{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:28:46Z","timestamp":1793237326359,"version":"4.5.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2011,9,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Predicting fluid responsiveness remains a difficult question in hemodynamically unstable patients. The author's objective was to test whether noninvasive assessment by transthoracic echocardiography of subaortic velocity time index (VTI) variation after a low volume of fluid infusion (100 ml hydroxyethyl starch) can predict fluid responsiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-nine critically ill ventilated and sedated patients with acute circulatory failure were prospectively studied. Subaortic VTI was measured by transthoracic echocardiography before fluid infusion (baseline), after 100 ml hydroxyethyl starch infusion over 1 min, and after an additional infusion of 400 ml hydroxyethyl starch over 14 min. The authors measured the variation of VTI after 100 ml fluid (\u0394VTI 100) for each patient. Receiver operating characteristic curves were generated for (\u0394VTI 100). When available, receiver operating characteristic curves also were generated for pulse pressure variation and central venous pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After 500 ml volume expansion, VTI increased \u2265 15% in 21 patients (54%) defined as responders. \u0394VTI 100 \u2265 10% predicted fluid responsiveness with a sensitivity and specificity of 95% and 78%, respectively. The area under the receiver operating characteristic curves of \u0394VTI 100 was 0.92 (95% CI: 0.78-0.98). In 29 patients, pulse pressure variation and central venous pressure also were available. In this subgroup of patients, the area under the receiver operating characteristic curves for \u0394VTI 100, pulse pressure variation, and central venous pressure were 0.90 (95% CI: 0.74-0.98, P &lt; 0.05), 0.55 (95% CI: 0.35-0.73, NS), and 0.61 (95% CI: 0.41-0.79, NS), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with low volume mechanical ventilation and acute circulatory failure, \u0394VTI 100 accurately predicts fluid responsiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/aln.0b013e318229a500","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T04:29:05Z","timestamp":1311654545000},"page":"541-547","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":288,"title":["An Increase in Aortic Blood Flow after an Infusion of 100 ml Colloid over 1 Minute Can Predict Fluid Responsiveness"],"prefix":"10.1097","volume":"115","author":[{"given":"Laurent","family":"Muller","sequence":"first","affiliation":[{"name":"Staff Anesthesiologist and Intensivist, Division Anesth\u00e9sie R\u00e9animation Urgences Douleur, Groupe Hospitalo-Universitaire Caremeau, CHU N\u00eemes, Place du Professeur Robert Debr\u00e9, N\u00eemes, France; Facult\u00e9 de M\u00e9decine, Universit\u00e9 Montpellier 1 Equipe d'Accueil 2992, Laboratoire de Physiologie Cardiovasculaire et d'Anesth\u00e9sie Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, Place du Professeur Robert Debr\u00e9, N\u00eemes."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medhi","family":"Toumi","sequence":"additional","affiliation":[{"name":"Staff Anesthesiologist and Intensivist, Division Anesth\u00e9sie R\u00e9animation Urgences Douleur, Groupe Hospitalo-Universitaire Caremeau, CHU N\u00eemes, Place du Professeur Robert Debr\u00e9, N\u00eemes, France; Facult\u00e9 de M\u00e9decine, Universit\u00e9 Montpellier 1 Equipe d'Accueil 2992, Laboratoire de Physiologie Cardiovasculaire et d'Anesth\u00e9sie Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, Place du Professeur Robert Debr\u00e9, N\u00eemes."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe-Jean","family":"Bousquet","sequence":"additional","affiliation":[{"name":"Biostatistician, D\u00e9partement Biostatistiques Epid\u00e9miologie Clinique Sant\u00e9 Publique Information M\u00e9dicale, CHU N\u00eemes, Place du Professeur Robert Debr\u00e9; Facult\u00e9 de M\u00e9decine, Universit\u00e9 Montpellier 1."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Riu-Poulenc","sequence":"additional","affiliation":[{"name":"Staff Intensivist, Service Anesth\u00e9sie R\u00e9animation, H\u00f4pital Purpan, Place du Docteur Baylac, Toulouse, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Louart","sequence":"additional","affiliation":[{"name":"Staff Anesthesiologist and Intensivist, Division Anesth\u00e9sie R\u00e9animation Urgences Douleur, Groupe Hospitalo-Universitaire Caremeau, CHU N\u00eemes, Place du Professeur Robert Debr\u00e9, N\u00eemes, France; Facult\u00e9 de M\u00e9decine, Universit\u00e9 Montpellier 1 Equipe d'Accueil 2992, Laboratoire de Physiologie Cardiovasculaire et d'Anesth\u00e9sie Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, Place du Professeur Robert Debr\u00e9, N\u00eemes."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Candela","sequence":"additional","affiliation":[{"name":"Staff Anesthesiologist and Intensivist, Division Anesth\u00e9sie R\u00e9animation Urgences Douleur, Groupe Hospitalo-Universitaire Caremeau, CHU N\u00eemes, Place du Professeur Robert Debr\u00e9, N\u00eemes, France; Facult\u00e9 de M\u00e9decine, Universit\u00e9 Montpellier 1 Equipe d'Accueil 2992, Laboratoire de Physiologie Cardiovasculaire et d'Anesth\u00e9sie Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, Place du Professeur Robert Debr\u00e9, N\u00eemes."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lana","family":"Zoric","sequence":"additional","affiliation":[{"name":"Staff Anesthesiologist and Intensivist, Division Anesth\u00e9sie R\u00e9animation Urgences Douleur, Groupe Hospitalo-Universitaire Caremeau, CHU N\u00eemes, Place du Professeur Robert Debr\u00e9, N\u00eemes, France; Facult\u00e9 de M\u00e9decine, Universit\u00e9 Montpellier 1 Equipe d'Accueil 2992, Laboratoire de Physiologie Cardiovasculaire et d'Anesth\u00e9sie Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, Place du Professeur Robert Debr\u00e9, N\u00eemes."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carey","family":"Suehs","sequence":"additional","affiliation":[{"name":"Biostatistician, D\u00e9partement Biostatistiques Epid\u00e9miologie Clinique Sant\u00e9 Publique Information M\u00e9dicale, CHU N\u00eemes, Place du Professeur Robert Debr\u00e9; Facult\u00e9 de M\u00e9decine, Universit\u00e9 Montpellier 1."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Emmanuel","family":"de La Coussaye","sequence":"additional","affiliation":[{"name":"Professor of Anesthesiology and Critical Care Medicine, Division Anesth\u00e9sie R\u00e9animation Urgences Douleur, Groupe Hospitalo-Universitaire Caremeau, CHU N\u00eemes, Place du Professeur Robert Debr\u00e9; Facult\u00e9 de M\u00e9decine, Universit\u00e9 Montpellier 1 Equipe d'Accueil 2992, Laboratoire de Physiologie Cardiovasculaire et d'Anesth\u00e9sie Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, Place du Professeur Robert Debr\u00e9."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Molinari","sequence":"additional","affiliation":[{"name":"Biostatistician, D\u00e9partement Biostatistiques Epid\u00e9miologie Clinique Sant\u00e9 Publique Information M\u00e9dicale, CHU N\u00eemes, Place du Professeur Robert Debr\u00e9; Facult\u00e9 de M\u00e9decine, Universit\u00e9 Montpellier 1."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Lefrant","sequence":"additional","affiliation":[{"name":"Professor of Anesthesiology and Critical Care Medicine, Division Anesth\u00e9sie R\u00e9animation Urgences Douleur, Groupe Hospitalo-Universitaire Caremeau, CHU N\u00eemes, Place du Professeur Robert Debr\u00e9; Facult\u00e9 de M\u00e9decine, Universit\u00e9 Montpellier 1 Equipe d'Accueil 2992, Laboratoire de Physiologie Cardiovasculaire et d'Anesth\u00e9sie Exp\u00e9rimentale, Facult\u00e9 de M\u00e9decine, Place du Professeur Robert Debr\u00e9."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/115\/3\/541\/255068\/0000542-201109000-00019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-201109000-00015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T18:02:53Z","timestamp":1760378573000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-201109000-00015"}},"subtitle":["The Mini-fluid Challenge Study"],"short-title":[],"issued":{"date-parts":[[2011,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e318229a500","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13276965.14635064","asserted-by":"object"}]},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9,1]]}}}