{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:40:49Z","timestamp":1779198049048,"version":"3.51.4"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Most current video head impulse test (vHIT) systems take monocular recordings, which is sufficient to identify a peripheral vestibulopathy. Given central ocular motor abnormalities can cause dysconjugacy between the eyes, binocular vHIT may help further identify central\/dangerous lesions. Here, we examined the utility of binocular vHIT to differentiate central from peripheral vestibulopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>We enrolled three groups: healthy volunteers, consecutive patients with peripheral vestibulopathy, and consecutive patients with central vestibulopathy, respectively. All subjects underwent binocular vHIT, with vestibulo-ocular reflex (VOR) gains of each eye recorded individually. We calculated various measures of VOR gain conjugacy, including intra-class correlation coefficient (ICC), the VOR difference (VORD), and the VOR ratio between the two eyes. The absolute values of VORD (|VORD|) were compared across groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      We enrolled 48 healthy controls, 37 patients with peripheral vestibulopathy, and 17 patients with central vestibulopathy. In rightward impulses, the ICC was 0.89 in controls, 0.98 in the peripheral group, and 0.78 in the central group. In leftward impulses, the ICC was 0.76 in controls, 0.93 in the peripheral group, and 0.71 in the central group. The |VORD| was higher in the central group (mean \u00b1 SD: 0.12 \u00b1 0.16) compared to the peripheral group (0.05 \u00b1 0.04,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.02) and healthy controls (0.05 \u00b1 0.03,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      = 0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Binocular vHIT can measure the VOR gain consistency between two eyes. A finding of high-degree VOR inconsistency should increase clinical suspicion for central vestibulopathy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/aud.0000000000001663","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:27Z","timestamp":1745366427000},"page":"1247-1253","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Vestibulo-Ocular Reflex Dysconjugacy Associated With Central Cause of Dizziness"],"prefix":"10.1097","volume":"46","author":[{"given":"Anand K.","family":"Bery","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Hospital, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Chi","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Hung","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzu-Pu","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology\/Neuro-Medical Scientific Center, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan"},{"name":"Department of Neurology, School of Medicine, Tzu Chi University, Hualien, Taiwan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"R1-20260303","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1007\/s00415-017-8607-8","article-title":"Vestibulo-ocular reflex deficits with medial longitudinal fasciculus lesions.","volume":"264","author":"Aw","year":"2017","journal-title":"J Neurol"},{"key":"R2-20260303","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/jamaoto.2018.0650","article-title":"Association of the video head impulse test with improvement of dynamic balance and fall risk in patients with dizziness.","volume":"144","author":"Chang","year":"2018","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"R3-20260303","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fneur.2017.00258","article-title":"The video head impulse test.","volume":"8","author":"Halmagyi","year":"2017","journal-title":"Front Neurol"},{"key":"R4-20260303","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1161\/STROKEAHA.109.551234","article-title":"HINTS to diagnose stroke in the acute vestibular syndrome: Three-step bedside oculomotor examination more sensitive than early MRI diffusion-weighted imaging.","volume":"40","author":"Kattah","year":"2009","journal-title":"Stroke"},{"key":"R6-20260303","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fneur.2012.00021","article-title":"Plasticity during vestibular compensation: The role of saccades.","volume":"3","author":"Macdougall","year":"2012","journal-title":"Front Neurol"},{"key":"R7-20260303","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1097\/MAO.0b013e31828d676d","article-title":"Application of the video head impulse test to detect vertical semicircular canal dysfunction.","volume":"34","author":"MacDougall","year":"2013","journal-title":"Otol Neurotol"},{"key":"R8-20260303","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1212\/WNL.0b013e3181bacf85","article-title":"The video head impulse test: Diagnostic accuracy in peripheral vestibulopathy.","volume":"73","author":"MacDougall","year":"2009","journal-title":"Neurology"},{"key":"R9-20260303","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1161\/STROKEAHA.111.000033","article-title":"Quantitative video-oculography to help diagnose stroke in acute vertigo and dizziness: Toward an ECG for the eyes.","volume":"44","author":"Newman-Toker","year":"2013","journal-title":"Stroke"},{"key":"R10-20260303","doi-asserted-by":"crossref","first-page":"1153102","DOI":"10.3389\/fneur.2023.1153102","article-title":"Binocular video head impulse test: Normative data study.","volume":"14","author":"Striteska","year":"2023","journal-title":"Front Neurol"},{"key":"R11-20260303","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00221-010-2403-3","article-title":"The conjugacy of the vestibulo-ocular reflex evoked by single labyrinth stimulation in awake monkeys.","volume":"206","author":"Tang","year":"2010","journal-title":"Exp Brain Res"},{"key":"R12-20260303","doi-asserted-by":"crossref","first-page":"1222475","DOI":"10.3389\/fneur.2023.1222475","article-title":"Case report: A disconjugate pattern in video head impulse testing hints toward a central cause of acute vertigo.","volume":"14","author":"Wettstein","year":"2023","journal-title":"Front Neurol"},{"key":"R13-20260303","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/archopht.120.3.360","article-title":"Adaptations and deficits in the vestibulo-ocular reflex after third nerve palsy.","volume":"120","author":"Wong","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"R14-20260303","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1016\/S0042-6989(02)00088-3","article-title":"The vestibulo-ocular reflex in fourth nerve palsy: Deficits and adaptation.","volume":"42","author":"Wong","year":"2002","journal-title":"Vision Res"},{"key":"R15-20260303","first-page":"99","article-title":"Adaptations and deficits in the vestibulo-ocular reflex after sixth nerve palsy.","volume":"43","author":"Wong","year":"2002","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Ear &amp; Hearing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/AUD.0000000000001663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T04:00:11Z","timestamp":1772510411000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/AUD.0000000000001663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/aud.0000000000001663","relation":{},"ISSN":["1538-4667"],"issn-type":[{"value":"1538-4667","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,23]]}}}