{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:37:19Z","timestamp":1787009839453,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nerve blocks provide analgesia after surgery. The authors tested whether nerve blocks have antiinflammatory effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients had combined sciatic (single-shot) and continuous femoral block (48 h) (block group) or morphine patient-controlled analgesia after total knee arthroplasty. Pain at rest and upon movement was monitored at 1 (D1), 4 (D4), and 7 days (D7) and 1 (M1) and 3 months (M3) after surgery. Knee inflammation was evaluated (skin temperature, knee circumference) before surgery and at D1, D4, D7, M1, and M3. Plasma cytokine concentrations (interleukin [IL]-6, IL-1beta, tumor necrosis factor [TNF], IL-10, soluble receptor 1 of TNF [sTNF-R1]) were measured before surgery and at 4 h, D1, D4, and D7 after surgery. Capsule and synovial membrane cytokines were measured (IL-6, TNF, IL-1, IL-10). Knee flexion was evaluated before surgery and at D1, D4, D7, M1, and M3. Morphine use and recovery time to autonomy were monitored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pain at rest and upon movement was lower in the block group than in patient-controlled analgesia patients between D1 and D7 (analysis of variance, P &lt; 0.005). Knee flexion was improved in the block group for D1 to M1 (analysis of variance, P &lt; 0.0001). Block group patients recovered nonassisted mobilization (t test, P = 0.04) and toilet use (t test, P = 0.03) more rapidly. Knee circumference and skin temperature were lower in the block group between D1 and D7 (analysis of variance, P &lt; 0.05). Synovial membrane IL-1 (P &lt; 0.05) and IL-10 (P &lt; 0.01) increased, and plasma IL-6 and sTNF-R1 peaked at 24 h, with no difference between groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Nerve blocks inhibited clinical inflammation after total knee arthroplasty, with no change in tissue and plasma cytokine concentrations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/aln.0b013e318182c2a1","type":"journal-article","created":{"date-parts":[[2008,8,15]],"date-time":"2008-08-15T03:11:16Z","timestamp":1218769876000},"page":"484-490","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":93,"title":["Antiinflammatory Effect of Peripheral Nerve Blocks after Knee Surgery"],"prefix":"10.1097","volume":"109","author":[{"given":"Fr\u00e9d\u00e9ric","family":"Martin","sequence":"first","affiliation":[{"name":"Anaesthesia Fellow."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9ria","family":"Martinez","sequence":"additional","affiliation":[{"name":"Staff Anesthesiologist."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u00a0Xavier","family":"Mazoit","sequence":"additional","affiliation":[{"name":"Staff Anesthesiologist, Universit\u00e9 Paris-Sud, laboratoire d\u2019anesth\u00e9sie, UPRES EA3540 Facult\u00e9 de M\u00e9decine, Le Kremlin-Bic\u00eatre, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Bouhassira","sequence":"additional","affiliation":[{"name":"Neurologist, Director of Research, INSERM, U-792, H\u00f4pital Ambroise Par\u00e9, Centre d\u2019Evaluation et de Traitement de la Douleur, France; Universit\u00e9 Versailles Saint-Quentin, Versailles, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Cherif","sequence":"additional","affiliation":[{"name":"Anaesthesia Resident."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc\u00a0Edouard","family":"Gentili","sequence":"additional","affiliation":[{"name":"Staff Anesthesiologist, service d\u2019anesth\u00e9sie, Centre Hospitalier St Gr\u00e9goire, St Gr\u00e9goire, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Piriou","sequence":"additional","affiliation":[{"name":"Professor of Orthopedic Surgery, H\u00f4pital Raymond Poincar\u00e9."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Chauvin","sequence":"additional","affiliation":[{"name":"Professor of Anaesthesia, Service d\u2019anesth\u00e9sie, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Raymond Poincar\u00e9."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Professor of Anaesthesia, Service d\u2019anesth\u00e9sie, Assistance Publique H\u00f4pitaux de Paris, H\u00f4pital Raymond Poincar\u00e9."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20251013"},{"key":"R2-19-20251013"},{"key":"R3-19-20251013"},{"key":"R4-19-20251013"},{"key":"R5-19-20251013"},{"key":"R6-19-20251013"},{"key":"R7-19-20251013"},{"key":"R8-19-20251013"},{"key":"R9-19-20251013"},{"key":"R10-19-20251013"},{"key":"R11-19-20251013"},{"key":"R12-19-20251013"},{"key":"R13-19-20251013"},{"key":"R14-19-20251013"},{"key":"R15-19-20251013"},{"key":"R16-19-20251013"},{"key":"R17-19-20251013"},{"key":"R18-19-20251013"},{"key":"R19-19-20251013"},{"key":"R20-19-20251013"},{"key":"R21-19-20251013"},{"key":"R22-19-20251013"},{"key":"R23-19-20251013"},{"key":"R24-19-20251013"},{"key":"R25-19-20251013"},{"key":"R26-19-20251013"},{"key":"R27-19-20251013"},{"key":"R28-19-20251013"},{"key":"R29-19-20251013"},{"key":"R30-19-20251013"},{"key":"R31-19-20251013"},{"key":"R32-19-20251013"},{"key":"R33-19-20251013"},{"key":"R34-19-20251013"},{"key":"R35-19-20251013"},{"key":"R36-19-20251013"},{"key":"R37-19-20251013"},{"key":"R38-19-20251013"},{"key":"R39-19-20251013"},{"key":"R40-19-20251013"}],"container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/109\/3\/484\/656165\/0000542-200809000-00019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-200809000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T16:00:41Z","timestamp":1760371241000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-200809000-00018"}},"subtitle":["Clinical and Biologic Evaluation"],"short-title":[],"issued":{"date-parts":[[2008,9,1]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e318182c2a1","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1119281.576570","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1119281.577104","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1119281.576511","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1119281.576850","asserted-by":"object"}]},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9,1]]}}}