{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:23:45Z","timestamp":1787318625071,"version":"build-2736575974"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1097\/aog.0b013e31817d0262","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T07:35:37Z","timestamp":1291102537000},"page":"127-134","source":"Crossref","is-referenced-by-count":110,"title":["Progesterone for the Prevention of Preterm Birth"],"prefix":"10.1097","volume":"112","author":[{"given":"Jodie M.","family":"Dodd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicki J.","family":"Flenady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Cincotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline A.","family":"Crowther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-22-20210801","first-page":"247","article-title":"Recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths. Modifications recommended by FIGO October 14 1976.","volume":"56","year":"1977","journal-title":"Acta Obstet Gynecol Scand"},{"key":"R2-22-20210801","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/01.AOG.0000130837.57743.7b","article-title":"Heterogeneity of perinatal outcomes in the preterm delivery syndrome.","volume":"104","author":"Villar","year":"2004","journal-title":"Obstet Gynecol"},{"issue":"suppl 1","key":"R3-22-20210801","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-0528.2005.00575.x","article-title":"The epidemiology of preterm labour.","volume":"112","author":"Steer","year":"2005","journal-title":"BJOG"},{"key":"R4-22-20210801","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.siny.2004.04.002","article-title":"Epidemiology of preterm birth and neonatal outcome.","volume":"9","author":"Wen","year":"2004","journal-title":"Semin Fetal Neonatal Med"},{"key":"R5-22-20210801","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1111\/j.1471-0528.2006.00923.x","article-title":"Preterm birth and multiple pregnancy in European countries participating in the PERISTAT project.","volume":"113","author":"Blondel","year":"2006","journal-title":"BJOG"},{"key":"R8-22-20210801","first-page":"1","article-title":"Births: preliminary data for 2005.","volume":"55","author":"Hamilton","year":"2006","journal-title":"Natl Vital Stat Rep"},{"key":"R9-22-20210801","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1001\/jama.296.24.2907","article-title":"Groups take aim at US preterm birth rate.","volume":"296","author":"Kuehn","year":"2006","journal-title":"JAMA"},{"key":"R10-22-20210801","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1136\/bmj.38751.524132.2F","article-title":"Spontaneous preterm delivery in primiparous women at low risk in Denmark: population based study.","volume":"332","author":"Langhoff-Roos","year":"2006","journal-title":"BMJ"},{"key":"R11-22-20210801","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1471-0528.2007.01323.x","article-title":"Spontaneous preterm birth of liveborn infants in women at low risk in Australia over 10 years: a population-based study.","volume":"114","author":"Tracy","year":"2007","journal-title":"BJOG"},{"key":"R12-22-20210801","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/0140-6736(90)93247-M","article-title":"European community collaborative study of outcome of pregnancy between 22 and 28 weeks gestation. Working group on the very low birthweight infant.","volume":"336","year":"1990","journal-title":"Lancet"},{"key":"R13-22-20210801","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1067\/mob.2001.115280","article-title":"Survival, morbidity, and resource use of infants of 25 weeks gestational age or less.","volume":"185","author":"Chan","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"R14-22-20210801","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1001\/jama.284.7.843","article-title":"The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System.","volume":"284","author":"Kramer","year":"2000","journal-title":"JAMA"},{"key":"R15-22-20210801","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0002-9378(96)70309-5","article-title":"Neonatal survival and disability rate at age 18 months for infants born between 23 and 28 weeks of gestation.","volume":"174","author":"Lefebvre","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"R16-22-20210801","article-title":"The report of the Australian and New Zealand Neonatal Network, 2000.","author":"Donoghue","year":"2002"},{"key":"R17-22-20210801","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1365-3016.1992.tb00769.x","article-title":"Survival and cerebral palsy in low birthweight infants: implications for perinatal care.","volume":"6","author":"Stanley","year":"1992","journal-title":"Paediatr Perinat Epidemiol"},{"key":"R18-22-20210801","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1001\/jama.283.12.1591","article-title":"Rates and factors associated with recurrence of preterm delivery.","volume":"283","author":"Adams","year":"2000","journal-title":"JAMA"},{"key":"R19-22-20210801","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/0002-9378(79)90742-7","article-title":"The tendency to repeat gestational age and birth weight in successive births.","volume":"135","author":"Bakketeig","year":"1979","journal-title":"Am J Obstet Gynecol"},{"key":"R20-22-20210801","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/oxfordjournals.epirev.a036128","article-title":"Epidemiology of preterm birth.","volume":"15","author":"Berkowitz","year":"1993","journal-title":"Epidemiol Rev"},{"key":"R21-22-20210801","first-page":"379","article-title":"Recurrence of preterm birth in singleton and twin pregnancies.","volume":"98","author":"Bloom","year":"2001","journal-title":"Obstet Gynecol"},{"key":"R22-22-20210801","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0002-9378(97)70570-2","article-title":"Inhibition and augmentation of progesterone production during pregnancy: effects on parturition in rhesus monkeys.","volume":"176","author":"Haluska","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"R23-22-20210801","first-page":"608","article-title":"Actions of placental and fetal adrenal steroid hormones in primate pregnancy.","volume":"16","author":"Pepe","year":"1995","journal-title":"Endocrine Rev"},{"key":"R24-22-20210801","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/molehr\/7.9.875","article-title":"Interactions between progesterone receptor isoforms in myometrial cells in human labour.","volume":"7","author":"Pieber","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"R25-22-20210801","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0301-2115(02)00422-0","article-title":"The involvement of progesterone in the onset of human labour.","volume":"108","author":"Astle","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R26-22-20210801","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/33176","article-title":"inhibition of oxytocin receptor function by direct binding of progesterone.","volume":"392","author":"Grazzini","year":"1998","journal-title":"Nature"},{"key":"R27-22-20210801","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1016\/S0140-6736(99)04149-5","article-title":"Improving the quality of reports of meta-analyses of randomised controlled trials: the QUOROM statement. Quality of Reporting of Meta-analyses.","volume":"354","author":"Moher","year":"1999","journal-title":"Lancet"},{"key":"R28-22-20210801","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1056\/NEJMoa070641","article-title":"A trial of 17 Alpha-hydroxyprogesterone caproate to prevent prematurity in twins.","volume":"357","author":"Rouse","year":"2007","journal-title":"N Engl J Med"},{"key":"R29-22-20210801","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1479-828X.2007.00803.x","article-title":"Progesterone for maintenance tocolytic therapy after threatened preterm labour: A randomised controlled trial.","volume":"48","author":"Borna","year":"2008","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"R30-22-20210801","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1067\/mob.2003.41","article-title":"Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study.","volume":"188","author":"da Fonseca","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"R31-22-20210801","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1056\/NEJMoa067815","article-title":"Progesterone and the risk of preterm birth among women with a short cervix.","volume":"357","author":"Fonesca","year":"2007","journal-title":"N Engl J Med"},{"key":"R32-22-20210801","first-page":"692","article-title":"Inefficacy of 17 alpha hydroxyprogesterone caproate in the prevention of prematurity in twin pregnancy.","volume":"56","author":"Hartikainen-Sorri","year":"1980","journal-title":"Obstet Gynecol"},{"key":"R33-22-20210801","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0002-9378(83)91051-7","article-title":"The effect of 17 alpha hydroxyprogesterone caproate on pregnancy outcome in an active-duty military population.","volume":"146","author":"Hauth","year":"1983","journal-title":"Am J Obstet Gynecol"},{"key":"R34-22-20210801","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1056\/NEJM197510022931401","article-title":"Efficacy of 17 alpha hydroxyprogesterone caproate in the prevention of premature labor.","volume":"293","author":"Johnson","year":"1975","journal-title":"N Engl J Med"},{"key":"R35-22-20210801","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1056\/NEJMoa035140","article-title":"Prevention of recurrent preterm delivery by 17-alpha hydroxyprogesterone caproate [published erratum appears in N Engl J Med 2003;349:1299].","volume":"348","author":"Meis","year":"2003","journal-title":"N Engl J Med"},{"key":"R36-22-20210801","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/uog.5158","article-title":"Progesterone vaginal gel for the reduction of recurrent preterm birth: primary results from a randomized double blind placebo controlled trial.","volume":"30","author":"O'Brien","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"key":"R37-22-20210801","first-page":"65","article-title":"Etude en double aveugle d'un medicament prevenant la survenue prematuree de l'accouchement chez les femmes a risque eleve d'accouchement premature.","volume":"3","author":"Papiernik-Berkhauer","year":"1970","journal-title":"Edition Schering Serie IV"},{"key":"R38-22-20210801","doi-asserted-by":"crossref","first-page":"453e1","DOI":"10.1016\/j.ajog.2006.09.009","article-title":"Cervical length changes during preterm cervical ripening: effects of 17-alpha-hydroxyprogesterone caproate.","volume":"196","author":"Facchinetti","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"R39-22-20210801","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/01.AOG.0000281348.51499.bc","article-title":"Follow-up of children exposed in utero to 17 alpha-hydroxyprogesterone caproate compared with placebo.","volume":"110","author":"Northen","year":"2007","journal-title":"Obstet Gynecol"},{"key":"R40-22-20210801","first-page":"30","article-title":"Habitual abortion. A controlled clinical study of progestational therapy.","volume":"72","author":"LeVine","year":"1964","journal-title":"West J Surg"},{"key":"R41-22-20210801","first-page":"538","article-title":"Prevention of pre-term labour with progesterone.","volume":"69","author":"Suvonnakote","year":"1986","journal-title":"J Med Assoc Thai"},{"key":"R42-22-20210801","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0002-9378(85)90141-3","article-title":"Prevention of premature labor by 17alpha hydroxyprogesterone caproate.","volume":"151","author":"Yemini","year":"1985","journal-title":"Am J Obstet Gynecol"},{"key":"R43-22-20210801","first-page":"112","article-title":"West Los Angeles premature prevention program: significant impact.","volume":"15","author":"Hobel","year":"1987","journal-title":"J Perinat Med"},{"key":"R44-22-20210801","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/j.1879-3479.1979.tb00469.x","article-title":"A comparative study of the efficiency of hydroxyprogesterone caproate and of chlormadinone acetate in the prevention of premature labor.","volume":"16","author":"Br\u00e9art","year":"1979","journal-title":"Int J Gynecol Obstet"},{"key":"R45-22-20210801","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0002-9378(16)35945-2","article-title":"Effect of medroxyprogesterone acetate upon the duration and characteristics of human gestation and labor.","volume":"83","author":"Brenner","year":"1962","journal-title":"Am J Obstet Gynecol"},{"key":"R46-22-20210801","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0301-2115(01)00418-3","article-title":"A randomised trial of progesterone prophylaxis after midtrimester amniocentesis.","volume":"100","author":"Corrado","year":"2002","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R47-22-20210801","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/0002-9378(66)90173-6","article-title":"Prolonged gynecologic and endocrine manifestations subsequent to administration of medroxyprogesterone acetate during pregnancy.","volume":"95","author":"Turner","year":"1966","journal-title":"Am J Obstet Gynecol"},{"key":"R48-22-20210801","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/14767050500246243","article-title":"Oral dydrogesterone treatment during the first trimester of pregnancy: the prevention of miscarriage study. A double blind, prospectively randomised placebo controlled parallel group trial.","volume":"18","author":"Walch","year":"2005","journal-title":"J Matern Fetal Neonat Med"},{"issue":"suppl 1","key":"R49-22-20210801","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1016\/j.ajog.2006.10.375","article-title":"A randomized trial of cerclage versus 17 hydroxyprogesterone for the treatment of short cervix.","volume":"195","author":"Rust","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"R51-22-20210801","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1056\/NEJMe030081","article-title":"Progesterone and preterm delivery\u2014d\u00e9j\u00e0 vu all over again.","volume":"348","author":"Greene","year":"2003","journal-title":"N Engl J Med"},{"key":"R52-22-20210801","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1067\/mob.2003.194","article-title":"Supplemental progesterone to prevent preterm birth.","volume":"188","author":"Iams","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"R53-22-20210801","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/00006250-200311000-00050","article-title":"Use of progesteorne to reduce preterm birth. ACOG Committee Opinion No. 291.","volume":"102","year":"2003","journal-title":"Obstet Gynecol"}],"container-title":["Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006250-200807000-00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:44:05Z","timestamp":1786041845000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006250-200807000-00022"}},"subtitle":["A Systematic Review"],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/aog.0b013e31817d0262","relation":{},"ISSN":["0029-7844"],"issn-type":[{"value":"0029-7844","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}