{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T23:53:32Z","timestamp":1772236412607,"version":"3.50.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1097\/aco.0000000000000083","type":"journal-article","created":{"date-parts":[[2014,4,4]],"date-time":"2014-04-04T09:43:12Z","timestamp":1396604592000},"page":"353-358","source":"Crossref","is-referenced-by-count":10,"title":["Current management of von Willebrand disease and von Willebrand syndrome"],"prefix":"10.1097","volume":"27","author":[{"given":"Marc E.","family":"Stone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mazzeffi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Derham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Korshin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-16-20210129","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1172\/JCI9604","article-title":"Old concepts and new developments in the study of platelet aggregation.","volume":"105","author":"Ruggeri","year":"2000","journal-title":"J Clin Invest"},{"key":"R2-16-20210129","first-page":"637","article-title":"Binding of human von Willebrand factor to collagen and to collagen-stimulated platelets.","volume":"109","author":"Pietu","year":"1987","journal-title":"J Lab Clin Med"},{"key":"R3-16-20210129","doi-asserted-by":"crossref","first-page":"21948","DOI":"10.1016\/S0021-9258(18)54729-3","article-title":"The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII.","volume":"266","author":"Wise","year":"1991","journal-title":"J Biol Chem"},{"key":"R4-16-20210129","first-page":"224","article-title":"Biosynthesis of human von Willebrand factor.","volume":"18","author":"Verweij","year":"1998","journal-title":"Haemostasis"},{"key":"R5-16-20210129","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1073\/pnas.71.5.1906","article-title":"Synthesis of von Willebrand factor by cultured human endothelial cells.","volume":"71","author":"Jaffe","year":"1974","journal-title":"Proc Natl Acad Sci USA"},{"key":"R6-16-20210129","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1172\/JCI108846","article-title":"Synthesis of factor VIII antigen by cultured guinea pig megakaryocytes.","volume":"60","author":"Nachman","year":"1977","journal-title":"J Clin Invest"},{"key":"R7-16-20210129","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1126\/science.3874428","article-title":"Human von Willebrand factor (vWF): isolation of complimentary DNA (cDNA) clones and chromosomal localization.","volume":"228","author":"Ginsburg","year":"1985","journal-title":"Science"},{"key":"R8-16-20210129","doi-asserted-by":"crossref","first-page":"313","DOI":"10.5505\/tjh.2012.39205","article-title":"The molecular genetics of von Willebrand disease.","volume":"29","author":"Berber","year":"2012","journal-title":"Turk J Haematol"},{"key":"R9-16-20210129","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1182\/blood.V31.6.806.806","article-title":"Acquired von Willebrands syndrome in systemic lupus erythematosus.","volume":"31","author":"Simone","year":"1968","journal-title":"Blood"},{"key":"R10-16-20210129","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/ajh.10298","article-title":"Acquired von Willebrands syndrome: a single institutional experience.","volume":"72","author":"Kumar s, Pruthi","year":"2003","journal-title":"Am J Hematol"},{"key":"R11-16-20210129","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1365-2516.2007.01643.x","article-title":"von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung and Blood Institute (NHLBI) Expert Panel Report (USA).","volume":"14","author":"Nicholas","year":"2008","journal-title":"Haemophilia"},{"key":"R12-16-20210129","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJMoa022831","article-title":"Acquired von Willebrand syndrome in aortic stenosis.","volume":"349","author":"Vincentelli","year":"2003","journal-title":"N Engl J Med"},{"key":"R13-16-20210129","first-page":"196","article-title":"Gastrointestinal bleeding in aortic stenosis.","volume":"2013","author":"Heyde","year":"1958","journal-title":"N Engl J Med"},{"key":"R14-16-20210129","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0887-7963(03)00037-3","article-title":"Gastrointestinal bleeding, angiodysplasia, cardiovascular disease, and acquired von Willebrand syndrome.","volume":"17","author":"Warkentin","year":"2003","journal-title":"Transfus Med Rev"},{"key":"R15-16-20210129","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3109\/14017431.2010.545143","article-title":"No excess surgical blood loss in patients with acquired type 2a von Willebrand disease.","volume":"45","author":"Mikkelsen","year":"2011","journal-title":"Scand Cardiovasc J"},{"key":"R16-16-20210129","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1161\/01.CIR.102.11.1290","article-title":"Proteolysis of von Willebrand factor and shear stress-induced platelet aggregation in patients with aortic valve stenosis.","volume":"102","author":"Pareti","year":"2000","journal-title":"Circulation"},{"key":"R17-16-20210129","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-0037-1613993","article-title":"Acquired von Willebrand syndrome: from pathology to management.","volume":"84","author":"Veyradier","year":"2000","journal-title":"Thromb Haemost"},{"key":"R18-16-20210129","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1182\/blood.V67.3.758.758","article-title":"Loss of the largest von willebrand factor multimers from the plasma of patients with congenital cardiac defects.","volume":"67","author":"Gill","year":"1986","journal-title":"Blood"},{"key":"R19-16-20210129","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ejcts.2007.12.047","article-title":"Nonsurgical bleeding in patients with ventricular assist devices could be explained by acquired von Willebrand disease.","volume":"33","author":"Heilmann","year":"2008","journal-title":"Eur J Cardiothorac Surg"},{"key":"R20-16-20210129","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1160\/TH09-07-0497","article-title":"Acquired von Willebrand syndrome in patients with ventricular assist device or total artificial heart.","volume":"103","author":"Heilmann","year":"2010","journal-title":"Thromb Haemost"},{"key":"R21-16-20210129","doi-asserted-by":"crossref","first-page":"e2013052","DOI":"10.4084\/mjhid.2013.052","article-title":"Changes of von Willebrand factor during pregnancy in women with and without von Willebrand disease.","volume":"5","author":"Castaman","year":"2013","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"R22-16-20210129","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0033-1334867","article-title":"Current diagnostic and therapeutic approaches to patients with acquired von Willebrand syndrome: a 2013 update.","volume":"39","author":"Federici","year":"2013","journal-title":"Semin Thromb Hemost"},{"key":"R24-16-20210129","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1055\/s-0029-1145254","article-title":"Clinical utility of the PFA-100.","volume":"84","author":"Favoloro","year":"2008","journal-title":"Semin Thromb Hemost"},{"key":"R26-16-20210129","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1160\/TH10-12-0782","article-title":"Evaluation of a modified thromboelastography assay for the screening of von Willebrand disease.","volume":"105","author":"Topf","year":"2011","journal-title":"Thromb Haemost"},{"key":"R27-16-20210129","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.jacc.2010.05.016","article-title":"Acquired von Willebrand syndrome after continuous-flow mechanical device support contributes to a high prevalence of bleeding during long-term support and at the time of transplantation.","volume":"56","author":"Uriel","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"R28-16-20210129","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1161\/CIRCHEARTFAILURE.109.877597","article-title":"Acquired von Willebrand syndrome in patients with an axial flow left ventricular assist device.","volume":"3","author":"Meyer","year":"2010","journal-title":"Circ Heart Fail"},{"key":"R29-16-20210129","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.athoracsur.2010.04.099","article-title":"Acquired von Willebrand syndrome in continuous-flow left ventricular assist device recipients.","volume":"90","author":"Crow","year":"2010","journal-title":"Ann Thorac Surg"},{"key":"R30-16-20210129","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.healun.2013.02.006","article-title":"Time course of acquired von Willebrand disease associated with two types of continuous flow left ventricular assist devices: HeartMate II and CircuLite Synergy Pocket Micropump.","volume":"32","author":"Goda","year":"2013","journal-title":"J Heart Lung Transplant"},{"key":"R31-16-20210129","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1111\/j.1538-7836.2006.01847.x","article-title":"A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD).","volume":"4","author":"Tosetto","year":"2005","journal-title":"J Thromb Haemost"},{"key":"R32-16-20210129","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1517\/14712598.2012.667398","article-title":"Biological therapies for von Willebrand disease.","volume":"12","author":"Favoloro","year":"2012","journal-title":"Expert Opin Biol Ther"},{"key":"R34-16-20210129","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1182\/blood-2004-11-4472","article-title":"Use of desmopressin (DDAVP) during early pregnancy in factor VIII-deficient women.","volume":"105","author":"Mannucci","year":"2005","journal-title":"Blood"}],"container-title":["Current Opinion in Anaesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/ACO.0000000000000083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T22:42:19Z","timestamp":1620945739000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00001503-201406000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1097\/aco.0000000000000083","relation":{},"ISSN":["0952-7907"],"issn-type":[{"value":"0952-7907","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}