{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:57:04Z","timestamp":1791143824565,"version":"4.1.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"\n Background<\/jats:title>\n Meperidine proved to be more effective in treatment of shivering than equianalgesic doses of other opioids, especially pure mu-agonists. Further, meperidine has well known nonopioid actions including agonistic effects at alpha2-adrenoceptors in vitro. Accordingly, the authors investigated nonopioid receptor-mediated effects of meperidine on thermoregulation using a mice model of nonshivering thermogenesis. To differentiate conceivable alpha2-adrenoceptor subtype specific interactions the authors analyzed wild-type mice and knock-out mice with deletion of the alpha2A-, alpha2B-, or alpha2C-adrenoceptor.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Ten mice per group (n = 60) were injected with saline, meperidine (20 mg\/kg), saline plus naloxone (125 microg\/kg), meperidine plus naloxone, fentanyl (50 microg\/kg) plus naloxone, or meperidine plus atipamezole (2 mg\/kg) intraperitoneally. Each mouse was subjected to the six different treatments. Then they were positioned into a plexiglas chamber where rectal temperature and mixed expired carbon dioxide were measured while whole body cooling was performed. Maximum response intensity and thermoregulatory threshold temperature of nonshivering thermogenesis were analyzed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Meperidine decreased the thermoregulatory threshold temperature in wild-type mice and alpha2B- and alpha2C-adrenoceptor knock-out mice. This effect ended after injection of the alpha2-adrenoceptor antagonist atipamezole. In wild-type and alpha2B-adrenoceptor knock-out mice, the decrease of thermoregulatory threshold was not reversible by administration of the opioid receptor antagonist naloxone. In contrast, in alpha2A-adrenoceptor knock-out mice, no decline of thermoregulatory threshold following meperidine injection was detectable. Maximum response intensity of nonshivering thermogenesis was comparable in all groups.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The authors' results suggest a major role of alpha2-adrenoceptors, especially the alpha2A subtype, in the mediation of thermoregulatory effects caused by meperidine in mice.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/aln.0b013e31817c02fc","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T13:10:34Z","timestamp":1236258634000},"page":"95-100","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Differential Effects of \u03b12-adrenoceptors in the Modulation of the Thermoregulatory Response in Mice Induced by Meperidine"],"prefix":"10.1097","volume":"109","author":[{"given":"Jan","family":"H\u00f6cker","sequence":"first","affiliation":[{"name":"Staff Anesthesiologist."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Paris","sequence":"additional","affiliation":[{"name":"Staff Anesthesiologist."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Scholz","sequence":"additional","affiliation":[{"name":"Professor and Chair, Department of Anaesthesiology and Intensive Care Medicine, University Hospital Schleswig-Holstein, Campus Kiel, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter\u00a0H.","family":"Tonner","sequence":"additional","affiliation":[{"name":"Professor and Chair, Department of Anaesthesiology and Intensive Care Medicine, Hospital \u201cLinks der Weser,\u201d Bremen, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Staff Anesthesiologist."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Bein","sequence":"additional","affiliation":[{"name":"Associate Professor."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20251013"},{"key":"R2-16-20251013"},{"key":"R3-16-20251013"},{"key":"R4-16-20251013"},{"key":"R5-16-20251013"},{"key":"R6-16-20251013"},{"key":"R7-16-20251013"},{"key":"R8-16-20251013"},{"key":"R9-16-20251013"},{"key":"R10-16-20251013"},{"key":"R11-16-20251013"},{"key":"R12-16-20251013"},{"key":"R13-16-20251013"},{"key":"R14-16-20251013"},{"key":"R15-16-20251013"},{"key":"R16-16-20251013"},{"key":"R17-16-20251013"},{"key":"R18-16-20251013"},{"key":"R19-16-20251013"},{"key":"R20-16-20251013"},{"key":"R21-16-20251013"},{"key":"R22-16-20251013"}],"container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/109\/1\/95\/655747\/0000542-200807000-00016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-200807000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T16:01:12Z","timestamp":1760371272000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-200807000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e31817c02fc","relation":{},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7,1]]}}}