{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:34:48Z","timestamp":1793082888903,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To estimate whether prophylactic antibiotics at the time of repair of third- or fourth-degree perineal tears after vaginal delivery prevent wound infection and breakdown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This was a prospective, randomized, placebo-controlled study. Patients who sustained third- or fourth-degree perineal tears after a vaginal delivery were recruited for the study. Each patient was given a single intravenous dose of a second-generation cephalosporin (cefotetan or cefoxitin) or placebo before repair of third- or fourth-degree perineal tears. Obstetricians and patients were blinded to study drug. The perineum was inspected for evidence of infection or breakdown at discharge from the hospital and at 2 weeks postpartum. Primary end points were gross disruption or purulent discharge at site of perineal repair by 2 weeks postpartum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      One hundred forty-seven patients were recruited for the study. Of these, 83 patients received placebo and 64 patients received antibiotics. Forty patients (27.2%) did not return for their 2-week appointment. Of the patients seen at 2 weeks postpartum, 4 of 49 (8.2%) patients who received antibiotics and 14 of 58 (24.1%) patients who received placebo developed a perineal wound complication (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =.037). There were no differences between groups in parity, incidence of diabetes, operative delivery, or third-degree compared with fourth-degree lacerations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>By 2 weeks postpartum, patients who received prophylactic antibiotics at the time of third- or fourth-degree laceration repair had a lower rate of perineal wound complications than patients who received placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL TRIAL REGISTRATION:<\/jats:title>\n                    <jats:p>ClinicalTrials.gov, www.clincaltrials.gov, NCT00186082<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LEVEL OF EVIDENCE:<\/jats:title>\n                    <jats:p>I<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/aog.0b013e31816de8ad","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T07:44:06Z","timestamp":1291103046000},"page":"1268-1273","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":102,"title":["Antibiotic Prophylaxis for Prevention of Postpartum Perineal Wound Complications"],"prefix":"10.1097","volume":"111","author":[{"given":"Neena","family":"Duggal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celia","family":"Mercado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Daniels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Bujor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron B.","family":"Caughey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser Y.","family":"El-Sayed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20261027","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/01.AOG.0000242616.56617.ff","article-title":"Risk factors for anal sphincter tear during vaginal delivery.","volume":"109","author":"Fitzgerald","year":"2007","journal-title":"Obstet Gynecol"},{"key":"R2-4-20261027","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1067\/mob.2000.105403","article-title":"Severe perineal lacerations during vaginal delivery: the University of Miami experience.","volume":"182","author":"Angioli","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"R4-4-20261027","first-page":"225","article-title":"Obstetric anal sphincter lacerations.","volume":"98","author":"Handa","year":"2001","journal-title":"Obstet Gynecol"},{"key":"R5-4-20261027","first-page":"218","article-title":"Incidence of third-degree perineal tears in labour and outcome after primary repair.","volume":"83","author":"Walsh","year":"1996","journal-title":"Br J Surg"},{"key":"R6-4-20261027","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1471-0528.2000.tb11093.x","article-title":"Anal sphincter tears: prospective study of obstetric risk factors.","volume":"107","author":"Samuelsson","year":"2000","journal-title":"BJOG"},{"key":"R7-4-20261027","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9378(97)70507-6","article-title":"Is there a benefit to episiotomy at operative vaginal delivery? 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