{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:06:57Z","timestamp":1768522017527,"version":"3.49.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2010,7,1]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>In recent years, there has been an increased interest in using a multimodal approach with combined agents to treat postoperative nausea and vomiting. This study evaluated whether the addition of an oral dose of the neurokinin-1 receptor antagonist casopitant improved the antiemetic efficacy of an intravenous dose of ondansetron hydrochloride.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The authors enrolled 702 premenopausal or perimenopausal, nonsmoking, female patients aged 18-55 yr with a history of postoperative nausea and vomiting and\/or motion sickness undergoing a laparoscopic or laparotomic gynecologic surgical procedure or laparoscopic cholecystectomy with general anesthesia. Subjects were randomized to one of five treatment arms: standard ondansetron 4 mg with casopitant at 0, 50, 100, or 150 mg, or 0 mg ondansetron with casopitant at 150 mg (the latter arm was considered an exploratory study group and was included in the safety analysis but not in the efficacy analysis).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A significantly greater proportion of patients in all of the active casopitant plus ondansetron groups achieved a complete response (i.e., no vomiting, retching, rescue medication, or premature withdrawal) during the first 24 h postoperatively versus those in the ondansetron-alone group (59-62% vs. 40%, respectively; P = 0.0006). All active doses seemed to be well tolerated; headache, dizziness, and constipation were the most frequently reported adverse events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Compared with ondansetron alone, the casopitant and ondansetron combination results in superior emesis prevention during the first 24 h postoperatively in female patients with known risk factors for postoperative nausea and vomiting.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/aln.0b013e3181d7b13a","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T11:04:54Z","timestamp":1275563094000},"page":"74-82","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":37,"title":["Phase II Study to Evaluate the Safety and Efficacy of the Oral Neurokinin-1 Receptor Antagonist Casopitant (GW679769) Administered with Ondansetron for the Prevention of Postoperative and Postdischarge Nausea and Vomiting in High-risk Patients"],"prefix":"10.1097","volume":"113","author":[{"given":"Neil K.","family":"Singla","sequence":"first","affiliation":[{"name":"Chief Executive Officer."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia K.","family":"Singla","sequence":"additional","affiliation":[{"name":"Chief Operating Officer, Lotus Clinical Research Inc., Huntington Hospital, Pasadena, California."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances","family":"Chung","sequence":"additional","affiliation":[{"name":"Professor, Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demetrios J.","family":"Kutsogiannis","sequence":"additional","affiliation":[{"name":"Associate Professor, Division of Critical Care Medicine, University of Alberta, Edmonton, Alberta, Canada."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Blackburn","sequence":"additional","affiliation":[{"name":"Associate Director."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Lane","sequence":"additional","affiliation":[{"name":"Statistician."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremey","family":"Levin","sequence":"additional","affiliation":[{"name":"Director."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Johnson","sequence":"additional","affiliation":[{"name":"Principal Clinical Pharmacokineticist, Clinical Pharmacology Modeling & Simulation, GlaxoSmithKline, Collegeville, Pennsylvania."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph V.","family":"Pergolizzi","sequence":"additional","affiliation":[{"name":"Adjunct Assistant Professor, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, and Adjunct Faculty, Department of Anesthesia, Georgetown University School of Medicine, Washington, D.C."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-13-20250520"},{"key":"R2-13-20250520"},{"key":"R3-13-20250520"},{"key":"R4-13-20250520"},{"key":"R5-13-20250520"},{"key":"R6-13-20250520"},{"key":"R7-13-20250520"},{"key":"R8-13-20250520"},{"key":"R9-13-20250520"},{"key":"R10-13-20250520"},{"key":"R11-13-20250520"},{"key":"R12-13-20250520"},{"key":"R13-13-20250520"},{"key":"R14-13-20250520"},{"key":"R15-13-20250520"},{"key":"R16-13-20250520"},{"key":"R17-13-20250520"},{"key":"R18-13-20250520"},{"key":"R19-13-20250520"},{"key":"R20-13-20250520"},{"key":"R21-13-20250520"},{"key":"R22-13-20250520"},{"key":"R23-13-20250520"},{"key":"R24-13-20250520"},{"key":"R25-13-20250520"}],"container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/113\/1\/74\/658126\/0000542-201007000-00013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-201007000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T11:07:14Z","timestamp":1747739234000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-201007000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e3181d7b13a","relation":{},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7,1]]}}}