{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T17:29:23Z","timestamp":1794590963759,"version":"4.9.1"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Genetic technology has advanced dramatically in the past few decades, and its applications and use in caring for and counseling pregnant women has been transformational in the realm of prenatal diagnosis. Two of the newer genetic technologies in the prenatal setting are chromosomal microarray and whole-exome sequencing. Chromosomal microarray analysis is a method of measuring gains and losses of DNA throughout the human genome. It can identify chromosomal aneuploidy and other large changes in the structure of chromosomes as well as submicroscopic abnormalities that are too small to be detected by traditional modalities. Prenatal chromosomal microarray analysis is recommended for a patient with a fetus with one or more major structural abnormalities identified on ultrasonographic examination and who is undergoing invasive prenatal diagnosis. Whole-genome sequencing analyzes the entire genome, including noncoding regions (introns) and coding regions (exons). However, because the introns are typically of little clinical relevance, there has been a focus instead on whole-exome sequencing, which examines the coding regions (exons) of the genome. The exons generally have greater clinical relevance and applicability to patient care. However, the routine use of whole-genome or whole-exome sequencing for prenatal diagnosis is not recommended outside of the context of clinical trials.<\/jats:p>","DOI":"10.1097\/aog.0000000000001817","type":"journal-article","created":{"date-parts":[[2016,11,23]],"date-time":"2016-11-23T10:10:28Z","timestamp":1479895828000},"page":"e262-e268","source":"Crossref","is-referenced-by-count":268,"title":["Committee Opinion No.682: Microarrays and Next-Generation Sequencing Technology: The Use of Advanced Genetic Diagnostic Tools in Obstetrics and Gynecology"],"prefix":"10.1097","volume":"128","member":"276","reference":[{"key":"R1-20230711","first-page":"e108","article-title":"Practice Bulletin No. 162. 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Working Group of the American College of Medical Genetics Laboratory Quality Assurance Committee","volume":"13","author":"Kearney","year":"2011","journal-title":"Genet Med"},{"key":"R3-20230711","doi-asserted-by":"crossref","first-page":"R215","DOI":"10.1093\/hmg\/ddi268","article-title":"Identification of disease genes by whole genome CGH arrays","volume":"14","author":"Vissers","year":"2005","journal-title":"Hum Mol Genet"},{"key":"R4-20230711","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1056\/NEJMoa1201569","article-title":"Karyotype versus microarray testing for genetic abnormalities after stillbirth. NICHD Stillbirth Collaborative Research Network","volume":"367","author":"Reddy","year":"2012","journal-title":"N Engl J Med"},{"key":"R5-20230711","article-title":"Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits, and challenges","author":"Sahoo","year":"2016","journal-title":"Genet Med"},{"key":"R6-20230711","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1056\/NEJMoa1203382","article-title":"Chromosomal microarray versus karyotyping for prenatal diagnosis","volume":"367","author":"Wapner","year":"2012","journal-title":"N Engl J Med"},{"key":"R7-20230711","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/pd.3943","article-title":"Detection rates of clinically significant genomic alterations by microarray analysis for specific anomalies detected by ultrasound","volume":"32","author":"Shaffer","year":"2012","journal-title":"Prenat Diagn"},{"key":"R8-20230711","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/gim.2013.168","article-title":"A prospective study of the clinical utility of prenatal chromosomal microarray analysis in fetuses with ultrasound abnormalities and an exploration of a framework for reporting unclassified variants and risk factors","volume":"16","author":"Brady","year":"2014","journal-title":"Genet Med"},{"key":"R9-20230711","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/gim.2012.113","article-title":"Women\u2019s experiences receiving abnormal prenatal chromosomal microarray testing results","volume":"15","author":"Bernhardt","year":"2013","journal-title":"Genet Med"},{"key":"R10-20230711","doi-asserted-by":"crossref","first-page":"713","DOI":"10.3390\/jcm3030713","article-title":"The psychological challenges of replacing conventional karyotyping with genomic SNP array analysis in prenatal testing","volume":"3","author":"Riedijk","year":"2014","journal-title":"J Clin Med"},{"key":"R11-20230711","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/gim.2012.83","article-title":"Variability in laboratory reporting practices for regions of homozygosity indicating parental relatedness as identified by SNP microarray testing","volume":"14","author":"Grote","year":"2012","journal-title":"Genet Med"},{"key":"R12-20230711","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1056\/NEJMoa1306555","article-title":"Clinical whole-exome sequencing for the diagnosis of mendelian disorders","volume":"369","author":"Yang","year":"2013","journal-title":"N Engl J Med"},{"issue":"1","key":"R13-20230711","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2040-2392-5-1","article-title":"Exome sequencing of extended families with autism reveals genes shared across neurodevelopmental and neuropsychiatric disorders","volume":"5","author":"Cukier","year":"2014","journal-title":"Mol Autism"},{"key":"R14-20230711","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/pd.4675","article-title":"Exome sequencing for prenatal diagnosis of fetuses with sonographic abnormalities","volume":"35","author":"Drury","year":"2015","journal-title":"Prenat Diagn"},{"key":"R15-20230711","first-page":"759","article-title":"ACMG Board of Directors","volume":"14","year":"2012","journal-title":"Genet Med"},{"key":"R16-20230711","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/gim.2013.73","article-title":"ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. American College of Medical Genetics and Genomics","volume":"15","author":"Green","year":"2013","journal-title":"Genet Med"},{"key":"R17-20230711","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/gim.2014.10","article-title":"Clinical whole-exome sequencing: are we there yet?","volume":"16","author":"Atwal","year":"2014","journal-title":"Genet Med"},{"key":"R18-20230711","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ajog.2016.02.030","article-title":"Clinical validation of a noninvasive prenatal test for genomewide detection of fetal copy number variants","volume":"215","author":"Lefkowitz","year":"2016","journal-title":"Am J Obstet Gynecol"}],"container-title":["Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00006250-201612000-00055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T15:25:56Z","timestamp":1689089156000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006250-201612000-00055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1097\/aog.0000000000001817","relation":{},"ISSN":["0029-7844"],"issn-type":[{"value":"0029-7844","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}