{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:19:38Z","timestamp":1792088378744,"version":"4.4.0"},"reference-count":64,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1097\/aci.0b013e328357a21b","type":"journal-article","created":{"date-parts":[[2012,8,10]],"date-time":"2012-08-10T07:15:03Z","timestamp":1344582903000},"page":"534-539","source":"Crossref","is-referenced-by-count":47,"title":["Molecular immunology of allergic conjunctivitis"],"prefix":"10.1097","volume":"12","author":[{"given":"Murat T.","family":"Irkec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banu","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20210128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.iac.2007.12.011","article-title":"Ocular allergy overview.","volume":"28","author":"Bielory","year":"2008","journal-title":"Immunol Allergy Clin North Am"},{"key":"R2-16-20210128","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jaci.2004.10.042","article-title":"Allergic conjunctivitis: update on pathophysiology and prospects for future treatment.","volume":"115","author":"Ono","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"R3-16-20210128","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.clae.2008.07.003","article-title":"The pathophysiology of ocular allergy: a review.","volume":"32","author":"Chigbu","year":"2009","journal-title":"Contact Lens Anterior Eye"},{"key":"R4-16-20210128","first-page":"1280","article-title":"Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis.","volume":"16","author":"Ishida","year":"2010","journal-title":"Mol Vis"},{"key":"R5-16-20210128","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2500\/aap.2007.28.3011","article-title":"The pathophysiology of allergic rhinoconjunctivitis.","volume":"28","author":"Broide","year":"2007","journal-title":"Allergy Asthma Proc"},{"key":"R6-16-20210128","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1038\/eye.2008.372","article-title":"Characterisation of dendritic cell phenotype in allergic conjunctiva: increased expression of FcRI, the high affinity receptor for immunoglobulin E.","volume":"23","author":"Manzouri","year":"2009","journal-title":"Eye"},{"key":"R8-16-20210128","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1046\/j.1365-2222.2001.00970.x","article-title":"The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus.","volume":"31","author":"Wan","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"R9-16-20210128","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/j.1440-1843.2007.01175.x","article-title":"Pollen proteolytic enzymes degrade tight junctions.","volume":"12","author":"Runswick","year":"2007","journal-title":"Respirology"},{"key":"R10-16-20210128","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-4419-8056-4_5","article-title":"The role of histamine in ocular allergy.","volume":"709","author":"Ohbayashi","year":"2010","journal-title":"Adv Exp Med Biol"},{"key":"R11-16-20210128","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1111\/j.1398-9995.2006.01207.x","article-title":"Reduced structural proteins in the conjunctival epithelium in allergic eye disease.","volume":"61","author":"Hughes","year":"2006","journal-title":"Allergy"},{"key":"R12-16-20210128","first-page":"77","article-title":"Comparison of effects of alcaftadine and olopatadine on conjunctival epithelium and eosinophil recruitment in a murine model of allergic conjunctivitis.","volume":"5","author":"Ono","year":"2011","journal-title":"Drug Des Devel Ther"},{"key":"R13-16-20210128","doi-asserted-by":"crossref","first-page":"L628","DOI":"10.1152\/ajplung.00046.2006","article-title":"PAR2 activation interrupts E-cadherin adhesion and compromises the airway epithelial barrier: protective effect of betaagonists.","volume":"291","author":"Winter","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"R14-16-20210128","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/jid.2008.13","article-title":"Mite and cockroach allergens activate protease activated receptor 2 and delay epidermal permeability barrier recovery.","volume":"128","author":"Jeong","year":"2008","journal-title":"J Invest Dermatol"},{"key":"R15-16-20210128","first-page":"1304","article-title":"Increased conjunctival expression of protease activated receptor 2 (PAR-2) in seasonal allergic conjunctivitis: a role for abnormal conjunctival epithelial permeability in disease pathogenesis Br J O","volume":"95","author":"Yeoh","year":"2011","journal-title":"phthalmol"},{"key":"R16-16-20210128","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/ICO.0b013e3181f23932","article-title":"Rapid immunochromatographic measurement of specific tear immunoglobulin E in moderate to severe cases of allergic conjunctivitis with Immfast Check J1 in the spring.","volume":"30","author":"Mimura","year":"2011","journal-title":"Cornea"},{"key":"R17-16-20210128","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/01.all.0000183113.63311.11","article-title":"Histamine receptors and the conjunctiva.","volume":"5","author":"Bielory","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R18-16-20210128","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1076\/ceyr.25.3.189.13479","article-title":"Histamine-induced cytokine production and ICAM-1 expression in human conjunctival fibroblasts.","volume":"25","author":"Leonardi","year":"2002","journal-title":"Curr Eye Res"},{"key":"R19-16-20210128","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11882-008-0005-y","article-title":"The new biology of histamine receptors.","volume":"8","author":"Huang","year":"2008","journal-title":"Curr Allergy Asthma Rep"},{"key":"R20-16-20210128","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1111\/j.1398-9995.2011.02612.x","article-title":"Histamine H4 receptors in normal conjunctiva and in vernal keratoconjunctivitis.","volume":"66","author":"Leonardi","year":"2011","journal-title":"Allergy"},{"key":"R21-16-20210128","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s11882-002-0061-7","article-title":"The central role of conjunctival mast cells in the pathogenesis of ocular allergy.","volume":"2","author":"Leonardi","year":"2002","journal-title":"Current Allergy and Asthma Report"},{"key":"R22-16-20210128","first-page":"995","article-title":"The relative contribution of mast cell subsets to conjunctival T(H)2-like cytokines.","volume":"42","author":"Anderson","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R23-16-20210128","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/ni1188","article-title":"Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3.","volume":"6","author":"Kunikata","year":"2005","journal-title":"Nat Immunol"},{"key":"R24-16-20210128","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jaci.2008.09.044","article-title":"Prostaglandin E receptor subtype EP3 in conjunctival epithelium regulates late-phase reaction of experimental allergic conjunctivitis.","volume":"123","author":"Ueta","year":"2009","journal-title":"Allergy Clin Immunol"},{"key":"R25-16-20210128","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/ACI.0b013e32830e6b3a","article-title":"Late-phase reaction in ocular allergy.","volume":"8","author":"Choi","year":"2008","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R26-16-20210128","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s11882-002-0062-6","article-title":"Pathophysiology of ocular allergy: the roles of conjunctival mast cells and epithelial cells.","volume":"2","author":"Stahl","year":"2002","journal-title":"Curr Allergy Asthma Rep"},{"key":"R27-16-20210128","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11882-003-0098-2","article-title":"Epithelial cells in ocular allergy.","volume":"3","author":"Irkec","year":"2003","journal-title":"Curr Allergy Asthma Rep"},{"key":"R28-16-20210128","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.preteyeres.2005.09.002","article-title":"Role of structural cells of the cornea and conjunctiva in the pathogenesis of vernal keratoconjunctivitis.","volume":"25","author":"Kumagai","year":"2006","journal-title":"Prog Retina Eye Res"},{"key":"R29-16-20210128","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1365-2222.2006.02499.x","article-title":"Multiple cytokines in human tear specimens in seasonal and chronic allergic eye disease and in conjunctival fibroblast cultures.","volume":"36","author":"Leonardi","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"R30-16-20210128","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S1350-9462(02)00006-X","article-title":"Vernal keratoconjunctivitis: pathogenesis and treatment.","volume":"21","author":"Leonardi","year":"2002","journal-title":"Prog Ret Eye Res"},{"key":"R31-16-20210128","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00130832-200310000-00011","article-title":"Allergic chronic inflammation of the ocular surface in vernal keratoconjunctivitis.","volume":"3","author":"Bonini","year":"2003","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R32-16-20210128","first-page":"1525","article-title":"Conjunctival mast cell as a mediator of eosinophilic response in ocular allergy.","volume":"14","author":"Miyazaki","year":"2008","journal-title":"Mol Vis"},{"key":"R33-16-20210128","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jaci.2009.06.012","article-title":"Critical role of IgE-dependent mast cell activation in a murine model of allergic conjunctivitis.","volume":"124","author":"Fukuda","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"R34-16-20210128","doi-asserted-by":"crossref","first-page":"48443","DOI":"10.1074\/jbc.M408725200","article-title":"Impact of engagement of FcRI and CC chemokine receptor 1 on mast cell activation and motility.","volume":"279","author":"Toda","year":"2004","journal-title":"J Biol Chem"},{"key":"R35-16-20210128","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.yexmp.2012.02.002","article-title":"Identification of genes and proteins specifically regulated by costimulation of mast cell Fc Receptor I and chemokine receptor 1.","volume":"92","author":"Aye","year":"2012","journal-title":"Exp Mol Pathol"},{"key":"R36-16-20210128","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/intimm\/dxn137","article-title":"Ablation of type I hypersensitivity in experimental allergic conjunctivitis by eotaxin-1CCR3 blockade.","volume":"21","author":"Miyazaki","year":"2009","journal-title":"Int Immunol"},{"key":"R37-16-20210128","first-page":"932","article-title":"Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis.","volume":"17","author":"Wakamatsu","year":"2011","journal-title":"Mol Vis"},{"key":"R39-16-20210128","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1136\/bjo.82.10.1203","article-title":"Allergic eye disease mechanisms.","volume":"82","author":"McGill","year":"1998","journal-title":"Br J Ophthalmol"},{"key":"R40-16-20210128","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2332\/allergolint.O-07-512","article-title":"Depletion of thymus-derived CD4CD25 T cells abrogates the suppressive effects of alphagalactosylceramide treatment on experimental allergic conjunctivitis.","volume":"57","author":"Fukushima","year":"2008","journal-title":"Allergol Int"},{"key":"R41-16-20210128","first-page":"1562","article-title":"Natural killer cells in vernal keratoconjunctivitis.","volume":"13","author":"Lambiase","year":"2007","journal-title":"Molec Vis"},{"key":"R42-16-20210128","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/intimm\/dxq046","article-title":"NKT cells are necessary for maximal expression of allergic conjunctivitis.","volume":"22","author":"Reyes","year":"2010","journal-title":"Int Immunol"},{"key":"R43-16-20210128","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1167\/iovs.10-5959","article-title":"T cells are required for maximal expression of allergic conjunctivitis.","volume":"52","author":"Reyes","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R44-16-20210128","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/0192623311430694","article-title":"Cytokine pathways in allergic disease.","volume":"40","author":"Williams","year":"2012","journal-title":"Toxicol Pathol"},{"key":"R45-16-20210128","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1007\/s00417-006-0285-7","article-title":"Th1- and Th2-type cytokines in chronic ocular allergy.","volume":"244","author":"Leonardi","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"R46-16-20210128","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1398-9995.2008.01858.x","article-title":"Cytokines, matrix metalloproteases, angiogenic and growth factors in tears of normal subjects and vernal keratoconjunctivitis patients.","volume":"64","author":"Leonardi","year":"2009","journal-title":"Allergy"},{"key":"R47-16-20210128","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0161-6420(02)01767-0","article-title":"Tear and mucus eotaxin-1 and eotaxin-2 in allergic keratoconjunctivitis.","volume":"110","author":"Leonardi","year":"2003","journal-title":"Ophthalmology"},{"key":"R48-16-20210128","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s10384-008-0628-5","article-title":"Evaluation of eotaxin-1, -2, and -3 protein production and messenger RNA expression in patients with vernal keratoconjunctivitis.","volume":"53","author":"Shoji","year":"2009","journal-title":"Jpn J Ophthalmol"},{"key":"R49-16-20210128","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1167\/iovs.05-0138","article-title":"Role of interferon-gamma in a mouse model of allergic conjunctivitis.","volume":"46","author":"Stern","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R50-16-20210128","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1167\/iovs.08-3365","article-title":"The role of interleukin-33 in chronic allergic conjunctivitis.","volume":"50","author":"Matsuda","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R51-16-20210128","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00130832-200410000-00020","article-title":"Ocular allergic disease.","volume":"4","author":"Stahl","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R52-16-20210128","first-page":"477","article-title":"Immune mechanisms in allergic eye diseases: what is new Curr Opin Allergy Clin I","volume":"9","author":"Offiah","year":"2009","journal-title":"mmunol"},{"key":"R53-16-20210128","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1167\/iovs.09-4183","article-title":"Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis.","volume":"51","author":"Matsuda","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R54-16-20210128","first-page":"4175","article-title":"Growth factors and collagen distribution in vernal keratoconjunctivitis.","volume":"41","author":"Leonardi","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R55-16-20210128","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1365-2222.2010.03626.x","article-title":"Transforming growth factor-Smad-signalling pathway and conjunctival remodelling in vernal keratoconjunctivitis.","volume":"41","author":"Leonardi","year":"2011","journal-title":"Clin Exp Allergy"},{"key":"R56-16-20210128","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1167\/iovs.02-0766","article-title":"Tear levels and activity of matrix metalloproteinases (MMP)-1 and MMP-9 in vernal keratoconjunctivitis.","volume":"44","author":"Leonardi","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R57-16-20210128","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1042\/CS20100425","article-title":"Toll-like receptors in ocular surface diseases: overview and new findings.","volume":"120","author":"Lambiase","year":"2011","journal-title":"Clin Sci (Lond)"},{"key":"R58-16-20210128","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1136\/bjo.2005.072686","article-title":"Toll-like receptors in ocular immunity and the immunopathogenesis of inflammatory eye disease.","volume":"90","author":"Chang","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"R59-16-20210128","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/156652406776894572","article-title":"Toll-like receptors and corneal innate immunity.","volume":"6","author":"Kumar","year":"2006","journal-title":"Curr Mol Med"},{"key":"R61-16-20210128","first-page":"2037","article-title":"Nerve growth factor modulates toll-like receptor (TLR) 4 and 9 expression in cultured primary VKC conjunctival epithelial cells.","volume":"15","author":"Micera","year":"2009","journal-title":"Mol Vis"},{"key":"R62-16-20210128","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S1081-1206(10)61120-9","article-title":"Toll-like receptor 2 expression on human conjunctival epithelial cells: a pathway for Staphylococcus aureus involvement in chronic ocular proinflammatory responses.","volume":"94","author":"Cook","year":"2005","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R63-16-20210128","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2249.2011.04368.x","article-title":"Toll-like receptor 4 signalling attenuates experimental allergic conjunctivitis.","volume":"164","author":"Chung","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"R64-16-20210128","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1097\/ACI.0b013e32830e6b17","article-title":"The role of neuromediators in ocular allergy.","volume":"8","author":"Micera","year":"2008","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R65-16-20210128","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/00130832-200410000-00015","article-title":"Nerve growth factor and the immune system: old and new concepts in the cross-talk between immune and resident cells during pathophysiological conditions.","volume":"4","author":"Lambiase","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R66-16-20210128","first-page":"47","article-title":"Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitis.","volume":"17","author":"Sacchetti","year":"2011","journal-title":"Mol Vis"},{"key":"R67-16-20210128","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1001\/archopht.124.4.462","article-title":"Altered expression of neurotrasmitter receptors and neuromediators in vernal keratoconjunctivitis.","volume":"124","author":"Motterle","year":"2006","journal-title":"Arch Ophthalmol"}],"container-title":["Current Opinion in Allergy & Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/ACI.0b013e328357a21b","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T16:51:01Z","timestamp":1636563061000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00130832-201210000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/aci.0b013e328357a21b","relation":{},"ISSN":["1528-4050"],"issn-type":[{"value":"1528-4050","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}