{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:59:48Z","timestamp":1792799988777,"version":"4.5.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"\n Background<\/jats:title>\n Chronic pain is associated with depression. In rodents, pain is often assessed by sensory hypersensitivity, which does not sufficiently measure affective responses. Low-dose ketamine has been used to treat both pain and depression, but it is not clear whether ketamine can relieve depression associated with chronic pain and whether this antidepressant effect depends on its antinociceptive properties.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The authors examined whether the spared nerve injury model of neuropathic pain induces depressive behavior in rats, using sucrose preference test and forced swim test, and tested whether a subanesthetic dose of ketamine treats spared nerve injury-induced depression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Spared nerve injury-treated rats, compared with control rats, showed decreased sucrose preference (0.719 \u00b1 0.068 (mean \u00b1 SEM) vs. 0.946 \u00b1 0.010) and enhanced immobility in the forced swim test (107.3 \u00b1 14.6s vs. 56.2 \u00b1 12.5s). Further, sham-operated rats demonstrated depressive behaviors in the acute postoperative period (0.790 \u00b1 0.062 on postoperative day 2). A single subanesthetic dose of ketamine (10 mg\/kg) did not alter spared nerve injury-induced hypersensitivity; however, it treated spared nerve injury-associated depression-like behaviors (0.896 \u00b1 0.020 for ketamine vs. 0.663 \u00b1 0.080 for control rats 1 day after administration; 0.858 \u00b1 0.017 for ketamine vs. 0.683 \u00b1 0.077 for control rats 5 days after administration).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Chronic neuropathic pain leads to depression-like behaviors. The postoperative period also confers vulnerability to depression, possibly due to acute pain. Sucrose preference test and forced swim test may be used to compliment sensory tests for assessment of pain in animal studies. Low-dose ketamine can treat depression-like behaviors induced by chronic neuropathic pain.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/aln.0b013e31822f16ae","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T22:44:31Z","timestamp":1317768271000},"page":"812-821","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":157,"title":["A Single Subanesthetic Dose of Ketamine Relieves Depression-like Behaviors Induced by Neuropathic Pain in Rats"],"prefix":"10.1097","volume":"115","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Assistant Professor, Department of Anesthesiology, New York University School of Medicine, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yossef","family":"Goffer","sequence":"additional","affiliation":[{"name":"Research Assistant, Department of Anesthesiology, New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Xu","sequence":"additional","affiliation":[{"name":"Research Assistant, Department of Anesthesiology, New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0S.","family":"Tukey","sequence":"additional","affiliation":[{"name":"Postdoctoral Fellow, Department of Biochemistry, New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.\u00a0B.","family":"Shamir","sequence":"additional","affiliation":[{"name":"Graduate Student, Sackler Graduate Program, New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah\u00a0E.","family":"Eberle","sequence":"additional","affiliation":[{"name":"Research Assistant, Department of Anesthesiology, New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony\u00a0H.","family":"Zou","sequence":"additional","affiliation":[{"name":"Undergraduate Student, Columbia College, New York, New York."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.\u00a0J.","family":"Blanck","sequence":"additional","affiliation":[{"name":"Dorothy Reaves Spatz, M.D. Professor and Chair, Department of Anesthesiology, New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward\u00a0B.","family":"Ziff","sequence":"additional","affiliation":[{"name":"Professor, Department of Biochemistry, New York University School of Medicine."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/115\/4\/812\/255000\/0000542-201110000-00033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-201110000-00029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T11:00:21Z","timestamp":1747738821000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-201110000-00029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e31822f16ae","relation":{},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10,1]]}}}