{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:42:20Z","timestamp":1791830540020,"version":"4.3.4"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"\n Objectives:<\/jats:title>\n Understanding the association between sleep traits and tinnitus could help prevent and provide appropriate interventions against tinnitus. Therefore, this study aimed to assess the relationship between different sleep patterns and tinnitus.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n A cross-sectional analysis using baseline data (2006\u20132010, n = 168,064) by logistic regressions was conducted to evaluate the association between sleep traits (including the overall health sleep score and five sleep behaviors) and the occurrence (yes\/no), frequency (constant\/transient), and severity (upsetting\/not upsetting) of tinnitus. Further, a prospective analysis of participants without tinnitus at baseline (n = 9581) was performed, who had been followed-up for 7 years (2012\u20132019), to assess the association between new-onset tinnitus and sleep characteristics. Moreover, a subgroup analysis was also carried out to estimate the differences in sex by dividing the participants into male and female groups. A sensitivity analysis was also conducted by excluding ear-related diseases to avoid their confounding effects on tinnitus (n = 102,159).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In the cross-sectional analysis, participants with \u201ccurrent tinnitus\u201d (OR: 1.13, 95% CI: 1.04\u20131.22,\n p<\/jats:italic>\n = 0.004) had a higher risk of having a poor overall healthy sleep score and unhealthy sleep behaviors such as short sleep durations (OR: 1.09, 95% CI: 1.04\u20131.14,\n p<\/jats:italic>\n < 0.001), late chronotypes (OR: 1.09, 95% CI: 1.05\u20131.13,\n p<\/jats:italic>\n < 0.001), and sleeplessness (OR: 1.16, 95% CI: 1.11\u20131.22,\n p<\/jats:italic>\n < 0.001) than those participants who \u201cdid not have current tinnitus.\u201d However, this trend was not obvious between \u201cconstant tinnitus\u201d and \u201ctransient tinnitus.\u201d When considering the severity of tinnitus, the risk of \u201cupsetting tinnitus\u201d was obviously higher if participants had lower overall healthy sleep scores (OR: 1.31, 95% CI: 1.13\u20131.53,\n p<\/jats:italic>\n < 0.001). Additionally, short sleep duration (OR: 1.22, 95% CI: 1.12\u20131.33,\n p<\/jats:italic>\n < 0.001), late chronotypes (OR: 1.13, 95% CI: 1.04\u20131.22,\n p<\/jats:italic>\n = 0.003), and sleeplessness (OR: 1.43, 95% CI: 1.29\u20131.59,\n p<\/jats:italic>\n < 0.001) showed positive correlations with \u201cupsetting tinnitus.\u201d In the prospective analysis, sleeplessness presented a consistently significant association with \u201cupsetting tinnitus\u201d (RR: 2.28,\n p<\/jats:italic>\n = 0.001). Consistent results were observed in the sex subgroup analysis, where a much more pronounced trend was identified in females compared with the males. The results of the sensitivity analysis were consistent with those of the cross-sectional and prospective analyses.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Different types of sleep disturbance may be associated with the occurrence and severity of tinnitus; therefore, precise interventions for different types of sleep disturbance, particularly sleeplessness, may help in the prevention and treatment of tinnitus.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/aud.0000000000001273","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T09:01:38Z","timestamp":1664874098000},"page":"53-60","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["The Relationship Between Sleep Traits and Tinnitus in UK Biobank: A Population-Based Cohort Study"],"prefix":"10.1097","volume":"44","author":[{"given":"Jiajia","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danni","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendu","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Mu","sequence":"additional","affiliation":[{"name":"Langzhong People\u2019s Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Chengdu Second People\u2019s Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongchang","family":"Chen","sequence":"additional","affiliation":[{"name":"Chengdu Xindu District People\u2019s Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Princess Margaret Cancer Centre and Dalla Lana School of Public Health, Toronto, Ontario, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China"},{"name":"West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oto-Rhino-Laryngology, and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, China"},{"name":"West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"R1-20250526","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/14992027.2019.1654621","article-title":"The relationship between hearing loss and insomnia for patients with tinnitus.","volume":"59","author":"Aazh","year":"2020","journal-title":"Int J Audiol"},{"key":"R2-20250526","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1080\/14992027.2018.1537524","article-title":"Tinnitus loudness and the severity of insomnia: A mediation analysis.","volume":"58","author":"Aazh","year":"2019","journal-title":"Int J Audiol"},{"key":"R3-20250526","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.mcna.2018.06.014","article-title":"Tinnitus.","volume":"102","author":"Chari","year":"2018","journal-title":"Med Clin North 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deprivation on the association between an extended measurement of unhealthy lifestyle factors and health outcomes: A prospective analysis of the UK Biobank cohort.","volume":"3","author":"Foster","year":"2018","journal-title":"Lancet Public Health"},{"key":"R8-20250526","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/1463-1741.110287","article-title":"Association between sleep disorders, hyperacusis and tinnitus: Evaluation with tinnitus questionnaires.","volume":"15","author":"Fioretti","year":"2013","journal-title":"Noise Health"},{"key":"R9-20250526","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1053\/ajot.2000.9871","article-title":"Tinnitus and insomnia.","volume":"21","author":"Folmer","year":"2000","journal-title":"Am J Otolaryngol"},{"key":"R10-20250526","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/eurheartj\/ehz849","article-title":"Sleep patterns, genetic susceptibility, and incident cardiovascular disease: A prospective study of 385\u2009292 UK biobank participants.","volume":"41","author":"Fan","year":"2020","journal-title":"Eur Heart J"},{"key":"R11-20250526","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1007\/s00405-021-07092-x","article-title":"Prevalence of sleep impairment in patients with tinnitus: A systematic review and single-arm meta-analysis.","volume":"279","author":"Gu","year":"2022","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"R12-20250526","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/AUD.0b013e31812f71cc","article-title":"Sleep complaints in elderly tinnitus patients: A controlled study.","volume":"28","author":"H\u00e9bert","year":"2007","journal-title":"Ear Hear"},{"issue":"1 Pt 1","key":"R13-20250526","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2869.2010.00860.x","article-title":"Polysomnographic and quantitative electroencephalographic correlates of subjective sleep complaints in chronic tinnitus.","volume":"20","author":"H\u00e9bert","year":"2011","journal-title":"J Sleep Res"},{"key":"R14-20250526","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3766\/jaaa.25.1.2","article-title":"Underlying mechanisms of tinnitus: Review and clinical implications.","volume":"25","author":"Henry","year":"2014","journal-title":"J Am Acad Audiol"},{"key":"R15-20250526","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s11126-020-09794-7","article-title":"Personality and sleep evaluation of patients with tinnitus in Japan.","volume":"92","author":"Inagaki","year":"2021","journal-title":"Psychiatr Q"},{"key":"R16-20250526","doi-asserted-by":"crossref","first-page":"e0127578","DOI":"10.1371\/journal.pone.0127578","article-title":"Analysis of the prevalence and associated risk factors of tinnitus in adults.","volume":"10","author":"Kim","year":"2015","journal-title":"PloS One"},{"key":"R17-20250526","first-page":"64","article-title":"Sleep disturbances associated with tinnitus: Reduce the maximal intensity of tinnitus.","volume":"23","author":"Koning","year":"2019","journal-title":"Int Tinnitus J"},{"key":"R18-20250526","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2009.06.009","article-title":"Neural activity underlying tinnitus generation: Results from PET and fMRI.","volume":"255","author":"Lanting","year":"2009","journal-title":"Hear Res"},{"key":"R19-20250526","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/000348941112000402","article-title":"Prevalence of insomnia and impact on quality of life among community elderly subjects with tinnitus.","volume":"120","author":"Lasisi","year":"2011","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"R20-20250526","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2010.12.002","article-title":"Dysregulation of limbic and auditory networks in 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vitamin D status, sleep patterns, and the risk of incident type 2 diabetes in data from the UK biobank study.","volume":"43","author":"Wang","year":"2020","journal-title":"Diabetes Care"}],"container-title":["Ear & 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