":"452","author":"Muruve","year":"2008","journal-title":"Nature"},{"key":"R27-8-20210128","doi-asserted-by":"crossref","first-page":"e1001191","DOI":"10.1371\/journal.ppat.1001191","article-title":"Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.","volume":"6","author":"McNeela","year":"2010","journal-title":"PLoS Pathog"},{"key":"R28-8-20210128","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome.","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"R29-8-20210128","doi-asserted-by":"crossref","first-page":"8041","DOI":"10.1073\/pnas.0611496104","article-title":"CryopyrinNALP3 binds ATPdATP, is an ATPase, and requires ATP binding to mediate inflammatory signaling.","volume":"104","author":"Duncan","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R30-8-20210128","doi-asserted-by":"crossref","first-page":"19449","DOI":"10.1073\/pnas.1008155107","article-title":"Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1alpha and IL-1beta.","volume":"107","author":"Yazdi","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R31-8-20210128","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/ng756","article-title":"Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome.","volume":"29","author":"Hoffman","year":"2001","journal-title":"Nat Genet"},{"key":"R32-8-20210128","first-page":"25","article-title":"Nat G","volume":"17","year":"1997","journal-title":"enet"},{"key":"R33-8-20210128","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/9696","article-title":"Mutations in the gene encoding mevalonate kinase cause hyper-IgD and periodic fever syndrome. International Hyper-IgD Study Group.","volume":"22","author":"Drenth","year":"1999","journal-title":"Nat Genet"},{"key":"R34-8-20210128","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1056\/NEJMoa0807865","article-title":"An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist.","volume":"360","author":"Aksentijevich","year":"2009","journal-title":"N Engl J Med"},{"key":"R35-8-20210128","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.cell.2010.03.002","article-title":"Autoinflammatory disease reloaded: a clinical perspective.","volume":"140","author":"Kastner","year":"2010","journal-title":"Cell"},{"key":"R36-8-20210128","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0092-8674(00)80721-7","article-title":"Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.","volume":"97","author":"McDermott","year":"1999","journal-title":"Cell"},{"key":"R37-8-20210128","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/eji.201141550","article-title":"A clinical perspective of IL-1beta as the gatekeeper of inflammation.","volume":"41","author":"Dinarello","year":"2011","journal-title":"Eur J Immunol"},{"key":"R38-8-20210128","doi-asserted-by":"crossref","first-page":"e297","DOI":"10.1371\/journal.pmed.0030297","article-title":"A proposed classification of the immunological diseases.","volume":"3","author":"McGonagle","year":"2006","journal-title":"PLoS Med"},{"key":"R39-8-20210128","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1398-9995.2009.02179.x","article-title":"EAACIGA(2)LENEDFWAO guideline: definition, classification and diagnosis of urticaria.","volume":"64","author":"Zuberbier","year":"2009","journal-title":"Allergy"},{"key":"R40-8-20210128","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/art.23687","article-title":"Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.","volume":"58","author":"Hoffman","year":"2008","journal-title":"Arthritis Rheum"},{"key":"R41-8-20210128","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1056\/NEJMoa0810787","article-title":"Use of canakinumab in the cryopyrin-associated periodic syndrome.","volume":"360","author":"Lachmann","year":"2009","journal-title":"N Engl J Med"},{"key":"R42-8-20210128","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1136\/ard.2011.152728","article-title":"Two-year results from an open-label, multicentre, phase III study evaluating the safety and efficacy of canakinumab in patients with cryopyrin-associated periodic syndrome across different severity phenotypes.","volume":"70","author":"Kuemmerle-Deschner","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"R43-8-20210128","doi-asserted-by":"crossref","first-page":"R202","DOI":"10.1186\/ar3535","article-title":"Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study.","volume":"13","author":"Kone-Paut","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"R44-8-20210128","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1093\/rheumatology\/kep222","article-title":"Dysfunctional inflammasome in Schnitzlers syndrome.","volume":"48","author":"Pizzirani","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"R46-8-20210128","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.semarthrit.2007.04.001","article-title":"Schnitzler syndrome: beyond the case reports: review and follow-up of 94 patients with an emphasis on prognosis and treatment.","volume":"37","author":"de Koning","year":"2007","journal-title":"Semin Arthritis Rheum"},{"key":"R48-8-20210128","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cyto.2005.07.011","article-title":"Cytokines and Langerhans cell mobilisation in mouse and man.","volume":"32","author":"Griffiths","year":"2005","journal-title":"Cytokine"},{"key":"R49-8-20210128","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1084\/jem.20092489","article-title":"Lack of the purinergic receptor P2X(7) results in resistance to contact hypersensitivity.","volume":"207","author":"Weber","year":"2010","journal-title":"J Exp Med"},{"key":"R50-8-20210128","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.4049\/jimmunol.1100928","article-title":"IL-1 receptor signaling is required at multiple stages of sensitization and elicitation of the contact hypersensitivity response.","volume":"188","author":"Kish","year":"2012","journal-title":"J Immunol"},{"key":"R51-8-20210128","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/1523-1747.ep12320329","article-title":"Interleukin-1 receptor antagonist suppresses contact hypersensitivity.","volume":"105","author":"Kondo","year":"1995","journal-title":"J Invest Dermatol"},{"key":"R52-8-20210128","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.cub.2007.05.074","article-title":"The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes.","volume":"17","author":"Feldmeyer","year":"2007","journal-title":"Curr Biol"},{"key":"R53-8-20210128","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000323963","article-title":"Modifications of the innate immune system in atopic dermatitis.","volume":"3","author":"Maintz","year":"2011","journal-title":"J Innate Immun"},{"key":"R54-8-20210128","doi-asserted-by":"crossref","first-page":"3942","DOI":"10.4049\/jimmunol.0900729","article-title":"A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome.","volume":"183","author":"Munoz-Planillo","year":"2009","journal-title":"J Immunol"},{"key":"R55-8-20210128","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/intimm\/dxg054","article-title":"IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response.","volume":"15","author":"Nakae","year":"2003","journal-title":"Int Immunol"},{"key":"R56-8-20210128","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/eji.200323801","article-title":"The IL-1 receptor 1 is critical for Th2 cell type airway immune responses in a mild but not in a more severe asthma model.","volume":"33","author":"Schmitz","year":"2003","journal-title":"Eur J Immunol"},{"key":"R57-8-20210128","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1398-9995.2011.02586.x","article-title":"NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant.","volume":"66","author":"Besnard","year":"2011","journal-title":"Allergy"},{"key":"R58-8-20210128","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.jaci.2009.07.044","article-title":"Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma.","volume":"124","author":"Hitomi","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"R59-8-20210128","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1038\/sj.gt.3302798","article-title":"Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma.","volume":"13","author":"Wang","year":"2006","journal-title":"Gene Ther"},{"key":"R60-8-20210128","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/S0091-6749(95)70081-1","article-title":"Potential role of interleukin-1 in allergen-induced late asthmatic reactions in guinea pigs: suppressive effect of interleukin-1 receptor antagonist on late asthmatic reaction.","volume":"95","author":"Okada","year":"1995","journal-title":"J Allergy Clin Immunol"},{"key":"R61-8-20210128","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1254\/jphs.FPJ06007X","article-title":"Pharmacokinetics and antiasthmatic potential of nonparenterally administered recombinant human interleukin-1 receptor antagonist in animal models.","volume":"102","author":"Li","year":"2006","journal-title":"J Pharmacol Sci"},{"key":"R62-8-20210128","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.jaci.2005.07.008","article-title":"Prevention of IL-1 signaling attenuates airway hyperresponsiveness and inflammation in a murine model of toluene diisocyanate-induced asthma.","volume":"116","author":"Johnson","year":"2005","journal-title":"J Allergy Clin Immunol"}],"container-title":["Current Opinion in Allergy & Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/ACI.0b013e3283574d0c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T16:51:00Z","timestamp":1636563060000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00130832-201210000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":59,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/aci.0b013e3283574d0c","relation":{},"ISSN":["1528-4050"],"issn-type":[{"value":"1528-4050","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}