{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:49:34Z","timestamp":1790257774415,"version":"4.1.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2008,6,1]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Acid aspiration is a complication of general anesthesia. Most animal models developed to define its pathophysiology have focused on the acute (&lt; or =24 h) phase of the injury. The authors describe a model of acid aspiration allowing the study of this type of lung injury over time.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The authors instilled hydrochloric acid (0.1 m, 1.5 ml\/kg) or normal saline in the right bronchus of mice. Lung injury was evaluated at 6 h, 12 h, 24 h, and 2 weeks by assessing arterial blood gases, respiratory system compliance, lung wet weight normalized by body weight, lung myeloperoxidase activity, and histology. Twelve hours and 2 weeks after injury, a computed tomography scan was obtained.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In the hydrochloric acid group, arterial oxygen tension decreased (P &lt; 0.05) at 12 and 24 h, whereas it recovered at 2 weeks; respiratory system compliance was lower both at 24 h and 2 weeks (P &lt; 0.05). Lung weight increased at 12 and 24 h (P &lt; 0.05). Myeloperoxidase activity peaked between 6 and 12 h. Computed tomography at 12 h showed that almost 30% of the injured lung was abnormally aerated. Although reduced, the abnormalities were still present at 2 weeks as confirmed by a fibrotic scar well evident at histologic examination.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The authors characterized a murine model of regional acid aspiration allowing long-term survival. Despite a partial recovery, at 2 weeks the injury persisted, with evidence of fibrosis and lung compliance reduction. This long-term, low-mortality model seems suitable for assessment of the effects of different therapies on lung injury and repair.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/aln.0b013e318173f64f","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T12:59:34Z","timestamp":1236257974000},"page":"1037-1046","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":61,"title":["Lung Injury and Recovery in a Murine Model of Unilateral Acid Aspiration"],"prefix":"10.1097","volume":"108","author":[{"given":"Maria","family":"Amigoni","sequence":"first","affiliation":[{"name":"Resident."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Bellani","sequence":"additional","affiliation":[{"name":"Research Fellow."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Scanziani","sequence":"additional","affiliation":[{"name":"Resident."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Masson","sequence":"additional","affiliation":[{"name":"Research Scientist, Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bertoli","sequence":"additional","affiliation":[{"name":"Resident."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Radaelli","sequence":"additional","affiliation":[{"name":"Research fellow, Department of Veterinary Pathology, Hygiene and Public Health, Section of Veterinary and Avian Pathology, Faculty of Veterinary Medicine, University of Milan, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00f2","family":"Patroniti","sequence":"additional","affiliation":[{"name":"Research Fellow."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Di Lelio","sequence":"additional","affiliation":[{"name":"Chairman, Department of Radiology, San Gerardo Hospital, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pesenti","sequence":"additional","affiliation":[{"name":"Professor of Anesthesia, Department of Experimental Medicine, University of Milano-Bicocca and Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Monza, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Latini","sequence":"additional","affiliation":[{"name":"Research Scientist, Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, 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