{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:08:59Z","timestamp":1784837339073,"version":"3.55.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,9]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Mechanical ventilation is necessary during acute respiratory distress syndrome, but it promotes lung injury because of the excessive stretch applied to the aerated parenchyma. The authors\u2019 hypothesis was that after a regional lung injury, the noxious effect of mechanical ventilation on the remaining aerated parenchyma would be more pronounced.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Mice, instilled with hydrochloric acid (HCl) in the right lung, was assigned to one of the following groups: mechanical ventilation with tidal volumes (V\n T<\/jats:sub>\n ) 25\u2009ml\/kg (HCl-VILI\n 25<\/jats:sub>\n , n = 12), or V\n T<\/jats:sub>\n 15\u2009ml\/kg (HCl-VILI\n 15<\/jats:sub>\n , n = 9), or spontaneous breathing (HCl-SB, n = 14). Healthy mice were ventilated with V\n T<\/jats:sub>\n 25\u2009ml\/kg (VILI\n 25<\/jats:sub>\n , n = 11). Arterial oxygenation, lung compliance, bronchoalveolar lavage inflammatory cells, albumin, and cytokines concentration were measured.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n After 7\u2009h, oxygenation and lung compliance resulted lower in HCl-VILI\n 25<\/jats:sub>\n than in VILI\n 25<\/jats:sub>\n (\n P<\/jats:italic>\n < 0.05, 210\u2009\u00b1\u200954\n vs<\/jats:italic>\n . 479\u2009\u00b1\u200983 mmHg, and 32\u2009\u00b1\u20093.5\n vs<\/jats:italic>\n . 45\u2009\u00b1\u20094.1 \u00b5l\/cm H\n 2<\/jats:sub>\n O, mean \u00b1 SD, respectively). After right lung injury, the left lung of HCl-VILI\n 25<\/jats:sub>\n group received a greater fraction of the V\n T<\/jats:sub>\n than the VILI\n 25<\/jats:sub>\n group, despite an identical global V\n T<\/jats:sub>\n . The number of total and polymorphonuclear cells in bronchoalveolar lavage resulted significantly higher in HCl-VILI\n 25,<\/jats:sub>\n compared with the other groups, in not only the right lung, but also in the left lung. The albumin content in the left lung resulted higher in HCl-VILI\n 25<\/jats:sub>\n than in VILI\n 25<\/jats:sub>\n (224\u2009\u00b1\u200985\n vs<\/jats:italic>\n . 33\u2009\u00b1\u20096 \u00b5g\/ml;\n P<\/jats:italic>\n < 0.05). Cytokines levels did not differ between groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Aggressive mechanical ventilation aggravates the preexisting lung injury, which is noxious for the contralateral, not previously injured lung, possibly because of a regional redistribution of V\n T<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/aln.0b013e318297d487","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T12:56:20Z","timestamp":1368622580000},"page":"642-651","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":18,"title":["Unilateral Acid Aspiration Augments the Effects of Ventilator Lung Injury in the Contralateral Lung"],"prefix":"10.1097","volume":"119","author":[{"given":"Maria","family":"Amigoni","sequence":"first","affiliation":[{"name":"Staff Physician, Department of Emergency, San Gerardo Hospital, Monza (MB), Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Bellani","sequence":"additional","affiliation":[{"name":"Staff Physician, Department of Emergency, San Gerardo Hospital, and Researcher, Department of Health Science, University of Milano-Bicocca, Monza (MB), Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Zambelli","sequence":"additional","affiliation":[{"name":"Research Fellow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita","family":"Scanziani","sequence":"additional","affiliation":[{"name":"Resident"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Farina","sequence":"additional","affiliation":[{"name":"Research Fellow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorella","family":"Fagnani","sequence":"additional","affiliation":[{"name":"Resident"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Latini","sequence":"additional","affiliation":[{"name":"Research Scientist, Department of Cardiovascular Research, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Associate Professor of Anesthesia, Department of Health Science, University of Milano-Bicocca."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pesenti","sequence":"additional","affiliation":[{"name":"Professor of Anesthesia, Department of Health Science, University of Milano-Bicocca, and Director, Department of Emergency, San Gerardo Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20241223","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. 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