{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T10:35:28Z","timestamp":1782902128679,"version":"3.54.5"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:sec><jats:title>BACKGROUND:<\/jats:title><jats:p>Fetal tachycardia is attributable to a variety of etiologies, including an untreated maternal medical condition or an indicator of potential fetal compromise. Maternal medication administration may also affect the fetal heart rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>CASE:<\/jats:title><jats:p>A 28-year-old nulliparous patient at 41 weeks of gestation was treated for pruritus with intravenous diphenhydramine after epidural administration of fentanyl. Within 14 minutes, the fetal heart rate increased from a baseline of 155 beats per minute (bpm) to more than 200 bpm while maintaining moderate variability. This was accompanied by an increase in uterine contractions occurring every 1.5 minutes. The fetal tachycardia lasted 51 minutes; several hours later, a healthy neonate was delivered.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION:<\/jats:title><jats:p>Diphenhydramine may produce transient fetal tachycardia as well as increased maternal uterine activity.<\/jats:p><\/jats:sec>","DOI":"10.1097\/aog.0000000000002147","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T14:41:44Z","timestamp":1499784104000},"page":"374-376","source":"Crossref","is-referenced-by-count":6,"title":["Transient Fetal Tachycardia After Intravenous Diphenhydramine Administration"],"prefix":"10.1097","volume":"130","author":[{"given":"Alice","family":"Abernathy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Alsina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Greer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Egerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230711","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0022-3565(25)20017-9","article-title":"Effects of diphenhydramine in the fetal lamb after maternal or fetal administration","volume":"247","author":"Rurak","year":"1988","journal-title":"J Pharmacol Exp Ther"},{"key":"R2-20230711","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1203\/00006450-198611000-00013","article-title":"Adaptation of fetal pulmonary blood flow to local infusion of tolazoline","volume":"20","author":"Abman","year":"1986","journal-title":"Pediatr Res"},{"issue":"suppl","key":"R3-20230711","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/00006250-198409001-00004","article-title":"Fetal distress during a maternal systemic allergic reaction","volume":"64","author":"Klein","year":"1984","journal-title":"Obstet Gynecol"},{"key":"R4-20230711","first-page":"606","article-title":"Immediate effects of dimenhydrinate on uterine contraction and the fetal cardiac rhythm during labor [in French]","volume":"127","author":"Lemay","year":"1982","journal-title":"Can Med Assoc J"},{"key":"R5-20230711","first-page":"453","article-title":"Effect of dimehydrinate on the fetal heart rate and uterine contractions [in Spanish]","volume":"41","author":"Sosa","year":"1977","journal-title":"Ginecol Obstet Mex"},{"key":"R6-20230711","first-page":"195","article-title":"Fetal and neonatal cardiopulmonary response to histamine","volume":"48","author":"Woods","year":"1976","journal-title":"Obstet Gynecol"},{"key":"R7-20230711","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1399-0004.1973.tb01144.x","article-title":"Triploidy 69, XXX in a stillborn girl","volume":"4","author":"Halbrecht","year":"1973","journal-title":"Clin Genet"},{"key":"R8-20230711","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0002-9378(96)70059-5","article-title":"Diphenhydramine overdose during pregnancy: lessons from the past","volume":"175","author":"Brost","year":"1996","journal-title":"Am J Obstet Gynecol"}],"container-title":["Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00006250-201708000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T22:24:20Z","timestamp":1750544660000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006250-201708000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1097\/aog.0000000000002147","relation":{},"ISSN":["0029-7844"],"issn-type":[{"value":"0029-7844","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]}}}