{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T17:16:43Z","timestamp":1773681403083,"version":"3.50.1"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Propofol (2,6-diisopropylphenol) is an anesthetic drug with antioxidant and antiinflammatory properties, documented both in vitro and in experimental models of ischemia-reperfusion injury and septic shock. These properties have been related to the similarity of its chemical structure to that of endogenous tocopherols, which are phenol-containing radical scavengers. This study evaluated the effects of propofol on alpha- and gamma-tocopherol (alpha- and gamma-T) levels and on selected markers of oxidant-antioxidant and inflammatory status in patients undergoing cardiac surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were randomly assigned for anesthesia with either propofol (propofol group, n = 22) or sevoflurane (control group, n = 21). Plasma levels of alpha- and gamma-T, individual antioxidant capacity, malondialdehyde, and interleukin 10 were measured before, during, and after anesthesia. In addition, levels of the proinflammatory prostaglandin E2 as a marker of cyclooxygenase-2 activity and those of interleukin 10 were measured in whole blood cultured with bacterial lipopolysaccharide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gamma-T levels increased significantly during surgery in propofol group (P &lt; 0.0001 vs. control group). By contrast, alpha-T similarly decreased in both groups. Malondialdehyde and interleukin 10 increased markedly and individual antioxidant capacity decreased, without differences between groups. Prostaglandin E2 levels measured 24 h after anesthesia induction were significantly lower in the propofol than in the control group. In vitro studies highlighted the different capacity of gamma- and alpha-T to impair prostaglandin E2 synthesis by human monocytes challenged with bacterial lipopolysaccharide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The antiinflammatory properties of propofol that may be linked to its effect on gamma-T levels could be relevant in controlling the inflammatory response that accompanies tissue injury during reperfusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/aln.0b013e318173efb4","type":"journal-article","created":{"date-parts":[[2008,5,19]],"date-time":"2008-05-19T03:04:42Z","timestamp":1211166282000},"page":"988-997","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Anesthetic Propofol Enhances Plasma \u03b3-Tocopherol Levels in Patients Undergoing Cardiac Surgery"],"prefix":"10.1097","volume":"108","author":[{"given":"Viviana","family":"Cavalca","sequence":"first","affiliation":[{"name":"Assistant Professor, Institute of Cardiology."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Colli","sequence":"additional","affiliation":[{"name":"Associate Professor."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Veglia","sequence":"additional","affiliation":[{"name":"Temporary Professor, Unit of Biostatistics."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Eligini","sequence":"additional","affiliation":[{"name":"Assistant Professor."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Zingaro","sequence":"additional","affiliation":[{"name":"Research Fellow, Laboratory of Cellular Biology and Biochemistry of Atherothrombosis."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Squellerio","sequence":"additional","affiliation":[{"name":"Research Fellow, Laboratory of Cellular Biology and Biochemistry of Atherothrombosis."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Rondello","sequence":"additional","affiliation":[{"name":"Resident in Anesthesiology and Intensive Care Unit."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliana","family":"Cighetti","sequence":"additional","affiliation":[{"name":"Full Professor, Department of Preclinic Sciences, Laboratorio Interdisciplinare di Tecnologie Avanzate, Vialba, University of Milan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Tremoli","sequence":"additional","affiliation":[{"name":"Full Professor, Department of Pharmacological Sciences, University of Milan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erminio","family":"Sisillo","sequence":"additional","affiliation":[{"name":"Chief of Anesthesiology and Intensive Care Unit, Centro Cardiologico Monzino, Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.), University of Milan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-6-20251013"},{"key":"R2-6-20251013"},{"key":"R3-6-20251013"},{"key":"R4-6-20251013"},{"key":"R5-6-20251013"},{"key":"R6-6-20251013"},{"key":"R7-6-20251013"},{"key":"R8-6-20251013"},{"key":"R9-6-20251013"},{"key":"R10-6-20251013"},{"key":"R11-6-20251013"},{"key":"R12-6-20251013"},{"key":"R13-6-20251013"},{"key":"R14-6-20251013"},{"key":"R15-6-20251013"},{"key":"R16-6-20251013"},{"key":"R17-6-20251013"},{"key":"R18-6-20251013"},{"key":"R19-6-20251013"},{"key":"R20-6-20251013"},{"key":"R21-6-20251013"},{"key":"R22-6-20251013"},{"key":"R23-6-20251013"},{"key":"R24-6-20251013"},{"key":"R25-6-20251013"},{"key":"R26-6-20251013"},{"key":"R27-6-20251013"},{"key":"R28-6-20251013"},{"key":"R29-6-20251013"},{"key":"R30-6-20251013"},{"key":"R31-6-20251013"},{"key":"R32-6-20251013"},{"key":"R33-6-20251013"},{"key":"R34-6-20251013"},{"key":"R35-6-20251013"},{"key":"R36-6-20251013"},{"key":"R37-6-20251013"},{"key":"R38-6-20251013"},{"key":"R39-6-20251013"},{"key":"R40-6-20251013"},{"key":"R41-6-20251013"},{"key":"R42-6-20251013"},{"key":"R43-6-20251013"},{"key":"R44-6-20251013"},{"key":"R45-6-20251013"},{"key":"R46-6-20251013"},{"key":"R47-6-20251013"},{"key":"R48-6-20251013"},{"key":"R49-6-20251013"},{"key":"R50-6-20251013"},{"key":"R51-6-20251013"},{"key":"R52-6-20251013"},{"key":"R53-6-20251013"},{"key":"R54-6-20251013"},{"key":"R55-6-20251013"},{"key":"R56-6-20251013"},{"key":"R57-6-20251013"}],"container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/108\/6\/988\/367627\/0000542-200806000-00006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-200806000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T16:01:18Z","timestamp":1760371278000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-200806000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,1]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e318173efb4","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1120729.576966","asserted-by":"object"}]},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2008,6,1]]}}}