{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:49:39Z","timestamp":1791755379076,"version":"4.3.4"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1097\/ana.0b013e31826318af","type":"journal-article","created":{"date-parts":[[2012,7,21]],"date-time":"2012-07-21T09:48:59Z","timestamp":1342864139000},"page":"16-24","source":"Crossref","is-referenced-by-count":109,"title":["The Effect of Intraoperative Infusion of Dexmedetomidine on the Quality of Recovery After Major Spinal Surgery"],"prefix":"10.1097","volume":"25","author":[{"given":"Alex","family":"Bekker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Haile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorosch","family":"Didehvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Babu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Martiniuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20210126","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/01.aco.0000236143.61593.14","article-title":"Anesthesia drugs, immunity, and long-term outcome.","volume":"19","author":"Homburger","year":"2006","journal-title":"Curr Opin Anaesthesiol"},{"key":"R2-3-20210126","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00540-008-0626-2","article-title":"Anesthetics, immune cells, and immune responses.","volume":"22","author":"Kurosawa","year":"2008","journal-title":"J Anesth"},{"key":"R3-3-20210126","first-page":"205","article-title":"Neuroendocrine and inflammatory aspects of surgery: do they affect outcome Acta Anaesthesiol Belg.","volume":"50","author":"Kennedy","year":"1999","journal-title":""},{"key":"R4-3-20210126","first-page":"667","article-title":"Is there a relationship between cognitive dysfunction and systemic inflammatory response after cardiopulmonary bypass Ann Thorac Surg.","volume":"71","author":"Westaby","year":"2001","journal-title":""},{"key":"R5-3-20210126","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/SLA.0b013e318211d7b5","article-title":"Improving postoperative immune status and resistance to cancer metastasis: a combined perioperative approach of immunostimulation and prevention of excessive surgical stress responses.","volume":"253","author":"Goldfarb","year":"2011","journal-title":"Ann Surg"},{"key":"R6-3-20210126","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.jclinane.2008.10.010","article-title":"Results of a pilot study on the effects of propofol and dexmedetomidine on inflammatory responses and intraabdominal pressure in severe sepsis.","volume":"21","author":"Tasdogan","year":"2009","journal-title":"J Clin Anesth"},{"key":"R7-3-20210126","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1097\/01.CCM.0000128579.84228.2A","article-title":"Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats.","volume":"32","author":"Taniguchi","year":"2004","journal-title":"Crit Care Med"},{"key":"R8-3-20210126","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00000539-200101000-00062","article-title":"Measuring health status (quality of recovery) after anesthesia and surgery.","volume":"92","author":"Myles","year":"2001","journal-title":"Anesth Analg"},{"key":"R9-3-20210126","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/oxfordjournals.bja.a013366","article-title":"Validity and reliability of a postoperative quality of recovery score: the QoR-40.","volume":"84","author":"Myles","year":"2000","journal-title":"Br J Anaesth"},{"key":"R10-3-20210126","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1477-7525-5-12","article-title":"Assessment of fatigue in chronic disease: a bibliographic study of fatigue measurement scales.","volume":"5","author":"Hjollund","year":"2007","journal-title":"Health Qual Life Outcomes"},{"key":"R11-3-20210126","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1093\/sleep\/31.11.1601","article-title":"Validation of the fatigue severity scale in a Swiss cohort.","volume":"31","author":"Valko","year":"2008","journal-title":"Sleep"},{"key":"R12-3-20210126","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1097\/00000542-200311000-00024","article-title":"Quality of recovery from anesthesia in neurosurgical patients.","volume":"99","author":"Leslie","year":"2003","journal-title":"Anesthesiology"},{"key":"R13-3-20210126","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/bja\/aer505","article-title":"Simplified postoperative nausea and vomiting impact scale for audit and post-discharge review.","volume":"108","author":"Myles","year":"2012","journal-title":"Br J Anaesth"},{"key":"R14-3-20210126","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1471-2172-8-27","article-title":"A guide to modern statistical analysis of immunological data.","volume":"8","author":"Genser","year":"2007","journal-title":"BMC Immunol"},{"key":"R15-3-20210126","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/01.ccx.0000235210.85073.fc","article-title":"The inflammatory response to surgery and trauma.","volume":"12","author":"Kohl","year":"2006","journal-title":"Curr Opin Crit Care"},{"key":"R16-3-20210126","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1007\/BF01658930","article-title":"Postoperative fatigue.","volume":"17","author":"Christensen","year":"1993","journal-title":"World J Surg"},{"key":"R17-3-20210126","first-page":"326","article-title":"Postoperative inflammatory reaction and atrial fibrillation: simple correlation or causation Ann Thorac Surg.","volume":"88","author":"Anselmi","year":"2009","journal-title":""},{"key":"R18-3-20210126","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1111\/j.1532-5415.2008.01851.x","article-title":"Time-course of cytokines during delirium in elderly patients with hip fractures.","volume":"56","author":"van Munster","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"R19-3-20210126","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0140-6736(03)14966-5","article-title":"Anaesthesia, surgery, and challenges in postoperative recovery.","volume":"362","author":"Kehlet","year":"2003","journal-title":"Lancet"},{"key":"R20-3-20210126","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/ANA.0b013e318232deaa","article-title":"2 adrenergic-mediated reduction of blood glutamate levels and improved neurological outcome after traumatic brain injury in rats.","volume":"24","author":"Zlotnik","year":"2012","journal-title":"J Neurosurg Anesthesiol"},{"key":"R21-3-20210126","first-page":"47","article-title":"Labat lecture 2005: surgical stress and postoperative outcome-from here to where Reg Anesth Pain Med.","volume":"31","author":"Kehlet","year":"2006","journal-title":""},{"key":"R22-3-20210126","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/ALN.0b013e31822a24c2","article-title":"Perioperative single dose systemic dexamethasone for postoperative pain: a meta-analysis of randomized controlled trials.","volume":"115","author":"De Oliveira","year":"2011","journal-title":"Anesthesiology"},{"key":"R23-3-20210126","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/bja\/aen015","article-title":"Infusion of hypertonic saline before elective hysterectomy: effects on cytokines and stress hormones.","volume":"100","author":"Kolsen-Petersen","year":"2008","journal-title":"Br J Anaesth"},{"key":"R24-3-20210126","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.coph.2009.08.007","article-title":"Stress hormones: physiological stress and regulation of metabolism.","volume":"9","author":"Kyrou","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"R25-3-20210126","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00423-011-0790-y","article-title":"Fast-track surgery-an update on physiological care principles to enhance recovery.","volume":"396","author":"Kehlet","year":"2011","journal-title":"Langenbecks Arch Surg"},{"key":"R26-3-20210126","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.pneurobio.2010.08.006","article-title":"Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors.","volume":"92","author":"Borsook","year":"2010","journal-title":"Prog Neurobiol"},{"key":"R27-3-20210126","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1213\/01.ANE.0000132974.32249.C8","article-title":"Preincisional intravenous pentoxifylline attenuating perioperative cytokine response, reducing morphine consumption, and improving recovery of bowel function in patients undergoing colorectal cancer surgery.","volume":"99","author":"Lu","year":"2004","journal-title":"Anesth Analg"},{"key":"R28-3-20210126","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/ALN.0b013e318214b9de","article-title":"Effects of volatile and intravenous anesthesia on the alveolar and systemic inflammatory response in thoracic surgical patients.","volume":"115","author":"Schilling","year":"2011","journal-title":"Anesthesiology"},{"key":"R29-3-20210126","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1097\/00000539-200006000-00035","article-title":"The effect of clonidine pretreatment on the perioperative proinflammatory cytokines, cortisol, and ACTH responses in patients undergoing total abdominal hysterectomy.","volume":"90","author":"Kim","year":"2000","journal-title":"Anesth Analg"},{"key":"R30-3-20210126","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neubiorev.2008.10.005","article-title":"Evidence for a cytokine model of cognitive function.","volume":"33","author":"McAfoose","year":"2009","journal-title":"Neurosci Biobehav Rev"},{"key":"R31-3-20210126","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain.","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"R32-3-20210126","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1097\/00000658-199608000-00010","article-title":"Cytokine and hormonal changes after cholecystectomy. Effect of ibuprofen pretreatment.","volume":"224","author":"Chambrier","year":"1996","journal-title":"Ann Surg"},{"key":"R33-3-20210126","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1213\/01.ANE.0000117146.46373.51","article-title":"The effect of epidural clonidine on perioperative cytokine response, postoperative pain, and bowel function in patients undergoing colorectal surgery.","volume":"99","author":"Wu","year":"2004","journal-title":"Anesth Analg"},{"key":"R34-3-20210126","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1213\/00000539-200108000-00026","article-title":"Clonidine suppresses plasma and cerebrospinal fluid concentrations of TNF-alpha during the perioperative period.","volume":"93","author":"Nader","year":"2001","journal-title":"Anesth Analg"},{"key":"R35-3-20210126","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jclinane.2004.12.017","article-title":"Effect of 2 anesthetic techniques on the postoperative proinflammatory and anti-inflammatory cytokine response and cellular immune function to minor surgery.","volume":"17","author":"Schneemilch","year":"2005","journal-title":"J Clin Anesth"},{"key":"R36-3-20210126","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00423-002-0346-2","article-title":"Different immune responses to abdominal surgery in men and women.","volume":"387","author":"Wichmann","year":"2003","journal-title":"Langenbecks Arch Surg"}],"container-title":["Journal of Neurosurgical Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00008506-201301000-00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T01:27:30Z","timestamp":1618018050000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00008506-201301000-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1097\/ana.0b013e31826318af","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717971087.793469560","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717971087.793471211","asserted-by":"object"}]},"ISSN":["0898-4921"],"issn-type":[{"value":"0898-4921","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}