{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:01:50Z","timestamp":1789434110966,"version":"build-2803163510"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2010,1,1]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>N-Methyl-D-aspartate receptor antagonists reverse hyperalgesia during morphine infusion in male mice only. Because the melanocortin-1 receptor can act as a female-specific counterpart to N-methyl-D-aspartate receptors in kappa-opioid analgesic mechanisms, the authors assessed the contribution of melanocortin-1 receptors to the sex-specific mechanisms underlying morphine hyperalgesia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The tail-withdrawal test was used to compare the nociceptive responses of male and female C57BL\/6J (B6) mice with those of C57BL\/6J-Mc(1r(e\/e)) mice, spontaneous mutants of the B6 background lacking functional melanocortin-1 receptors, during continuous morphine infusion (1.6 and 40.0 mgkg(-1) . 24 h(-1)). Separate groups of hyperalgesic B6 and outbred CD-1 mice were injected with MK-801 or MSG606, selective N-methyl-D-aspartate and melanocortin-1 receptor antagonists, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Morphine infusion (40.0 mg . kg(-1) . 24 h(-1)) reduced baseline withdrawal latencies by 45-55% in B6 mice of both sexes, indicating hyperalgesia; this increased nociception was manifest in male e\/e mice only. Although MK-801 reversed hyperalgesia in male mice only, increasing latencies by 72%, MSG606 increased latencies by approximately 60% exclusively in females. A lower morphine infusion dose (1.6 mg . kg(-1) . 24 h(-1)) reduced baseline withdrawal latencies by 45-52% in B6 and e\/e mice of both sexes, which was reversed by MK-801, but not MSG606, in both male and female B6 mice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The data indicate the sex-specific mediation of high-dose morphine-induced hyperalgesia by N-methyl-d-aspartate and melanocortin-1 receptors in male and female mice, respectively, suggesting a broader relevance of this known sexual dimorphism. The data further indicate that the neural substrates contributing to hyperalgesia are morphine dose-dependent.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/aln.0b013e3181c53849","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T10:35:02Z","timestamp":1261046102000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":60,"title":["Sex-specific Mediation of Opioid-induced Hyperalgesia by the Melanocortin-1 Receptor"],"prefix":"10.1097","volume":"112","author":[{"given":"Aaron","family":"Juni","sequence":"first","affiliation":[{"name":"Research Associate, Neuropsychology Doctoral Program, Queens College, City University of New York, Flushing, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minying","family":"Cai","sequence":"additional","affiliation":[{"name":"Professor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Stankova","sequence":"additional","affiliation":[{"name":"Research Associate, Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda\u00a0R.","family":"Waxman","sequence":"additional","affiliation":[{"name":"Ph.D. Student, Neuropsychology Doctoral Program, Queens College, City University of New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Arout","sequence":"additional","affiliation":[{"name":"Ph.D. Student, Neuropsychology Doctoral Program, Queens College, City University of New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gad","family":"Klein","sequence":"additional","affiliation":[{"name":"Research Associate, Neuropsychology Doctoral Program, Queens College, City University of New York, Flushing, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Dahan","sequence":"additional","affiliation":[{"name":"Professor, Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor\u00a0J.","family":"Hruby","sequence":"additional","affiliation":[{"name":"Professor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey\u00a0S.","family":"Mogil","sequence":"additional","affiliation":[{"name":"Professor, Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Kest","sequence":"additional","affiliation":[{"name":"Professor, Neuropsychology Doctoral Program, Queens College, City University of New York, and Department of Psychology and Center for Developmental Neuroscience, The College of Staten Island, City University of New York."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-31-20251014"},{"key":"R2-31-20251014"},{"key":"R3-31-20251014"},{"key":"R4-31-20251014"},{"key":"R5-31-20251014"},{"key":"R6-31-20251014"},{"key":"R7-31-20251014"},{"key":"R8-31-20251014"},{"key":"R9-31-20251014"},{"key":"R10-31-20251014"},{"key":"R11-31-20251014"},{"key":"R12-31-20251014"},{"key":"R13-31-20251014"},{"key":"R14-31-20251014"},{"key":"R15-31-20251014"},{"key":"R16-31-20251014"},{"key":"R17-31-20251014"},{"key":"R18-31-20251014"},{"key":"R19-31-20251014"},{"key":"R20-31-20251014"},{"key":"R21-31-20251014"},{"key":"R22-31-20251014"},{"key":"R23-31-20251014"},{"key":"R24-31-20251014"},{"key":"R25-31-20251014"},{"key":"R26-31-20251014"},{"key":"R27-31-20251014"},{"key":"R28-31-20251014"},{"key":"R29-31-20251014"}],"container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/112\/1\/181\/657360\/0000542-201001000-00031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-201001000-00029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T16:01:02Z","timestamp":1760457662000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-201001000-00029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e3181c53849","relation":{},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1,1]]}}}