{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:06:17Z","timestamp":1790305577128,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Obstructive sleep apnea (OSA) may worsen postoperatively. The objective of this randomized open-label trial is to determine whether perioperative auto-titrated continuous positive airway pressure (APAP) treatment decreases postoperative apnea hypopnea index (AHI) and improves oxygenation in patients with moderate and severe OSA.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>The consented patients with AHI of more than 15 events\/h on preoperative polysomnography were randomized into the APAP or control group (receiving routine care). The APAP patients received APAP for 2 or 3 preoperative, and 5 postoperative nights. All patients were monitored with oximetry for 7 to 8 nights (N) and underwent polysomnography on postoperative N3. The primary outcome was AHI on the postoperative N3.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>One hundred seventy-seven OSA patients undergoing orthopedic and other surgeries were enrolled (APAP: 87 and control: 90). There was no difference between the two groups in baseline data. One hundred six patients (APAP: 40 and control: 66) did polysomnography on postoperative N3, and 100 patients (APAP: 39 and control: 61) completed the study. The compliance rate of APAP was 45%. The APAP usage was 2.4\u20134.6 h\/night. In the APAP group, AHI decreased from preoperative baseline: 30.1 (22.1, 42.5) events\/h (median [25th, 75th percentile]) to 3.0 (1.0, 12.5) events\/h on postoperative N3 (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001), whereas, in the control group, AHI increased from 30.4 (23.2, 41.9) events\/h to 31.9 (13.5, 50.2) events\/h, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.302. No significant change occurred in the central apnea index.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>The trial showed the feasibility of perioperative APAP for OSA patients. Perioperative APAP treatment significantly reduced postoperative AHI and improved oxygen saturation in the patients with moderate and severe OSA.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/aln.0b013e318297d89a","type":"journal-article","created":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T10:51:28Z","timestamp":1379501488000},"page":"837-847","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":99,"title":["Perioperative Auto-titrated Continuous Positive Airway Pressure Treatment in Surgical Patients with Obstructive Sleep Apnea"],"prefix":"10.1097","volume":"119","author":[{"given":"Pu","family":"Liao","sequence":"first","affiliation":[{"name":"Research Analyst"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanwei","family":"Luo","sequence":"additional","affiliation":[{"name":"Research Fellow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisham","family":"Elsaid","sequence":"additional","affiliation":[{"name":"Research Fellow"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weimin","family":"Kang","sequence":"additional","affiliation":[{"name":"Registered Polysomnography Technologist, Department of Anesthesia, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin M.","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Professor, Department of Psychiatry"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Chung","sequence":"additional","affiliation":[{"name":"Professor, Department of Anesthesia, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, 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