{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:03:44Z","timestamp":1784901824703,"version":"3.55.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,1]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Although intravenous patient-controlled analgesia opioids and epidural analgesia offer improved analgesia for postoperative patients treated on an acute pain service, these modalities also expose patients to some risk of serious morbidity and even mortality. Root cause analysis, a process for identifying the causal factor(s) that underlie an adverse event, has the potential to identify and address system issues and thereby decrease the chance of recurrence of these complications.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This study was designed to compare the incidence of adverse events on an acute pain service in three hospitals, before and after the introduction of a formal root cause analysis process. The \u201cbefore\u201d cohort included all patients with pain from February 2002 to July 2007. The \u201cafter\u201d cohort included all patients with pain from January 2009 to December 2009.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 35,384 patients were tracked over the 7 yr of this study. The after cohort showed significant reductions in the overall event rate (1.47\n vs.<\/jats:italic>\n 2.35% or 1 in 68\n vs.<\/jats:italic>\n 1 in 42, the rate of respiratory depression (0.41\n vs.<\/jats:italic>\n 0.71%), the rate of severe hypotension (0.78\n vs.<\/jats:italic>\n 1.34%), and the rate of patient-controlled analgesia pump programming errors (0.0\n vs.<\/jats:italic>\n 0.08%). Associated with these results, the incidence of severe pain increased from 6.5 to 10.5%. To achieve these results, 26 unique recommendations were made of which 23 being completed, 1 in progress, and 2 not completed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Formal root cause analysis was associated with an improvement in the safety of patients on a pain service. The process was effective in giving credibility to recommendations, but addressing all the action plans proved difficult with available resources.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/aln.0b013e3182a76f59","type":"journal-article","created":{"date-parts":[[2013,12,18]],"date-time":"2013-12-18T10:17:45Z","timestamp":1387361865000},"page":"97-109","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":27,"title":["Hamilton Acute Pain Service Safety Study"],"prefix":"10.1097","volume":"120","author":[{"given":"James E.","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"McLean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Antoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Musson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Kampf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Buckley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Marcoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Frketich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lehana","family":"Thabane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20241223","first-page":"100","article-title":"Development of an anesthesiology-based postoperative pain management service.","volume":"68","year":"1988","journal-title":"A"},{"key":"R2-20241223","first-page":"1","article-title":"Advances in pain.","volume":"87","year":"2001","journal-title":"Br J Anaesth"},{"key":"R3-20241223","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0304-3959(93)90016-I","article-title":"Safety assessment of postoperative pain management by an acute pain service.","volume":"55","year":"1993","journal-title":"Pain"},{"key":"R4-20241223","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jclinane.2005.01.006","article-title":"The frequency and timing of respiratory depression in 1524 postoperative patients treated with systemic or neuraxial morphine.","volume":"17","year":"2005","journal-title":"J Clin Anesth"},{"key":"R5-20241223","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0885-3924(97)00182-6","article-title":"The safety and utilization of patient-controlled analgesia.","volume":"14","year":"1997","journal-title":"J Pain Symptom Manage"},{"key":"R6-20241223","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1034\/j.1399-6576.2001.045007795.x","article-title":"Efficacy and safety of patient-controlled opioid analgesia for acute postoperative pain. A quantitative systematic review.","volume":"45","year":"2001","journal-title":"Acta Anaesthesiol Scand"},{"key":"R7-20241223","first-page":"531","article-title":"The Veterans Affairs root cause analysis system in action.","volume":"28","year":"2002","journal-title":"Jt Comm J Qual Improv"},{"key":"R8-20241223","first-page":"1427","article-title":"Impact of a comprehensive safety initiative on patient-controlled analgesia errors.","volume":"113","year":"2010","journal-title":"A"},{"key":"R9-20241223","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1126\/science.183.4128.922","article-title":"What Happened at Hawthorne?: New evidence suggests the Hawthorne effect resulted from operant reinforcement contingencies.","volume":"183","year":"1974","journal-title":"Science"},{"key":"R10-20241223","first-page":"18","article-title":"Predictors of cognitive dysfunction after major noncardiac surgery.","volume":"108","year":"2008","journal-title":"A"},{"key":"R11-20241223","first-page":"21","article-title":"Using aggregate root cause analysis to reduce falls.","volume":"31","year":"2005","journal-title":"Jt Comm J Qual Patient Saf"},{"key":"R12-20241223","first-page":"391","article-title":"The effectiveness of root cause analysis: What does the literature tell us?","volume":"34","year":"2008","journal-title":"Jt Comm J Qual Patient Saf"}],"container-title":["Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.asahq.org\/anesthesiology\/article-pdf\/120\/1\/97\/264438\/20140100_0-00025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/anesthesiology.pubs.asahq.org\/article.aspx?volume=120&page=97","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:17:29Z","timestamp":1784899049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1097\/ALN.0b013e3182a76f59"}},"subtitle":["Using Root Cause Analysis to Reduce the Incidence of Adverse Events"],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.1097\/aln.0b013e3182a76f59","relation":{},"ISSN":["0003-3022"],"issn-type":[{"value":"0003-3022","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}