{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:22:10Z","timestamp":1790644930705,"version":"4.1.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The efficacy of local anesthetic wound infiltration for the treatment of acute and chronic postoperative pain is controversial and there are no detailed studies. The primary objective of this study was to evaluate the influence of ropivacaine wound infiltration on chronic pain after breast surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this prospective, randomized, double-blind, parallel-group, placebo-controlled study, 236 patients scheduled for breast cancer surgery were randomized (1:1) to receive ropivacaine or placebo infiltration of the wound, the second and third intercostal spaces and the humeral insertion of major pectoralis. Acute pain, analgesic consumption, nausea and vomiting were assessed every 30 min for 2 h in the postanesthesia care unit and every 6 h for 48 h. Chronic pain was evaluated 3 months, 6 months, and 1 yr after surgery by the brief pain inventory, hospital anxiety and depression, and neuropathic pain questionnaires.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Ropivacaine wound infiltration significantly decreased immediate postoperative pain for the first 90 min, but did not decrease chronic pain at 3 months (primary endpoint), or at 6 and 12 months postoperatively. At 3 months, the incidence of chronic pain was 33% and 27% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.37) in the ropivacaine and placebo groups, respectively. During follow-up, brief pain inventory, neuropathic pain, and anxiety increased over time in both groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) while depression remained stable. No complications occurred.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This multicenter, prospective study shows that ropivacaine wound infiltration after breast cancer surgery decreased immediate postoperative pain but did not decrease chronic pain at 3, 6, and 12 months postoperatively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/aln.0b013e31827d88d8","type":"journal-article","created":{"date-parts":[[2013,1,23]],"date-time":"2013-01-23T06:54:28Z","timestamp":1358924068000},"page":"318-326","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":75,"title":["A Double-blind Randomized Trial of Wound and Intercostal Space Infiltration with Ropivacaine during Breast Cancer Surgery"],"prefix":"10.1097","volume":"118","author":[{"given":"Aline","family":"Albi-Feldzer","sequence":"first","affiliation":[{"name":"Professional Staff, Department of Anesthesia and Intensive Care, Institut Godinot, Reims, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Mouret-Fourme E","sequence":"additional","affiliation":[{"name":"Professional Staff, Department of Anesthesia and Intensive Care, Institut Gustave Roussy, Villejuif, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smail","family":"Hamouda","sequence":"additional","affiliation":[{"name":"Professional Staff, Department of Anesthesia and Intensive Care, Institut Curie-H\u00f4pital Ren\u00e9 Huguenin, Saint-Cloud, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrus","family":"Motamed","sequence":"additional","affiliation":[{"name":"Professional Staff, Clinical Epidemiology, Institut Curie-H\u00f4pital Ren\u00e9 Huguenin."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Dubois","sequence":"additional","affiliation":[{"name":"Professional Staff, Department of Anesthesia and Intensive Care, Paoli Calmette, Marseille, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludivine","family":"Jouanneau","sequence":"additional","affiliation":[{"name":"Professional Staff, Department of Anesthesia and Intensive Care, Institut Gustave Roussy, Villejuif, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jayr","sequence":"additional","affiliation":[{"name":"Professional Staff, Department of Anesthesia and Intensive Care, Institut Godinot, Reims, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250520","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/bjs.5103","article-title":"Surgical management of chronic pain after inguinal hernia repair.","volume":"92","year":"2005","journal-title":"Br J Surg"},{"key":"R2-20250520","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/bja\/aei019","article-title":"Chronic postoperative pain: The case of inguinal herniorrhaphy.","volume":"95","year":"2005","journal-title":"Br J Anaesth"},{"key":"R3-20250520","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1001\/jama.2009.1568","article-title":"Prevalence of and factors associated with persistent pain following breast cancer surgery.","volume":"302","year":"2009","journal-title":"JAMA"},{"key":"R4-20250520","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/bja\/87.1.88","article-title":"Chronic pain after surgery.","volume":"87","year":"2001","journal-title":"Br J Anaesth"},{"key":"R5-20250520","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/bja\/aen099","article-title":"Chronic post-surgical pain: 10 years on.","volume":"101","year":"2008","journal-title":"Br J Anaesth"},{"key":"R6-20250520","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/00000542-200010000-00038","article-title":"Chronic pain as an outcome of surgery. 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