{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:37:46Z","timestamp":1787009866183,"version":"build-2736575974"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,3]]},"abstract":"\n Purpose of review<\/jats:title>\n Gout is a common debilitating form of arthritis and despite our extensive knowledge on the pathogenesis its prevalence is still rising quickly. In the current review, we provide a concise overview of recent discoveries in factors tuning the inflammatory response to soluble uric acid and monosodium urate crystals.<\/jats:p>\n <\/jats:sec>\n \n Recent findings<\/jats:title>\n It appears that soluble uric acid has a much larger role to play than just being a risk factor for gout. It may have widespread consequences for systemic inflammation and the development of metabolic syndrome. Additionally, a specific gout-related gut microbiome might not only provide us with a new diagnostic tool, but also highlights possible new therapeutic targets. Furthermore, several recent publications further elucidated the roles of mitochondrial dysfunction, production of reactive oxygen species, autophagy, and AMP-dependent protein kinase in monosodium urate-induced NLRP3 inflammasome activation. Finally, neutrophils have been shown to be involved in both the promotion and resolution of gouty inflammation. A new alpha-1-antitrypsin fusion protein may limit the proinflammatory effects of neutrophil-derived serine proteases.<\/jats:p>\n <\/jats:sec>\n \n Summary<\/jats:title>\n Together, these studies provide us with many new insights in the pathogenesis of gout, important new treatment targets, and a rationale to further study the role of soluble uric acid in inflammatory diseases.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/bor.0000000000000366","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T05:14:21Z","timestamp":1481346861000},"page":"163-170","source":"Crossref","is-referenced-by-count":54,"title":["Factors modulating the inflammatory response in acute gouty arthritis"],"prefix":"10.1097","volume":"29","author":[{"given":"Maartje C.","family":"Cleophas","sequence":"first","affiliation":[{"name":"Department of Internal Medicine"},{"name":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania O.","family":"Cri\u015fan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"},{"name":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands"},{"name":"Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo A.B.","family":"Joosten","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine"},{"name":"Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands"},{"name":"Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, 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