{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:37:33Z","timestamp":1791128253759,"version":"4.1.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Normovolemic hemodilution is known to inhibit hypoxic pulmonary vasoconstriction. How the coupling between the pulmonary arterial (PA) circulation and the right ventricle (RV) is affected by normovolemic hemodilution and by the composition of replacement solutions remains unknown. Therefore, the effects of isotonic and hypertonic saline hydroxyethylstarch solutions on the pulmonary circulation and RV, in control and hypoxic conditions, were compared.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Anesthetized piglets (n = 14) were equipped with manometer-tipped catheters in the RV and main PA and an ultrasonic flow probe around the main PA. The pulmonary circulation was assessed by pressure-flow relations and vascular impedance, RV afterload by effective arterial elastance (Ea), RV contractility by end-systolic elastance (Ees), and RV-PA coupling by the Ees\/Ea ratio. Measurements were done in control (Fio2 0.40) and hypoxic (Fio2 0.12) conditions before and after acute normovolemic hemodilution with either 20 ml\/kg isotonic saline hydroxyethylstarch (hydroxyethylstarch 130\/0.4 6% in NaCl 0.9%, Voluven, Fresenius-Kabi, Sevres, France) or 5 ml\/kg hypertonic saline hydroxyethylstarch (hydroxyethylstarch 200\/0.5 6% in NaCl 7.2%, HyperHES, Fresenius-Kabi) solutions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Hypoxic pulmonary vasoconstriction was associated with proportional increases in Ea and Ees and did not affect RV-PA coupling. Hemodilution attenuated the hypoxic response. Hemodilution with isotonic saline hydroxyethylstarch did not affect the RV-PA coupling, whereas hemodilution with hypertonic saline hydroxyethylstarch increased Ees and the Ees\/Ea ratio.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>In experimental normovolemic hemodilution, both in control and in hypoxic conditions, RV-PA coupling is unaffected by isotonic saline hydroxyethylstarch but improved by hypertonic saline hydroxyethylstarch, mainly because of an increase in RV contractility.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/aln.0b013e31821bdb69","type":"journal-article","created":{"date-parts":[[2011,5,17]],"date-time":"2011-05-17T09:32:57Z","timestamp":1305624777000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Hypertonic Saline Hydroxyethylstarch Restores Right Ventricular-Arterial Coupling after Normovolemic Hemodilution in Piglets"],"prefix":"10.1097","volume":"115","author":[{"given":"Fran\u00e7ois","family":"Kerbaul","sequence":"first","affiliation":[{"name":"Professor, Service d'Anesth\u00e9sie-R\u00e9animation Adultes, H\u00f4pital La Timone, Marseille and UMR MD2 PCO2E, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de la M\u00e9diterran\u00e9e, Aix-Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Rondelet","sequence":"additional","affiliation":[{"name":"Associate Professor, Department of Thoracic Surgery, Erasme Hospital and Laboratory of Physiology, Free University of Brussels, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"B\u00e9nas","sequence":"additional","affiliation":[{"name":"Fellow, Service d'Anesth\u00e9sie-R\u00e9animation Adultes, H\u00f4pital La Timone, Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Grisoli","sequence":"additional","affiliation":[{"name":"Fellow, Service de Chirurgie Cardiaque, H\u00f4pital La Timone."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"De Waroquier","sequence":"additional","affiliation":[{"name":"Fellow, Service d'Anesth\u00e9sie-R\u00e9animation, H\u00f4pital d'Instruction des Arm\u00e9es Alphonse Laveran, Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fesler","sequence":"additional","affiliation":[{"name":"Service de Medecine Interne, H\u00f4pital Lapeyronnie, Montpellier, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fusai","sequence":"additional","affiliation":[{"name":"Professor, Institut de M\u00e9decine Tropicale, Service de Sant\u00e9 des Arm\u00e9es, Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Brimioulle","sequence":"additional","affiliation":[{"name":"Professor, Department of Intensive Care, Erasme Hospital and Laboratory of Physiology, Free University of Brussels."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-26-20251013"},{"key":"R2-26-20251013"},{"key":"R3-26-20251013"},{"key":"R4-26-20251013"},{"key":"R5-26-20251013"},{"key":"R6-26-20251013"},{"key":"R7-26-20251013"},{"key":"R8-26-20251013"},{"key":"R9-26-20251013"},{"key":"R11-26-20251013"},{"key":"R12-26-20251013"},{"key":"R14-26-20251013"},{"key":"R15-26-20251013"},{"key":"R16-26-20251013"},{"key":"R17-26-20251013"},{"key":"R18-26-20251013"},{"key":"R19-26-20251013"},{"key":"R20-26-20251013"},{"key":"R21-26-20251013"},{"key":"R22-26-20251013"},{"key":"R23-26-20251013"},{"key":"R24-26-20251013"},{"key":"R25-26-20251013"},{"key":"R26-26-20251013"},{"key":"R27-26-20251013"},{"key":"R28-26-20251013"},{"key":"R29-26-20251013"},{"key":"R30-26-20251013"},{"key":"R31-26-20251013"},{"key":"R32-26-20251013"},{"key":"R33-26-20251013"},{"key":"R34-26-20251013"},{"key":"R35-26-20251013"}],"container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/115\/1\/136\/254842\/0000542-201107000-00026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-201107000-00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T18:05:59Z","timestamp":1760378759000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-201107000-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e31821bdb69","relation":{},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,1]]}}}