{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T01:50:34Z","timestamp":1773712234791,"version":"3.50.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To estimate the association between spontaneous abortion and influenza vaccine receipt with a case-control study utilizing data from six health care organizations in the Vaccine Safety Datalink.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Women aged 18\u201344 years with spontaneous abortion during the autumn of 2005 or 2006 were identified using International Classification of Diseases, 9th Revision, Clinical Modification codes. Cases of spontaneous abortion at 5\u201316 weeks of gestation were confirmed by medical record review; date of fetal demise was based on ultrasound information when available. Control group individuals with a live birth were individually matched to case group individuals by health care organization and date of last menstrual period (LMP). The primary exposure of interest was influenza vaccination during the 28 days preceding the date of spontaneous abortion of the matched pair. Conditional logistic regression models adjusted for maternal age, health care utilization, maternal diabetes, and parity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Our final analysis included 243 women with spontaneous abortion and 243 matched control group women; 82% of women with spontaneous abortion had ultrasound confirmation of fetal demise. Using clinical diagnosis and ultrasound data, the mean gestational age at fetal demise was 7.8 weeks. Mean ages at LMP of case group women and control group women were 31.7 and 29.3 years, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;.001). Sixteen women with spontaneous abortion (7%) and 15 (6%) matched control group women received influenza vaccine within the 28-day exposure window. There was no association between spontaneous abortion and influenza vaccination in the 28-day exposure window (adjusted matched odds ratio 1.23, 95% confidence interval 0.53\u20132.89;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =.63).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>There was no statistically significant increase in the risk of pregnancy loss in the 4 weeks after seasonal inactivated influenza vaccination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LEVEL OF EVIDENCE:<\/jats:title>\n                    <jats:p>II<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/aog.0b013e318279f56f","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T14:40:27Z","timestamp":1444747227000},"page":"159-165","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":81,"title":["Trivalent Inactivated Influenza Vaccine and Spontaneous Abortion"],"prefix":"10.1097","volume":"121","author":[{"given":"Stephanie A.","family":"Irving","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burney A.","family":"Kieke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James G.","family":"Donahue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A.","family":"Mascola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Baggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"DeStefano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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Effectiveness of maternal influenza immunization in mothers and infants.","volume":"359","author":"Zaman","year":"2008","journal-title":"N Engl J Med"},{"key":"R14-24-20260317","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1001\/archpedi.160.12.1277","article-title":". Impact of maternal influenza vaccination during pregnancy on the incidence of acute respiratory illness visits among infants.","volume":"160","author":"France","year":"2006","journal-title":"Arch Pediatr Adolesc Med"},{"key":"R15-24-20260317","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.ajog.2004.12.019","article-title":". Safety of influenza vaccination during pregnancy.","volume":"192","author":"Munoz","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"R16-24-20260317","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/infdis\/140.2.141","article-title":"Immunization of pregnant women with influenza ANew Jersey76 virus vaccine: reactogenicity and immunogenicity in mother and infant.","volume":"140","author":"Sumaya","year":"1979","journal-title":"J Infect Dis"},{"key":"R17-24-20260317","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1001\/jama.2012.6131","article-title":". 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Vaccination against pandemic AH1N1 2009 influenza in pregnancy and risk of fetal death: cohort study in Denmark.","volume":"344","author":"Pasternak","year":"2012","journal-title":"BMJ"},{"key":"R26-24-20260317","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/0264-410X(94)90334-4","article-title":"An early humoral immune response in peripheral blood following parenteral inactivated influenza vaccination.","volume":"12","author":"Cox","year":"1994","journal-title":"Vaccine"},{"key":"R27-24-20260317","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1016\/j.vaccine.2010.02.088","article-title":". 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