{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:59:36Z","timestamp":1793458776979,"version":"4.5.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1097\/ajp.0b013e31829e9d2a","type":"journal-article","created":{"date-parts":[[2013,7,25]],"date-time":"2013-07-25T13:02:47Z","timestamp":1374757367000},"page":"409-420","source":"Crossref","is-referenced-by-count":62,"title":["Chronic Widespread Pain"],"prefix":"10.1097","volume":"30","author":[{"given":"Bj\u00f6rn","family":"Gerdle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida","family":"Forsberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazdar","family":"Ghafouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linn","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niclas","family":"Stensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijar","family":"Ghafouri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20210204","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.berh.2010.01.010","article-title":"Peripheral pain mechanisms in chronic widespread pain.","volume":"25","author":"Staud","year":"2011","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"R2-5-20210204","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2340\/16501977-0052","article-title":"Generalized pain is associated with more negative consequences than local or regional pain: a study of chronic whiplash-associated disorders.","volume":"39","author":"Peolsson","year":"2007","journal-title":"J Rehabil Med"},{"key":"R5-5-20210204","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/jnr.22512","article-title":"Central amplification and fibromyalgia: disorder of pain processing.","volume":"89","author":"Petersel","year":"2011","journal-title":"J Neurosci Res"},{"key":"R6-5-20210204","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.amjmed.2009.09.008","article-title":"Pathophysiology of fibromyalgia.","volume":"122","author":"Bradley","year":"2009","journal-title":"Am J Med"},{"key":"R7-5-20210204","doi-asserted-by":"crossref","first-page":"E217","DOI":"10.36076\/ppj.2011\/14\/E217","article-title":"Fibromyalgia: an afferent processing disorder leading to a complex pain generalized syndrome.","volume":"14","author":"Smith","year":"2011","journal-title":"Pain Physician"},{"key":"R8-5-20210204","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4065\/74.4.385","article-title":"Emerging concepts in the neurobiology of chronic pain: evidence of abnormal sensory processing in fibromyalgia.","volume":"74","author":"Bennett","year":"1999","journal-title":"Mayo Clin Proc"},{"key":"R9-5-20210204","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/10582450801960339","article-title":"The role of peripheral input for chronic pain syndromes like fibromyalgia syndrome.","volume":"16","author":"Staud","year":"2008","journal-title":"J Musculoskelet Pain"},{"key":"R16-5-20210204","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0304-3959(95)00112-3","article-title":"Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls.","volume":"64","author":"Kosek","year":"1996","journal-title":"Pain"},{"key":"R18-5-20210204","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1017\/S0029665199001238","article-title":"Vasoactive substances in the interstitium of contracting skeletal muscle examined by microdialysis.","volume":"58","author":"Bangsbo","year":"1999","journal-title":"Proc Nutr Soc"},{"key":"R29-5-20210204","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0197-2456(90)90005-M","article-title":"Power and sample size calculations: a review and computer program.","volume":"11","author":"Dupont","year":"1990","journal-title":"Control Clin Trials"},{"key":"R31-5-20210204","doi-asserted-by":"crossref","first-page":"562","DOI":"10.2340\/16501977-0207","article-title":"Catastrophizing, depression, and pain: correlation with and influence on quality of life and healtha study of chronic whiplash-associated disorders.","volume":"40","author":"Borsbo","year":"2008","journal-title":"J Rehabil Med"},{"key":"R32-5-20210204","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1080\/09638280903110079","article-title":"The complex interplay between pain intensity, depression, anxiety and catastrophising with respect to quality of life and disability.","volume":"31","author":"Borsbo","year":"2009","journal-title":"Disabil Rehabil"},{"key":"R36-5-20210204","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0165-0270(91)90114-F","article-title":"The internal reference technique in microdialysis: a practical approach to monitoring dialysis efficiency and to calculating tissue concentration from dialysate samples.","volume":"40","author":"Scheller","year":"1991","journal-title":"J Neurosci Methods"},{"key":"R39-5-20210204","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.pain.2011.01.032","article-title":"Elevated muscle interstitial levels of pain-inducing substances in symptomatic muscles in patients with polymyalgia rheumatica.","volume":"152","author":"Kreiner","year":"2011","journal-title":"Pain"},{"key":"R44-5-20210204","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neulet.2012.03.042","article-title":"Imaging central neurochemical alterations in chronic pain with proton magnetic resonance spectroscopy.","volume":"520","author":"Harris","year":"2012","journal-title":"Neurosci Lett"},{"key":"R46-5-20210204","doi-asserted-by":"crossref","first-page":"867S","DOI":"10.3945\/ajcn.2009.27462BB","article-title":"The blood-brain barrier and glutamate.","volume":"90","author":"Hawkins","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"R50-5-20210204","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1152\/jn.2001.85.6.2446","article-title":"Characteristics of glutamate-evoked temporomandibular joint afferent activity in the rat.","volume":"85","author":"Cairns","year":"2001","journal-title":"J Neurophysiol"},{"key":"R51-5-20210204","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1471-4892(01)00002-9","article-title":"Peripheral excitatory amino acids.","volume":"1","author":"Carlton","year":"2001","journal-title":"Curr Opin Pharmacol"},{"key":"R56-5-20210204","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/ar3305","article-title":"Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines.","volume":"13","author":"Schaible","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"R57-5-20210204","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/(SICI)1096-9861(19980202)391:1<78::AID-CNE7>3.0.CO;2-O","article-title":"Ultrastructural analysis of NMDA, AMPA, and kainate receptors on unmyelinated and myelinated axons in the periphery.","volume":"391","author":"Coggeshall","year":"1998","journal-title":"J Comp Neurol"},{"key":"R60-5-20210204","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/WNL.0b013e318233b3e4","article-title":"Nitric oxide: a pleiotropic signal in the nervous system.","volume":"77","author":"Benarroch","year":"2011","journal-title":"Neurology"},{"key":"R63-5-20210204","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/10582450801960388","article-title":"The role of peripheral glutamate and glutamate receptors in muscle pain.","volume":"16","author":"Cairns","year":"2008","journal-title":"J Musculoskelet Pain"},{"key":"R71-5-20210204","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1164\/arrd.1984.129.2P2.S35","article-title":"The anaerobic threshold measurement to evaluate exercise performance.","volume":"129","author":"Wasserman","year":"1984","journal-title":"Am Rev Respir Dis"},{"key":"R73-5-20210204","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3109\/03009748609102084","article-title":"Muscle tissue oxygen pressure in primary fibromyalgia.","volume":"15","author":"Lund","year":"1986","journal-title":"Scand J Rheumatol"},{"key":"R74-5-20210204","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S1090-3801(03)00090-9","article-title":"Peripheral effects of needle stimulation (acupuncture) on skin and muscle blood flow in fibromyalgia.","volume":"8","author":"Sandberg","year":"2004","journal-title":"Eur J Pain"},{"key":"R75-5-20210204","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1242\/jeb.01961","article-title":"Lactatea signal coordnating cell and systemic function.","volume":"208","author":"Philip","year":"2005","journal-title":"Exp Biol"},{"key":"R76-5-20210204","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1242\/dmm.007724","article-title":"Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments.","volume":"4","author":"Draoui","year":"2011","journal-title":"Dis Model Mech"},{"key":"R77-5-20210204","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1113\/jphysiol.2009.178350","article-title":"Cell-cell and intracellular lactate shuttles.","volume":"587","author":"Brooks","year":"2009","journal-title":"J Physiol"},{"key":"R78-5-20210204","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1113\/jphysiol.2003.058701","article-title":"Lactate metabolism: a new paradigm for the third millenium.","volume":"558","author":"Gladden","year":"2004","journal-title":"J Physiol (Lond)"},{"key":"R79-5-20210204","doi-asserted-by":"crossref","first-page":"R502","DOI":"10.1152\/ajpregu.00114.2004","article-title":"Biochemistry of exercise-induced metabolic acidosis.","volume":"287","author":"Robergs","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R81-5-20210204","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1097\/PCC.0b013e3182211aed","article-title":"Lactate and acid base as a hemodynamic monitor and markers of cellular perfusion.","volume":"12","author":"Allen","year":"2011","journal-title":"Pediatr Crit Care Med"},{"key":"R82-5-20210204","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1748-1716.2010.02122.x","article-title":"Lactate kinetics in human tissues at rest and during exercise.","volume":"199","author":"van Hall","year":"2010","journal-title":"Acta Physiol (Oxf)"},{"key":"R89-5-20210204","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1469-7793.2001.t01-1-00161.x","article-title":"Protective effects of lactic acid on force production in rat skeletal muscle.","volume":"536","author":"Nielsen","year":"2001","journal-title":"J Physiol"},{"key":"R90-5-20210204","doi-asserted-by":"crossref","first-page":"467S","DOI":"10.3945\/ajcn.2008.26717D","article-title":"Muscle mitochondrial changes with aging and exercise.","volume":"89","author":"Lanza","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"R92-5-20210204","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/rheumatology\/41.7.721","article-title":"Editorial. The muscle in fibromyalgia.","volume":"41","author":"Bengtsson","year":"2002","journal-title":"Rheumatol"},{"key":"R93-5-20210204","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/03009748609092661","article-title":"Muscle biopsy in primary fibromyalgia. Light-microscopical and histochemical findings.","volume":"15","author":"Bengtsson","year":"1986","journal-title":"Scand J Rheumatol"},{"key":"R94-5-20210204","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrrheum.2011.98","article-title":"Fibromyalgia: from pathophysiology to therapy.","volume":"7","author":"Schmidt-Wilcke","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"R95-5-20210204","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1136\/jnnp.57.9.1106","article-title":"Muscle strength, voluntary activation, twitch properties, and endurance in patients with fibromyalgia.","volume":"57","author":"Norregaard","year":"1994","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R97-5-20210204","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1100\/tsw.2001.254","article-title":"ASIC3: a lactic acid sensor for cardiac pain.","volume":"1","author":"Immke","year":"2001","journal-title":"ScientificWorldJournal"},{"key":"R100-5-20210204","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1016-8478(23)25242-5","article-title":"Painful channels in sensory neurons.","volume":"20","author":"Lee","year":"2005","journal-title":"Mol Cells"},{"key":"R101-5-20210204","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00424-010-0917-y","article-title":"Ion channels in inflammation.","volume":"461","author":"Eisenhut","year":"2011","journal-title":"Pflugers Arch"},{"key":"R103-5-20210204","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00424-009-0724-5","article-title":"Mitochondrial function as a determinant of life span.","volume":"459","author":"Lanza","year":"2010","journal-title":"Pflugers Arch"},{"key":"R104-5-20210204","doi-asserted-by":"crossref","first-page":"982794","DOI":"10.1155\/2012\/982794","article-title":"Reactive oxygen species in skeletal muscle signaling.","volume":"2012","author":"Barbieri","year":"2012","journal-title":"J Signal Transduct"},{"key":"R107-5-20210204","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bcp.2010.03.007","article-title":"The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds.","volume":"80","author":"Kao","year":"2010","journal-title":"Biochem Pharmacol"},{"key":"R108-5-20210204","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1365-2796.2007.01789.x","article-title":"Ethyl pyruvate: a novel anti-inflammatory agent.","volume":"261","author":"Fink","year":"2007","journal-title":"J Intern Med"}],"container-title":["The Clinical Journal of Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/AJP.0b013e31829e9d2a","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T06:05:32Z","timestamp":1715753132000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00002508-201405000-00005"}},"subtitle":["Increased Glutamate and Lactate Concentrations in the Trapezius Muscle and Plasma"],"short-title":[],"issued":{"date-parts":[[2014,5]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1097\/ajp.0b013e31829e9d2a","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718047723.793482834","asserted-by":"object"}]},"ISSN":["0749-8047"],"issn-type":[{"value":"0749-8047","type":"print"}],"subject":[],"published":{"date-parts":[[2014,5]]}}}