{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:28:21Z","timestamp":1785274101565,"version":"3.55.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2011,5,1]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The interleukin-1 receptor antagonist (IL-1Ra) is the principal determinant of IL-1\u03b2 bioactivity within the IL-1 gene cluster, regulating IL-1\u03b1 and IL-1\u03b2 release. This study was designed to determine whether polymorphisms of the IL-1Ra gene (IL1RN) produce clinically measurable differences in serum IL-1Ra concentrations and opioid consumption in the postoperative period.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Opioid consumption and pain scores were evaluated in 96 patients undergoing a nephrectomy. DNA was extracted from all patients, and the genotypes of IL1RN were determined by polymerase chain reaction amplification of the variable number of tandem repeats of 86 base pairs in intron 2 of IL1RN. The concentrations of serum IL-1Ra concentrations at baseline and at 24 h postoperatively in 58 subjects were measured.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Differences in opioid consumption among the three genotype groups (IL1RN*1 homozygotes and *2 and *3 carriers) were statistically significant in the first and second 12-h postoperative periods (P = 0.010). The IL1RN*2 carrier group consumed 43% (95% CI, 38-48%) less opioids in the first 24 h after surgery than the IL1RN*1 homozygote group (P = 0.003). Differences in the serum IL-1Ra concentration among the three genotype groups were statistically significant at 24 h postoperatively (P = 0.003), with IL1RN*2 carriers having the highest serum IL-1Ra concentrations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The variable number of tandem repeats in intron 2 of IL1RN may contribute to interindividual variations in opioid consumption in the first 24 h after surgery. Patients homozygous for the IL1RN*1 allele have lower concentrations of IL-1Ra and require higher doses of opioids postoperatively than patients carrying at least one IL1RN*2 allele.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/aln.0b013e318216e9cb","type":"journal-article","created":{"date-parts":[[2011,3,31]],"date-time":"2011-03-31T02:44:15Z","timestamp":1301539455000},"page":"1162-1168","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":28,"title":["Polymorphism in the Interleukin-1 Receptor Antagonist Gene Is Associated with Serum Interleukin-1 Receptor Antagonist Concentrations and Postoperative Opioid Consumption"],"prefix":"10.1097","volume":"114","author":[{"given":"Keith A.","family":"Candiotti","sequence":"first","affiliation":[{"name":"Professor, Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami, Miller School of Medicine, Miami, Florida."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Assistant Scientist."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Morris","sequence":"additional","affiliation":[{"name":"Voluntary Associate Professor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Yang","sequence":"additional","affiliation":[{"name":"Postdoctoral Fellow."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas A.","family":"Crescimone","sequence":"additional","affiliation":[{"name":"Postdoctoral Fellow."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greys C.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Postdoctoral Fellow and Resident\/Fellow."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Bird","sequence":"additional","affiliation":[{"name":"Associate Professor."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Leveillee","sequence":"additional","affiliation":[{"name":"Professor, Department of Urology, University of Miami, Miller School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiliam","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Resident\/Fellow, Department of Human Genetics, University of Miami, Miller School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanliang","family":"Liu","sequence":"additional","affiliation":[{"name":"Assistant Professor, Department of Microbiology and Immunology, University of Miami, Miller School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Dana","family":"Zhang","sequence":"additional","affiliation":[{"name":"Assistant Professor, Division of Hematology\/Oncology, Department of Medicine, University of Miami, Miller School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Bethea","sequence":"additional","affiliation":[{"name":"Associate Professor, Departments of Microbiology and Immunology and Neurological Surgery, University of Miami, Miller School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin C.","family":"Gitlin","sequence":"additional","affiliation":[{"name":"Professor, Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami, Miller School of Medicine, Miami, Florida."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-28-20251014"},{"key":"R2-28-20251014"},{"key":"R3-28-20251014"},{"key":"R4-28-20251014"},{"key":"R5-28-20251014"},{"key":"R6-28-20251014"},{"key":"R7-28-20251014"},{"key":"R9-28-20251014"},{"key":"R10-28-20251014"},{"key":"R11-28-20251014"},{"key":"R12-28-20251014"},{"key":"R13-28-20251014"},{"key":"R14-28-20251014"},{"key":"R15-28-20251014"},{"key":"R16-28-20251014"},{"key":"R17-28-20251014"},{"key":"R18-28-20251014"},{"key":"R19-28-20251014"},{"key":"R20-28-20251014"},{"key":"R21-28-20251014"}],"container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/114\/5\/1162\/254382\/0000542-201105000-00028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-201105000-00026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T16:00:50Z","timestamp":1760457650000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-201105000-00026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,1]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e318216e9cb","relation":{},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5,1]]}}}