{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:31:24Z","timestamp":1790854284584,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2010,4,1]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Conflicting data exist on the renal effects of hydroxyethyl starch (HES) preparations. The current study evaluates the effects of saline-based 6% HES 130\/0.4, 10% HES 200\/0.5, and a balanced isotonic crystalloid on renal function and microscopic changes in ovine endotoxemic shock.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Thirty sheep were subjected to endotoxin infusion (Salmonella typhosa) at incremental doses until mean arterial pressure was less than 65 mmHg. Animals were randomized to receive fluid resuscitation with saline-based 6% HES 130\/0.4, 10% HES 200\/0.5, or a balanced isotonic crystalloid (n = 10 each). Animals surviving the 12-h intervention period were anesthetized and killed. Kidney samples were taken for microscopic analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Endotoxemia was associated with hemoconcentration, protein extravasation, and arterial hypotension. Fluid resuscitation established a hypotensive-hyperdynamic circulation with increased cardiac index and oxygen delivery and decreased afterload. Diuresis was lowest in animals treated with 10% HES 200\/0.5. In addition, plasma creatinine and urea concentrations increased in sheep treated with 10% HES 200\/0.5 (1.2 +\/- 0.1 and 19 +\/- 2 mg\/dl) when compared with the other two groups (0.9 +\/- 0.1 and 15 +\/- 1 mg\/dl, 6% HES 130\/0.4; 0.9 +\/- 0.1 and 15 +\/- 1 mg\/dl, crystalloids; each P &lt; 0.05). Electron microscopic tubular injury score was highest in sheep treated with 10% HES 200\/0.5 (P &lt; 0.001 vs. 6% HES 130\/0.4).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>In ovine endotoxemic shock, saline-based 10% HES 200\/0.5 was linked to impaired renal function and more pronounced tubular epithelial injury when compared with 6% HES 130\/0.4 and balanced crystalloids.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/aln.0b013e3181d3d493","type":"journal-article","created":{"date-parts":[[2010,3,17]],"date-time":"2010-03-17T01:54:34Z","timestamp":1268790874000},"page":"936-947","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":28,"title":["Renal Effects of Saline-based 10% Pentastarch versus\u00a0 6% Tetrastarch Infusion in Ovine Endotoxemic Shock"],"prefix":"10.1097","volume":"112","author":[{"given":"Christian","family":"Ertmer","sequence":"first","affiliation":[{"name":"Resident and Research Fellow."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Professor, Department of Pathology."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rehberg","sequence":"additional","affiliation":[{"name":"Resident and Research Fellow."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Morelli","sequence":"additional","affiliation":[{"name":"Consultant Anesthesiologist and Intensive Care Physician, Department of Anesthesiology and Intensive Care, University of Rome \u201cLa Sapienza,\u201d Rome, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lange","sequence":"additional","affiliation":[{"name":"Associate Professor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Ellger","sequence":"additional","affiliation":[{"name":"Associate Professor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardo\u00a0Bollen","family":"Pinto","sequence":"additional","affiliation":[{"name":"Resident."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"R\u00fcbig","sequence":"additional","affiliation":[{"name":"Medical Student."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Erren","sequence":"additional","affiliation":[{"name":"Consultant, Department of Laboratory Medicine, University of Muenster, Muenster, Germany."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars\u00a0G.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Professor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Van Aken","sequence":"additional","affiliation":[{"name":"Chair and Professor, Department of Anesthesiology and Intensive Care."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Westphal","sequence":"additional","affiliation":[{"name":"Professor."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-26-20251014"},{"key":"R3-26-20251014"},{"key":"R4-26-20251014"},{"key":"R5-26-20251014"},{"key":"R6-26-20251014"},{"key":"R7-26-20251014"},{"key":"R8-26-20251014"},{"key":"R9-26-20251014"},{"key":"R10-26-20251014"},{"key":"R11-26-20251014"},{"key":"R12-26-20251014"},{"key":"R13-26-20251014"},{"key":"R14-26-20251014"},{"key":"R15-26-20251014"},{"key":"R16-26-20251014"},{"key":"R17-26-20251014"},{"key":"R18-26-20251014"},{"key":"R19-26-20251014"},{"key":"R20-26-20251014"},{"key":"R21-26-20251014"},{"key":"R22-26-20251014"},{"key":"R23-26-20251014"},{"key":"R24-26-20251014"},{"key":"R25-26-20251014"},{"key":"R26-26-20251014"},{"key":"R27-26-20251014"},{"key":"R28-26-20251014"},{"key":"R29-26-20251014"},{"key":"R31-26-20251014"}],"container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/112\/4\/936\/250359\/0000542-201004000-00026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-201004000-00024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T16:02:49Z","timestamp":1760457769000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-201004000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,1]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e3181d3d493","relation":{},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4,1]]}}}