{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:17:29Z","timestamp":1793780249439,"version":"4.6.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1097\/ajp.0b013e31816778f9","type":"journal-article","created":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T03:07:18Z","timestamp":1218769638000},"page":"585-594","source":"Crossref","is-referenced-by-count":652,"title":["Effect of Microneedle Design on Pain in Human Volunteers"],"prefix":"10.1097","volume":"24","author":[{"given":"Harvinder S.","family":"Gill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald D.","family":"Denson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett A.","family":"Burris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Prausnitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20210204","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.addr.2003.10.023","article-title":"Microneedles for transdermal drug delivery","volume":"56","author":"Prausnitz","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"R2-5-20210204","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1399-543X.2004.00048.x","article-title":"Reducing injection pain in children and adolescents with diabetes: a review of indwelling catheters","volume":"5","author":"Hanas","year":"2004","journal-title":"Pediatr Diabetes"},{"key":"R3-5-20210204","first-page":"169","article-title":"Needle phobia: a neglected diagnosis","volume":"41","author":"Hamilton","year":"1995","journal-title":"J Fam Pract"},{"key":"R4-5-20210204","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.janxdis.2006.01.004","article-title":"Fear of needles and vasovagal reactions among phlebotomy patients","volume":"20","author":"Deacon","year":"2006","journal-title":"J Anxiety Disord"},{"key":"R5-5-20210204","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4269\/ajtmh.2003.68.341","article-title":"Fear of injections in young adults: prevalence and associations","volume":"68","author":"Nir","year":"2003","journal-title":"Am J Trop Med Hyg"},{"key":"R6-5-20210204","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1258\/095646204322637182","article-title":"The global burden of disease attributable to contaminated injections given in health care settings","volume":"15","author":"Hauri","year":"2004","journal-title":"Int J STD AIDS"},{"key":"R7-5-20210204","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrd1304","article-title":"Current status and future potential of transdermal drug delivery","volume":"3","author":"Prausnitz","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"R8-5-20210204","doi-asserted-by":"crossref","first-page":"13755","DOI":"10.1073\/pnas.2331316100","article-title":"Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies","volume":"100","author":"McAllister","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R9-5-20210204","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1365-2133.2004.05921.x","article-title":"Microfabricated silicon microneedles for nonviral cutaneous gene delivery","volume":"150","author":"Chabri","year":"2004","journal-title":"Br J Dermatol"},{"key":"R10-5-20210204","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1007\/s11095-007-9286-4","article-title":"Coating formulations for microneedles","volume":"24","author":"Gill","year":"2007","journal-title":"Pharm Res"},{"key":"R11-5-20210204","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1023\/B:PHAM.0000029282.44140.2e","article-title":"Transdermal delivery of insulin using microneedles in vivo","volume":"21","author":"Martanto","year":"2004","journal-title":"Pharm Res"},{"key":"R12-5-20210204","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nm0402-415","article-title":"Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery","volume":"8","author":"Mikszta","year":"2002","journal-title":"Nat Med"},{"key":"R13-5-20210204","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1128\/CVI.00387-06","article-title":"Preclinical evaluation of microneedle technology for intradermal delivery of influenza vaccines","volume":"14","author":"Alarcon","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"R14-5-20210204","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1213\/00000539-200102000-00041","article-title":"Lack of pain associated with microfabricated microneedles","volume":"92","author":"Kaushik","year":"2001","journal-title":"Anesth Analg"},{"key":"R15-5-20210204","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.jconrel.2006.10.017","article-title":"Coated microneedles for transdermal delivery","volume":"117","author":"Gill","year":"2007","journal-title":"J Control Release"},{"key":"R16-5-20210204","article-title":"Applied Linear Statistical Models","author":"Neter","year":"1996"},{"key":"R17-5-20210204","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/00000542-199504000-00012","article-title":"Analysis of statistical tests to compare visual analog scale measurements among groups","volume":"82","author":"Dexter","year":"1995","journal-title":"Anesthesiology"},{"key":"R19-5-20210204","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1034\/j.1399-5448.2000.010305.x","article-title":"Thinner needles do not influence injection pain, insulin leakage or bleeding in children and adolescents with type 1 diabetes","volume":"1","author":"Hanas","year":"2000","journal-title":"Pediatr Diabetes"},{"key":"R20-5-20210204","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.jaad.2005.08.049","article-title":"Cutaneous innervation: form and function","volume":"53","author":"Oaklander","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"R21-5-20210204","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.jbiomech.2003.12.010","article-title":"Insertion of microneedles into skin: measurement and prediction of insertion force and needle fracture force","volume":"37","author":"Davis","year":"2004","journal-title":"J Biomech"},{"key":"R22-5-20210204","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1090-3801(99)90187-8","article-title":"Pain and mechanical injury of human skin following needle insertions","volume":"3","author":"Egekvist","year":"1999","journal-title":"Eur J Pain"},{"key":"R23-5-20210204","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-0846.1999.tb00137.x","article-title":"Regional variations in pain to controlled mechanical skin traumas from automatic needle insertions and relations to ultrasonography","volume":"5","author":"Egekvist","year":"1999","journal-title":"Skin Res Technol"},{"key":"R24-5-20210204","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S1090-3801(99)90055-1","article-title":"Capillary blood sampling: relation between lancet diameter, lancing pain and blood volume","volume":"3","author":"Fruhstorfer","year":"1999","journal-title":"Eur J Pain"},{"key":"R25-5-20210204","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/08990220600700925","article-title":"Pain following controlled cutaneous insertion of needles with different diameters","volume":"23","author":"Arendt-Nielsen","year":"2006","journal-title":"Somatosens Mot Res"},{"key":"R26-5-20210204","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/pdi.1960120414","article-title":"Capillary blood sampling: how much pain is necessary? Part 2: Relation between penetration depth and puncture pain","volume":"12","author":"Fruhstorfer","year":"1995","journal-title":"Pract Diabetes Int"},{"key":"R27-5-20210204","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2005.02.002","article-title":"Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery","volume":"104","author":"Park","year":"2005","journal-title":"J Control Release"},{"key":"R28-5-20210204","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1043454206296023","article-title":"Needle phobia and stress-reducing medical devices in pediatric and adult chemotherapy patients","volume":"24","author":"Kettwich","year":"2007","journal-title":"J Pediatr Oncol Nurs"}],"container-title":["The Clinical Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00002508-200809000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:06:10Z","timestamp":1786035970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002508-200809000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/ajp.0b013e31816778f9","relation":{},"ISSN":["0749-8047"],"issn-type":[{"value":"0749-8047","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}