{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:00:34Z","timestamp":1791442834947,"version":"4.3.3"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Adv Skin Wound Care"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>To estimate the total cost-per-wound healing response (CPR) and the per-day CPR of patients with chronic leg ulcers treated with pure hypochlorous acid (pHA) as part of their overall would healing regimen.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>The authors developed a deterministic decision-tree model to estimate the incremental CPR for pHA. The analysis was performed using clinical data from a published single-arm prospective study. The outcome of interest was re-epithelialization at 90 days. Economic data for pHA were based on public prices of pHA per dressing change from the wound care center perspective. The following time points were assessed: 90, 60, and 30 days. Dressing changes occurred every 2.5 days. Sensitivity analysis was performed to gauge the robustness of the results.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>A total of 31 patients (68% women) with 31 lesions (average age of wound, 29 months; range, 1-240 months) were included in the clinical study. Re-epithelialization occurred in 23 lesions (74%) at 90 days, 17 (55%) at 60 days, and 3 (10%) at 30 days. The total CPRs were $75.69, $68.27, and $193.44, and the per-day CPRs were $0.84, $1.13, and $6.45 at 90, 60, and 30 days, respectively. The sensitivity analysis revealed that CPRs ranged from $0.63 to $1.12 per day at 90 days.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSIONS<\/jats:title>\n            <jats:p>Incorporating pHA into standard wound healing protocols is a minimal added expense and may yield a substantial economic savings of $2,695 at 90 days.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/asw.0000000000000024","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T15:02:13Z","timestamp":1694185333000},"page":"587-590","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Cost-per-Response Analysis of Pure Hypochlorous Acid Among Patients with Chronic Venous Leg Ulcers: A Health Economic Analysis"],"prefix":"10.1097","volume":"36","author":[{"given":"Jeffrey A.","family":"Niezgoda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Niezgoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Niezgoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Mallow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"issue":"4","key":"bib1-20250615","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jvsv.2014.04.006","article-title":"The real cost of treating venous ulcers in contemporary vascular practice","volume":"2","year":"2014","journal-title":"J Vasc Surg Venous Lymphat Disord"},{"issue":"6","key":"bib2-20250615","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-4632.2004.02456.x","article-title":"Venous ulcer: epidemiology, physiopathology, diagnosis, and treatment","volume":"44","year":"2005","journal-title":"Int J Dermatol"},{"issue":"2","key":"bib3-20250615","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1089\/wound.2019.0946","article-title":"Human wounds and its burden: an updated compendium of estimates","volume":"8","year":"2019","journal-title":"Adv Wound Care"},{"key":"bib4-20250615","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2165\/00128071-200304080-00007","article-title":"The social and economic burden of venous leg ulcers: focus on the role of micronized purified flavonoid fraction adjuvant therapy","volume":"4","year":"2003","journal-title":"Am J Clin Dermatol"},{"key":"bib5-20250615","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jcot.2021.01.017","article-title":"The current burden of diabetic foot disease","volume":"17","year":"2021","journal-title":"J Clin Orth Trauma"},{"key":"bib6-20250615","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ajic.2014.01.012","article-title":"Surgical wound irrigation: a call for evidence-based standardization of practice","volume":"42","year":"2014","journal-title":"Am J Infect Control"},{"key":"bib7-20250615","first-page":"261","article-title":"The immediate and delayed post-debridement effects on tissue bacterial wound counts of hypochlorous acid versus saline irrigation in chronic wounds","volume":"16","year":"2016","journal-title":"ePlasty"},{"key":"bib8-20250615","first-page":"e5","article-title":"Hypochlorous acid as a potential wound care agent: part I. 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