{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:29:28Z","timestamp":1783556968083,"version":"3.55.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n            <jats:title>ABSTRACT:<\/jats:title>\n            <jats:p>M\u00fcllerian agenesis, also referred to as m\u00fcllerian aplasia, Mayer-Rokitansky-K\u00fcster-Hauser syndrome, or vaginal agenesis, has an incidence of 1 per 4,500\u20135,000 females. M\u00fcllerian agenesis is cau0073ed by embryologic underdevelopment of the m\u00fcllerian duct, with resultant agenesis or atresia of the vagina, uterus, or both. Patients with m\u00fcllerian agenesis usually are identified when they are evaluated for primary amenorrhea with otherwise typical growth and pubertal development. The most important steps in the effective management of m\u00fcllerian agenesis are correct diagnosis of the underlying condition, evaluation for associated congenital anomalies, and psychosocial counseling in addition to treatment or intervention to address the functional effects of genital anomalies. The psychologic effect of the diagnosis of m\u00fcllerian agenesis should not be underestimated. All patients with m\u00fcllerian agenesis should be offered counseling and encouraged to connect with peer support groups. Future options for having children should be addressed with patients: options include adoption and gestational surrogacy. Assisted reproductive techniques with use of a gestational carrier (surrogate) have been shown to be successful for women with m\u00fcllerian agenesis. Nonsurgical vaginal elongation by dilation should be the first-line approach. When well-counseled and emotionally prepared, almost all patients (90\u201396%) will be able to achieve anatomic and functional success by primary vaginal dilation. In cases in which surgical intervention is required, referrals to centers with expertise in this area should be considered because few surgeons have extensive experience in construction of the neovagina and surgery by a trained surgeon offers the best opportunity for a successful result.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/aog.0000000000002452","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T14:06:26Z","timestamp":1514037986000},"page":"196-197","source":"Crossref","is-referenced-by-count":19,"title":["ACOG Committee Opinion No. 728 Summary: M\u00fcllerian Agenesis: Diagnosis, Management, And Treatment"],"prefix":"10.1097","volume":"131","member":"276","container-title":["Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00006250-201801000-00035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T18:13:14Z","timestamp":1689099194000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006250-201801000-00035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/aog.0000000000002452","relation":{},"ISSN":["0029-7844"],"issn-type":[{"value":"0029-7844","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]}}}