{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:06:42Z","timestamp":1791320802618,"version":"4.3.1"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Anesthesiology"],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Colistin often remains the only active agent against multidrug-resistant Gram-negative pathogens. The aim of the study was to assess efficacy of nebulized colistin for treating ventilator-associated pneumonia (VAP) caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>One hundred and sixty-five patients with VAP caused by P. aeruginosa and A. baumannii were enrolled in a prospective, observational, and comparative study. The sensitive strain group included 122 patients with VAP caused by P. aeruginosa and A. baumannii susceptible to \u03b2-lactams, aminoglycosides, or quinolones and treated with intravenous antibiotics for 14 days. The multidrug-resistant strain group included 43 patients with VAP caused by multidrug-resistant P. aeruginosa and A. baumannii and treated with nebulized colistin (5 million international units every 8 h) either in monotherapy (n=28) or combined to a 3-day intravenous aminoglycosides for 7-19 days. The primary endpoint was clinical cure rate. Aerosol was delivered using vibrating plate nebulizer.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>After treatment, clinical cure rate was 66% in sensitive strain group and 67% in multidrug-resistant strain group (difference -1%, lower limit of 95% CI for difference -12.6%). Mortality was not different between groups (23 vs. 16%). Among 16 patients with persisting or recurrent P. aeruginosa infection, colistin minimum inhibitory concentration increased in two patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Nebulization of high-dose colistin was effective to treat VAP caused by multidrug-resistant P. aeruginosa or A. baumannii. Its therapeutic effect was noninferior to intravenous \u03b2-lactams associated with aminoglycosides or quinolones for treating VAP caused by susceptible P. aeruginosa and A. baumannii.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/aln.0b013e31827515de","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T10:19:14Z","timestamp":1352197154000},"page":"1335-1347","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":178,"title":["Efficacy of High-dose Nebulized Colistin in Ventilator-associated Pneumonia Caused by Multidrug-resistant Pseudomonas aeruginosa\u00a0 and Acinetobacter baumannii\u00a0"],"prefix":"10.1097","volume":"117","author":[{"given":"Qin","family":"Lu","sequence":"first","affiliation":[{"name":"Praticiens Hospitaliers."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubin","family":"Luo","sequence":"additional","affiliation":[{"name":"Research Assistant, Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China.Praticien Hospitalier, Department of Pharmacology, La Piti\u00e9-Salp\u00eatri\u00e8re Hospital, UPMC Univ, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliane","family":"Bodin","sequence":"additional","affiliation":[{"name":"Praticiens Hospitaliers."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Research Assistant, Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China.Praticien Hospitalier, Department of Pharmacology, La Piti\u00e9-Salp\u00eatri\u00e8re Hospital, UPMC Univ, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00ebl","family":"Zahr","sequence":"additional","affiliation":[{"name":"Research Assistant, Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China.Praticien Hospitalier, Department of Pharmacology, La Piti\u00e9-Salp\u00eatri\u00e8re Hospital, UPMC Univ, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Aubry","sequence":"additional","affiliation":[{"name":"Maitre de Conf\u00e9rence des Universit\u00e9s-Praticien Hospitalier, Department of Bacteriology, La Piti\u00e9-Salp\u00eatri\u00e8re Hospital, UPMC Univ."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Golmard","sequence":"additional","affiliation":[{"name":"Maitre de Conf\u00e9rence des Universit\u00e9s-Praticien Hospitalier, ER4 \u201cMod\u00e9lisation en recherche clinique\u201d Universit\u00e9 Pierre et Marie Curie et UF de Biostatistique, La Piti\u00e9-Salp\u00eatri\u00e8re Hospital, UPMC UnivSee the appendix for members of the Nebulized Antibiotics Study Group."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Rouby","sequence":"additional","affiliation":[{"name":"Professor of Anesthesiology and Critical Care and Medical Director of the Intensive Care Unit, Department of Anesthesiology and Critical Care Medicine, Multidisciplinary Intensive Care Unit Pierre Viars, La Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Assistance-Publique-H\u00f4pitaux-de-Paris, UPMC Univ, Paris, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/117\/6\/1335\/258986\/0000542-201212000-00027.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.lww.com\/00000542-201212000-00031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T10:50:41Z","timestamp":1747738241000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000542-201212000-00031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e31827515de","relation":{},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12,1]]}}}