{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:12:13Z","timestamp":1774714333851,"version":"3.50.1"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1097\/ajp.0000000000000086","type":"journal-article","created":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T09:51:06Z","timestamp":1406886666000},"page":"21-29","source":"Crossref","is-referenced-by-count":16,"title":["Results of a Pilot Multicenter Genotype-based Randomized Placebo-controlled Trial of Propranolol to Reduce Pain After Major Thermal Burn Injury"],"prefix":"10.1097","volume":"31","author":[{"given":"Danielle C.","family":"Orrey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar I.","family":"Halawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey V.","family":"Bortsov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey W.","family":"Shupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel W.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linwood R.","family":"Haith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janelle M.","family":"Hoskins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marion H.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrikant I.","family":"Bangdiwala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandon R.","family":"Roane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy F.","family":"Platts-Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James H.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A.","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel A.","family":"McLean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-4-20210204","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ccell.2003.10.003","article-title":"Burn epidemiology: the patient, the nation, the statistics, and the data resources.","volume":"16","author":"LaBorde","year":"2004","journal-title":"Crit Care Nurs Clin North Am"},{"key":"R2-4-20210204","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2165\/00128071-200001060-00001","article-title":"Treatment of pain in severe burns.","volume":"1","author":"Gallagher","year":"2000","journal-title":"Am J Clin Dermatol"},{"key":"R3-4-20210204","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/00004630-198111000-00004","article-title":"Assessment of pain by burn patients.","volume":"2","author":"Perry","year":"1981","journal-title":"J Burn Care Res"},{"key":"R4-4-20210204","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jpain.2007.02.426","article-title":". Burn injury pain: the continuing challenge.","volume":"8","author":"Summer","year":"2007","journal-title":"J Pain"},{"key":"R5-4-20210204","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1046\/j.1460-9568.2003.02503.x","article-title":". Vagal modulation of nociception is mediated by adrenomedullary epinephrine in the rat.","volume":"17","author":"Khasar","year":"2003","journal-title":"Eur J Neurosci"},{"key":"R6-4-20210204","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1152\/jn.1999.81.3.1104","article-title":"Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors.","volume":"81","author":"Khasar","year":"1999","journal-title":"J Neurophysiol"},{"key":"R7-4-20210204","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.pain.2006.09.022","article-title":". Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both 2- and 3-adrenergic receptors.","volume":"128","author":"Nackley","year":"2007","journal-title":"Pain"},{"key":"R8-4-20210204","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/art.1780230220","article-title":". Propranolol and the treatment of rheumatoid arthritis.","volume":"23","author":"Kaplan","year":"1980","journal-title":"Arthritis Rheum"},{"key":"R9-4-20210204","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.pain.2010.01.023","article-title":". Genetic variation in the beta2-adrenergic receptor but not catecholamine-O-methyltransferase predisposes to chronic pain: results from the 1958 British Birth Cohort Study.","volume":"149","author":"Hocking","year":"2010","journal-title":"Pain"},{"key":"R10-4-20210204","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1002\/ajmg.b.30324","article-title":". Three major haplotypes of the 2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder.","volume":"141B","author":"Diatchenko","year":"2006","journal-title":"Am J Med Genet"},{"key":"R11-4-20210204","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1002\/art.24655","article-title":". Association of adrenergic receptor gene polymorphisms with different fibromyalgia syndrome domains.","volume":"60","author":"Vargas-Alarcon","year":"2009","journal-title":"Arthritis Rheum"},{"key":"R12-4-20210204","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/FPC.0b013e328337f9ab","article-title":". Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study.","volume":"20","author":"Tchivileva","year":"2010","journal-title":"Pharmacogenet Genom"},{"key":"R13-4-20210204","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0031-6997(24)01423-6","article-title":"Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors.","volume":"51","author":"Mannisto","year":"1999","journal-title":"Pharmacol Rev"},{"key":"R14-4-20210204","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/hmg\/ddi013","article-title":". Genetic basis for individual variations in pain perception and the development of a chronic pain condition.","volume":"14","author":"Diatchenko","year":"2005","journal-title":"Hum Mol Genet"},{"key":"R15-4-20210204","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/ana.410130119","article-title":"Observations on the efficacy of propranolol for the prophylaxis of migraine.","volume":"13","author":"Rosen","year":"1983","journal-title":"Ann Neurol"},{"key":"R16-4-20210204","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1526-4610.1982.hed2206268.x","article-title":". Long-term study of propranolol in the treatment of migraine.","volume":"22","author":"Diamond","year":"1982","journal-title":"Headache"},{"key":"R17-4-20210204","first-page":"892","article-title":"Long-term therapy of essential tremor with propranolol.","volume":"115","author":"Murray","year":"1976","journal-title":"Can Med Assoc J"},{"key":"R18-4-20210204","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1212\/WNL.24.1.64","article-title":". Propranolol treatment of essential tremor.","volume":"24","author":"Sweet","year":"1974","journal-title":"Neurology"},{"key":"R19-4-20210204","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1056\/NEJM197405022901802","article-title":"Efficacy of chronic propranolol therapy in action tremors of the familial, senile or essential varieties.","volume":"290","author":"Winkler","year":"1974","journal-title":"N Engl J Med"},{"key":"R20-4-20210204","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/9780470059593.ch16","article-title":"Beta-blockade in burns.","volume":"280","author":"Pereira","year":"2007","journal-title":"Novartis Found Symp"},{"key":"R21-4-20210204","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.yasu.2005.05.005","article-title":"The pharmacologic modulation of the hypermetabolic response to burns.","volume":"39","author":"Pereira","year":"2005","journal-title":"Adv Surg"},{"key":"R22-4-20210204","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0140-6736(04)16360-5","article-title":"Support of the metabolic response to burn injury.","volume":"363","author":"Herndon","year":"2004","journal-title":"Lancet"},{"key":"R23-4-20210204","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/bdd.2510100108","article-title":". Bioavailability of propranolol hydrochloride tablet formulations: application of multiple dose crossover studies.","volume":"10","author":"Eldon","year":"1989","journal-title":"Biopharm Drug Dispos"},{"key":"R25-4-20210204","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1136\/bmj.323.7305.142","article-title":". Relation between insufficient response to antihypertensive treatment and poor compliance with treatment: a prospective case-control study.","volume":"323","author":"Nuesch","year":"2001","journal-title":"BMJ"},{"key":"R26-4-20210204","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1176\/appi.ajp.158.9.1480","article-title":". The peritraumatic distress inventory: a proposed measure of PTSD criterion A2.","volume":"158","author":"Brunet","year":"2001","journal-title":"Am J Psychiatry"},{"key":"R27-4-20210204","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1197\/aemj.10.4.390","article-title":"Validation of a verbally administered numerical rating scale of acute pain for use in the emergency department.","volume":"10","author":"Bijur","year":"2003","journal-title":"Acad Emerg Med"},{"key":"R28-4-20210204","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1023\/A:1007781909213","article-title":"Comparison of the PTSD symptom scale-interview version and the clinician-administered PTSD scale.","volume":"13","author":"Foa","year":"2000","journal-title":"J Trauma Stress"},{"key":"R29-4-20210204","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(01)00349-9","article-title":". Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale.","volume":"94","author":"Farrar","year":"2001","journal-title":"Pain"},{"key":"R30-4-20210204","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0006-3223(01)01279-3","article-title":". Pilot study of secondary prevention of posttraumatic stress disorder with propranolol.","volume":"51","author":"Pitman","year":"2002","journal-title":"Biol Psychiatry"},{"key":"R31-4-20210204","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0006-3223(03)00412-8","article-title":". Immediate treatment with propranolol decreases posttraumatic stress disorder two months after trauma.","volume":"54","author":"Vaiva","year":"2003","journal-title":"Biol Psychiatry"},{"key":"R32-4-20210204","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1023\/A:1020145610914","article-title":"Propranolol for reemergent posttraumatic stress disorder following an event of retraumatization: a case study.","volume":"15","author":"Taylor","year":"2002","journal-title":"J Trauma Stress"},{"key":"R33-4-20210204","first-page":"1244","article-title":"Propranolol treatment for childhood posttraumatic stress disorder, Acute Type A Pilot Study.","volume":"142","author":"Famularo","year":"1988","journal-title":"Arch Pediatr Adolesc Med"},{"key":"R34-4-20210204","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/BCR.0b013e3181921f51","article-title":". The effect of propranolol on posttraumatic stress disorder in burned service members.","volume":"30","author":"McGhee","year":"2009","journal-title":"J Burn Care Res"},{"key":"R35-4-20210204","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/jts.20270","article-title":". Pharmacotherapy to prevent PTSD: results from a randomized controlled proof-of-concept trial in physically injured patients.","volume":"20","author":"Stein","year":"2007","journal-title":"J Trauma Stress"},{"key":"R36-4-20210204","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/jts.2490060405","article-title":". Reliability and validity of a brief instrument for assessing posttraumatic stress disorder.","volume":"6","author":"Foa","year":"1993","journal-title":"J Trauma Stress"},{"key":"R37-4-20210204","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0952-8180(03)00033-3","article-title":". Interleukin balance and early recovery from anesthesia in elderly surgical patients exposed to beta-adrenergic antagonism.","volume":"15","author":"Shyong","year":"2003","journal-title":"J Clin Anesth"},{"key":"R38-4-20210204","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2307\/2531248","article-title":"Longitudinal data analysis for discrete and continuous outcomes.","volume":"42","author":"Zeger","year":"1986","journal-title":"Biometrics"},{"key":"R39-4-20210204","doi-asserted-by":"crossref","first-page":"881","DOI":"10.7326\/0003-4819-142-11-200506070-00005","article-title":". Gulf War veterans health: medical evaluation of a US cohort.","volume":"142","author":"Eisen","year":"2005","journal-title":"Ann Intern Med"},{"key":"R40-4-20210204","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1007\/s11606-007-0233-1","article-title":". Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study.","volume":"22","author":"Parker","year":"2007","journal-title":"J Gen Intern Med"},{"key":"R41-4-20210204","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1111\/j.1528-1157.1995.tb00469.x","article-title":". Dose frequency and dose interval compliance with multiple antiepileptic medications during a controlled clinical trial.","volume":"36","author":"Cramer","year":"1995","journal-title":"Epilepsia"},{"key":"R42-4-20210204","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/pon.1326","article-title":". Factors influencing opioid-taking self-efficacy and analgesic adherence in Taiwanese outpatients with cancer.","volume":"17","author":"Liang","year":"2008","journal-title":"Psychooncology"},{"key":"R43-4-20210204","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1037\/0278-6133.19.2.124","article-title":". Patterns, correlates, and barriers to medication adherence among persons prescribed new treatments for HIV disease.","volume":"19","author":"Catz","year":"2000","journal-title":"Health Psychol"},{"key":"R44-4-20210204","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/00126334-200202011-00002","article-title":"Addressing the challenges of adherence.","volume":"29","author":"Bartlett","year":"2002","journal-title":"J Acquir Immune Defic Syndr"},{"key":"R45-4-20210204","doi-asserted-by":"crossref","first-page":"S554","DOI":"10.1067\/mai.2002.124570","article-title":"Overcoming barriers to nonadherence in asthma treatment.","volume":"109","author":"Bender","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"R47-4-20210204","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.casemgr.2005.01.009","article-title":"Medication adherence: factors influencing compliance with prescribed medication plans.","volume":"16","author":"Vlasnik","year":"2005","journal-title":"Case Manager"},{"key":"R50-4-20210204","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1097\/00005373-198911000-00013","article-title":". The pain of burns: characteristics and correlates.","volume":"29","author":"Choinier","year":"1989","journal-title":"J Trauma Acute Care Surg"},{"key":"R51-4-20210204","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0304-3959(82)90135-X","article-title":". Clinical trial of propranolol in post-traumatic neuralgia.","volume":"14","author":"Scadding","year":"1982","journal-title":"Pain"},{"key":"R53-4-20210204","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/BCR.0b013e31823746ed","article-title":". Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients.","volume":"33","author":"Orrey","year":"2012","journal-title":"J Burn Care Res"}],"container-title":["The Clinical Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/AJP.0000000000000086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T01:32:43Z","timestamp":1746322363000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00002508-201501000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1097\/ajp.0000000000000086","relation":{},"ISSN":["0749-8047"],"issn-type":[{"value":"0749-8047","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]}}}