{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:25:49Z","timestamp":1786119949521,"version":"build-2736575974"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1097\/aud.0b013e318222289f","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T04:56:21Z","timestamp":1309928181000},"page":"741-749","source":"Crossref","is-referenced-by-count":10,"title":["The Effect of Gabapentin on Gap Detection and Forward Masking in Young and Old Gerbils"],"prefix":"10.1097","volume":"32","author":[{"given":"Otto","family":"Gleich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Strutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20210128","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0197-4580(02)00008-8","article-title":"Behavioral and neural measures of auditory temporal acuity in aging humans and mice.","volume":"23","author":"Barsz","year":"2002","journal-title":"Neurobiol Aging"},{"key":"R2-7-20210128","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s101620010030","article-title":"Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model.","volume":"2","author":"Bauer","year":"2001","journal-title":"J Assoc Res Otolaryngol"},{"key":"R3-7-20210128","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/01.MLG.0000216812.65206.CD","article-title":"Effect of gabapentin on the sensation and impact of tinnitus.","volume":"116","author":"Bauer","year":"2006","journal-title":"Laryngoscope"},{"key":"R4-7-20210128","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0079-6123(07)66027-0","article-title":"Gabapentin.","volume":"66","author":"Bauer","year":"2007","journal-title":"Prog Brain Res"},{"key":"R5-7-20210128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2004.07.010","article-title":"Progress report on new antiepileptic drugs: A summary of the Seventh EILAT Conference (EILAT VII).","volume":"61","author":"Bialer","year":"2004","journal-title":"Epilepsy Res"},{"key":"R6-7-20210128","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0378-5955(96)90016-7","article-title":"Auditory evoked potentials in aged gerbils: Responses elicited by noises separated by a silent gap.","volume":"102","author":"Boettcher","year":"1996","journal-title":"Hear Res"},{"key":"R7-7-20210128","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.heares.2007.02.003","article-title":"Central neural activity in rats with tinnitus evaluated with manganese-enhanced magnetic resonance imaging (MEMRI).","volume":"228","author":"Brozoski","year":"2007a","journal-title":"Hear Res"},{"key":"R8-7-20210128","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s10162-006-0067-2","article-title":"Vigabatrin, a GABA transaminase inhibitor, reversibly eliminates tinnitus in an animal model.","volume":"8","author":"Brozoski","year":"2007b","journal-title":"J Assoc Res Otolaryngol"},{"key":"R9-7-20210128","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1242\/jeb.013581","article-title":"Inhibitory neurotransmission, plasticity and aging in the mammalian central auditory system.","volume":"211","author":"Caspary","year":"2008","journal-title":"J Exp Biol"},{"key":"R10-7-20210128","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/03610738608259430","article-title":"The gerbil: A unique model for research on aging.","volume":"12","author":"Cheal","year":"1986","journal-title":"Exp Aging Res"},{"issue":"Suppl 2","key":"R11-7-20210128","first-page":"2S3","article-title":"The aging auditory system: Anatomic and physiologic changes and implications for rehabilitation.","volume":"42","author":"Chisolm","year":"2003","journal-title":"Int J Audiol"},{"key":"R12-7-20210128","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0006-8993(01)02392-7","article-title":"Differential alterations in the distribution of voltage-gated calcium channels in aged rat cerebellum.","volume":"903","author":"Chung","year":"2001","journal-title":"Brain Res"},{"key":"R13-7-20210128","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1002\/cne.20693","article-title":"Differential distribution of voltage-gated calcium channel alpha-2 delta (\u03b12\u03b3) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia.","volume":"491","author":"Cole","year":"2005","journal-title":"J Comp Neurol"},{"key":"R14-7-20210128","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S1059-1311(02)00295-9","article-title":"Acute effects of gabapentin and pregabalin on rat forebrain cellular GABA, glutamate, and glutamine concentrations.","volume":"12","author":"Errante","year":"2003","journal-title":"Seizure"},{"key":"R15-7-20210128","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0920-1211(02)00034-7","article-title":"Gabapentin and vigabatrin increase GABA in the human neocortical slice.","volume":"49","author":"Errante","year":"2002","journal-title":"Epilepsy Res"},{"key":"R16-7-20210128","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/1568026053386872","article-title":"Voltage gated ion channels: Targets for anticonvulsant drugs.","volume":"5","author":"Errington","year":"2005","journal-title":"Curr Top Med Chem"},{"key":"R17-7-20210128","first-page":"183","article-title":"Auditory temporal processing in elderly listeners.","volume":"7","author":"Fitzgibbons","year":"1996","journal-title":"J Am Acad Audiol"},{"key":"R18-7-20210128","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1121\/1.2739409","article-title":"Age-related differences in discrimination of an interval separating onsets of successive tone bursts as a function of interval duration.","volume":"122","author":"Fitzgibbons","year":"2007","journal-title":"J Acoust Soc Am"},{"key":"R19-7-20210128","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0378-5955(97)00006-3","article-title":"Speech recognition in noise and presbycusis: Relations to possible neural mechanisms.","volume":"106","author":"Frisina","year":"1997","journal-title":"Hear Res"},{"key":"R20-7-20210128","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1097\/00001756-200310060-00024","article-title":"Boosting GABA improves impaired auditory temporal resolution in the gerbil.","volume":"14","author":"Gleich","year":"2003","journal-title":"Neuroreport"},{"key":"R21-7-20210128","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.heares.2006.06.014","article-title":"A quantitative analysis of psychometric functions for different auditory tasks in gerbils.","volume":"220","author":"Gleich","year":"2006","journal-title":"Hear Res"},{"key":"R22-7-20210128","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.heares.2006.11.001","article-title":"Forward masking in gerbils: The effect of age.","volume":"223","author":"Gleich","year":"2007a","journal-title":"Hear Res"},{"key":"R23-7-20210128","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.heares.2006.12.002","article-title":"Temporal integration in the gerbil: The effects of age, hearing loss and temporally unmodulated and modulated speech-like masker noises.","volume":"224","author":"Gleich","year":"2007b","journal-title":"Hear Res"},{"key":"R24-7-20210128","article-title":"Signal Detection Theory and Psychophysics.","author":"Green","year":"1974"},{"key":"R25-7-20210128","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ana.410390203","article-title":"Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis.","volume":"39","author":"Gurney","year":"1996","journal-title":"Ann Neurol"},{"key":"R26-7-20210128","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0378-5955(02)00454-9","article-title":"Behavioral and evoked-potential thresholds in young and old Mongolian gerbils (Meriones unguiculatus).","volume":"171","author":"Hamann","year":"2002","journal-title":"Hear Res"},{"key":"R27-7-20210128","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10162-003-3041-2","article-title":"Behaviorally determined gap-detection thresholds in young and old Mongolian gerbils (Meriones unguiculatus).","volume":"5","author":"Hamann","year":"2004","journal-title":"J Assoc Res Otolaryngol"},{"key":"R28-7-20210128","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neulet.2004.05.048","article-title":"Age-related changes in the levels of voltage-dependent calcium channels and other synaptic proteins in rat brain cortices.","volume":"366","author":"Iwamoto","year":"2004","journal-title":"Neurosci Lett"},{"key":"R29-7-20210128","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0014-2999(87)90457-2","article-title":"One to three day dose intervals during subchronic treatment of epileptic gerbils with gamma-vinyl GABA: Anticonvulsant efficacy and alterations in regional brain GABA levels.","volume":"143","author":"L\u00f6scher","year":"1987","journal-title":"Eur J Pharmacol"},{"key":"R30-7-20210128","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0304-3940(91)90249-S","article-title":"Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain.","volume":"128","author":"L\u00f6scher","year":"1991","journal-title":"Neurosci Lett"},{"key":"R31-7-20210128","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/ana.410390114","article-title":"The effect of gabapentin on brain gamma-aminobutyric acid in patients with epilepsy.","volume":"39","author":"Petroff","year":"1996","journal-title":"Ann Neurol"},{"key":"R32-7-20210128","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1528-1157.2000.tb00227.x","article-title":"Effects of gabapentin on brain GABA, homocarnosine, and pyrrolidinone in epilepsy patients.","volume":"41","author":"Petroff","year":"2000","journal-title":"Epilepsia"},{"key":"R33-7-20210128","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1001\/archotol.133.4.390","article-title":"Relief of idiopathic subjective tinnitus: Is gabapentin effective?","volume":"133","author":"Piccirillo","year":"2007","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"R34-7-20210128","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrn1430","article-title":"The neurobiology of antiepileptic drugs.","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat Rev Neurosci"},{"key":"R35-7-20210128","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1121\/1.408403","article-title":"Gap detection and the precedence effect in young and old adults.","volume":"95","author":"Schneider","year":"1994","journal-title":"J Acoust Soc Am"},{"key":"R36-7-20210128","first-page":"1","article-title":"Gabapentin and tinnitus relief.","volume":"14","author":"Shulman","year":"2008","journal-title":"Int Tinnitus J"},{"key":"R37-7-20210128","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.coph.2005.11.003","article-title":"The mechanisms of action of gabapentin and pregabalin.","volume":"6","author":"Sills","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"R38-7-20210128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02805968","article-title":"The antiepileptic agent gabapentin (Neurontin) possesses anxiolytic-like and antinociceptive actions that are reversed by D-serine.","volume":"127","author":"Singh","year":"1996","journal-title":"Psychopharmacology (Berl)"},{"key":"R39-7-20210128","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1121\/1.418205","article-title":"Age-related changes in temporal gap detection.","volume":"101","author":"Snell","year":"1997","journal-title":"J Acoust Soc Am"},{"key":"R40-7-20210128","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1121\/1.428446","article-title":"Relationships among age-related differences in gap detection and word recognition.","volume":"107","author":"Snell","year":"2000","journal-title":"J Acoust Soc Am"},{"key":"R41-7-20210128","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0168-0102(00)00212-1","article-title":"Age-related changes in the subtypes of voltage-dependent calcium channels in rat brain cortical synapses.","volume":"39","author":"Tanaka","year":"2001","journal-title":"Neurosci Res"},{"key":"R42-7-20210128","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0920-1211(97)00084-3","article-title":"A summary of mechanistic hypotheses of gabapentin pharmacology.","volume":"29","author":"Taylor","year":"1998","journal-title":"Epilepsy Res"},{"key":"R43-7-20210128","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1203\/PDR.0b013e318174e70e","article-title":"Gabapentin neuroprotection and seizure suppression in immature mouse brain ischemia.","volume":"64","author":"Traa","year":"2008","journal-title":"Pediatr Res"},{"key":"R44-7-20210128","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s10162-007-0101-z","article-title":"Sensorineural hearing loss and neural correlates of temporal acuity in the inferior colliculus of the C57BL\/6 mouse.","volume":"9","author":"Walton","year":"2008","journal-title":"J Assoc Res Otolaryngol"},{"key":"R45-7-20210128","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1159\/000046129","article-title":"Modulation of presbycusis: Current status and future directions.","volume":"6","author":"Willott","year":"2001","journal-title":"Audiol Neurootol"},{"key":"R46-7-20210128","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/01.mao.0000235967.53474.93","article-title":"Treatment of tinnitus with gabapentin: A pilot study.","volume":"28","author":"Witsell","year":"2007","journal-title":"Otol Neurotol"},{"key":"R47-7-20210128","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1177\/014556130108000211","article-title":"Gabapentin for the treatment of tinnitus: A case report.","volume":"80","author":"Zapp","year":"2001","journal-title":"Ear Nose Throat J"}],"container-title":["Ear & Hearing"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/AUD.0b013e318222289f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:33:35Z","timestamp":1786044815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00003446-201111000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/aud.0b013e318222289f","relation":{},"ISSN":["0196-0202"],"issn-type":[{"value":"0196-0202","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}