{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:09:32Z","timestamp":1786118972533,"version":"build-2736575974"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1097\/bor.0b013e3283060a8c","type":"journal-article","created":{"date-parts":[[2008,8,12]],"date-time":"2008-08-12T03:07:22Z","timestamp":1218510442000},"page":"595-600","source":"Crossref","is-referenced-by-count":28,"title":["Antiphospholipid syndrome in children"],"prefix":"10.1097","volume":"20","author":[{"given":"Tadej","family":"Av\u010din","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20210128","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJMra002974","article-title":"The antiphospholipid syndrome","volume":"346","author":"Levine","year":"2002","journal-title":"N Engl J Med"},{"key":"R2-15-20210128","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2249.2004.02497.x","article-title":"Antiphospholipid syndrome: multiple mechanisms","volume":"136","author":"Mackworth-Young","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"R3-15-20210128","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s11926-007-0031-0","article-title":"Mechanisms of aPL-mediated thrombosis: effects of aPL on endothelium and platelets","volume":"9","author":"Vega-Ostertag","year":"2007","journal-title":"Curr Rheumatol Rep"},{"key":"R4-15-20210128","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11926-007-0033-y","article-title":"Role of complement in antiphospholipid antibody-mediated thrombosis","volume":"9","author":"O'Neil","year":"2007","journal-title":"Curr Rheumatol Rep"},{"key":"R5-15-20210128","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.rdc.2006.05.005","article-title":"Pediatric antiphospholipid syndrome","volume":"32","author":"Cimaz","year":"2006","journal-title":"Rheum Dis Clin North Am"},{"key":"R6-15-20210128","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.rdc.2007.07.001","article-title":"Antiphospholipid syndrome in pediatrics","volume":"33","author":"Ravelli","year":"2007","journal-title":"Rheum Dis Clin North Am"},{"key":"R7-15-20210128","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1177\/0961203307079036","article-title":"Antiphospholipid antibodies in pediatric systemic lupus erythematosus and the antiphospholipid syndrome","volume":"16","author":"Av\u010din","year":"2007","journal-title":"Lupus"},{"key":"R8-15-20210128","first-page":"169","article-title":"Pediatric antiphospholipid syndrome","author":"Av\u010din","year":"2008"},{"key":"R9-15-20210128","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1053\/j.semperi.2007.07.011","article-title":"Venous thromboembolism in the neonatal period","volume":"31","author":"Beardsely","year":"2007","journal-title":"Semin Perinatol"},{"key":"R10-15-20210128","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1053\/j.semperi.2007.06.001","article-title":"Prothrombotic risk factors in the evaluation and management of perinatal stroke","volume":"31","author":"Grabowski","year":"2007","journal-title":"Semin Perinatol"},{"key":"R11-15-20210128","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/0961203307079039","article-title":"Infant perinatal thrombosis and antiphospholipid antibodies: a review","volume":"16","author":"Boffa","year":"2007","journal-title":"Lupus"},{"key":"R12-15-20210128","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/rheumatology\/kem011","article-title":"Neonatal antiphospholipid syndrome associated with heterozygous methylentetrahydrofolate reductase C677T and prothrombin G20210A gene mutations","volume":"46","author":"Paro-Panjan","year":"2007","journal-title":"Rheumatology"},{"key":"R13-15-20210128","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.pediatrneurol.2007.04.007","article-title":"Risk factors for perinatal arterial stroke: a study of 60 mother\u2013child pairs","volume":"37","author":"Curry","year":"2007","journal-title":"Pediatr Neurol"},{"key":"R15-15-20210128","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/art.23311","article-title":"Neuropsychological development of children born to patients with antiphospholipid syndrome","volume":"59","author":"Nacinovich","year":"2008","journal-title":"Arthritis Rheum"},{"key":"R16-15-20210128","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0022-510X(98)00027-6","article-title":"Anti\u03b22 glycoprotein I antibodies bind to central nervous system","volume":"156","author":"Caronti","year":"1998","journal-title":"J Neurol Sci"},{"key":"R17-15-20210128","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1191\/0961203303lu503oa","article-title":"Endothelium and the brain in CNS lupus","volume":"12","author":"Meroni","year":"2003","journal-title":"Lupus"},{"key":"R18-15-20210128","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1191\/0961203302lu255oa","article-title":"Behavioral and cognitive deficits occur only after prolonged exposure of mice to antiphospholipid antibodies","volume":"11","author":"Shrot","year":"2002","journal-title":"Lupus"},{"key":"R19-15-20210128","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1191\/0961203303lu409oa","article-title":"Neuronal-binding antibodies from patients with antiphospholipid syndrome induce cognitive deficits following intrathecal passive transfer","volume":"12","author":"Shoenfeld","year":"2003","journal-title":"Lupus"},{"key":"R20-15-20210128","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1055\/s-2006-939533","article-title":"Anticardiolipin and antibeta2 glycoprotein I antibodies in infants born to mothers with antiphospholipid antibody-positive autoimmune disease: a follow-up study","volume":"23","author":"Motta","year":"2006","journal-title":"Am J Perinatol"},{"key":"R21-15-20210128","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/rheumatology\/40.5.565","article-title":"Anticardiolipin and anti\u03b22 glycoprotein I antibodies in sera of 61 apparently healthy children at regular preventive visits","volume":"40","author":"Av\u010din","year":"2001","journal-title":"Rheumatology"},{"key":"R22-15-20210128","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1093\/intimm\/dxf043","article-title":"Anti\u03b22 glycoprotein I antibodies in children with atopic dermatitis","volume":"14","author":"Ambro\u017ei\u010d","year":"2002","journal-title":"Int Immunol"},{"key":"R23-15-20210128","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1538-7836.2006.01753.x","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome","volume":"4","author":"Miyakis","year":"2006","journal-title":"J Thromb Haemost"},{"key":"R24-15-20210128","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/art.22360","article-title":"Antiphospholipid syndrome and recurrent thrombosis in children","volume":"55","author":"Berkun","year":"2006","journal-title":"Arthritis Rheum"},{"key":"R25-15-20210128","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/MBC.0b013e32809cc95a","article-title":"Antiphospholipid antibodies in Turkish children with thrombosis","volume":"18","author":"Tavil","year":"2007","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R27-15-20210128","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1002\/art.10187","article-title":"Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients","volume":"46","author":"Cervera","year":"2002","journal-title":"Arthritis Rheum"},{"key":"R28-15-20210128","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/0961203307077108","article-title":"Antiphospholipid syndrome in Latin American patients: clinical and immunologic characteristics and comparison with European patients","volume":"16","author":"Garcia-Carrasco","year":"2007","journal-title":"Lupus"},{"key":"R29-15-20210128","first-page":"1873","article-title":"Neuropsychiatric manifestations in pediatric systemic lupus erythematosus and association with antiphospholipid antibodies","volume":"33","author":"Harel","year":"2006","journal-title":"J Rheumatol"},{"key":"R30-15-20210128","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/art.23334","article-title":"A follow-up study of antiphospholipid antibodies and associated neuropsychiatric manifestations in 137 children with systemic lupus erythematosus","volume":"59","author":"Av\u010din","year":"2008","journal-title":"Arthritis Rheum"},{"key":"R31-15-20210128","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/ajmg.a.31774","article-title":"Chorea associated with antiphospholipid antibodies in a patient with Kabuki syndrome","volume":"143","author":"Gidwani","year":"2007","journal-title":"Am J Med Genet A"},{"key":"R32-15-20210128","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/mds.21657","article-title":"Clinical and positron emission tomography findings of chorea associated with primary antiphospholipid antibody syndrome","volume":"22","author":"Wu","year":"2007","journal-title":"Mov Disord"},{"key":"R33-15-20210128","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1191\/0961203303lu411oa","article-title":"Outcome of primary antiphospholipid syndrome in childhood","volume":"12","author":"Gattorno","year":"2003","journal-title":"Lupus"},{"key":"R34-15-20210128","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1177\/0961203307077993","article-title":"Primary antiphospholipid syndrome as the forerunner of systemic lupus erythematosus","volume":"16","author":"Tarr","year":"2007","journal-title":"Lupus"},{"key":"R35-15-20210128","first-page":"1674","article-title":"Managing antiphospholipid antibodies and antiphospholipid syndrome in children","volume":"91","author":"Kamat","year":"2006","journal-title":"Haematologica"},{"key":"R36-15-20210128","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/art.23109","article-title":"A systematic review of secondary thromboprophylaxis in patients with antiphospholipid antibodies","volume":"57","author":"Ruiz-Irastorza","year":"2007","journal-title":"Arthritis Rheum"},{"key":"R37-15-20210128","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1182\/blood-2005-05-2048","article-title":"Predictive value of persistent versus transient antiphospholipid antibody subtypes for the risk of thrombotic events in pediatric patients with systemic lupus erythematosus","volume":"106","author":"Male","year":"2005","journal-title":"Blood"},{"key":"R38-15-20210128","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/rheumatology\/kem335","article-title":"Paediatric systemic lupus erythematosus: prognostic impact of antiphospholipid antibodies","volume":"47","author":"Descloux","year":"2008","journal-title":"Rheumatology"},{"key":"R39-15-20210128","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/art.10072","article-title":"Risk factors for damage in childhood-onset systemic lupus erythematosus: cumulative disease activity and medication use predict disease damage","volume":"46","author":"Brunner","year":"2002","journal-title":"Arthritis Rheum"},{"key":"R40-15-20210128","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/rheumatology\/keh384","article-title":"Predictors of neuropsychiatric damage in systemic lupus erythematosus: data from the Maryland lupus cohort","volume":"43","author":"Mikdashi","year":"2004","journal-title":"Rheumatology"},{"key":"R41-15-20210128","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1136\/ard.2004.025759","article-title":"Validation of the preliminary criteria for the classification of catastrophic antiphospholipid syndrome","volume":"64","author":"Cervera","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"R42-15-20210128","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/s00247-006-0183-5","article-title":"Catastrophic antiphospholipid syndrome and pulmonary embolism in a 3-year-old child","volume":"36","author":"Olivier","year":"2006","journal-title":"Pediatr Radiol"},{"key":"R43-15-20210128","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s10067-006-0251-0","article-title":"Catastrophic antiphospholipid syndrome in a 7-year-old girl","volume":"26","author":"Park","year":"2007","journal-title":"Clin Rheumatol"},{"key":"R44-15-20210128","first-page":"1793","article-title":"Microangiopathic antiphospholipid-associated syndromes revisited \u2013 new concepts relating to antiphospholipid antibodies and syndromes","volume":"34","author":"Asherson","year":"2007","journal-title":"J Rheumatol"},{"key":"R46-15-20210128","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1136\/ard.2005.045443","article-title":"Infectious origin of the antiphospholipid syndrome","volume":"65","author":"Shoenfeld","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"R47-15-20210128","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s11926-007-0034-x","article-title":"Antiphospholipid antibodies in response to infection","volume":"9","author":"Av\u010din","year":"2007","journal-title":"Curr Rheumatol Rep"},{"key":"R48-15-20210128","doi-asserted-by":"crossref","first-page":"e292","DOI":"10.1542\/peds.2006-1340","article-title":"Mycoplasma pneumoniae, splenic infarct, and transient antiphospholipid antibodies: a new association?","volume":"119","author":"Witmer","year":"2007","journal-title":"Pediatrics"},{"key":"R49-15-20210128","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ppul.20739","article-title":"Mycoplasma pneumonia and pulmonary embolism in a child due to acquired prothrombotic factors","volume":"43","author":"Brown","year":"2008","journal-title":"Pediatr Pulmonol"},{"key":"R50-15-20210128","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.braindev.2005.11.002","article-title":"Cerebrovascular disease and varicella in children","volume":"28","author":"Losurdo","year":"2006","journal-title":"Brain Dev"},{"key":"R51-15-20210128","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1203\/00006450-200109000-00009","article-title":"The varicella-autoantibody syndrome","volume":"50","author":"Josephson","year":"2001","journal-title":"Pediatr Res"},{"key":"R52-15-20210128","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000077315","article-title":"Purpura fulminans in a child as a complication of chickenpox infection","volume":"208","author":"Campanelli","year":"2004","journal-title":"Dermatology"},{"key":"R53-15-20210128","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1542\/peds.2005-0433","article-title":"Lemierre's and Lemierre's-like syndromes in children: survival and thromboembolic outcomes","volume":"116","author":"Goldenberg","year":"2005","journal-title":"Pediatrics"}],"container-title":["Current Opinion in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/BOR.0b013e3283060a8c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:12:34Z","timestamp":1786036354000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002281-200809000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/bor.0b013e3283060a8c","relation":{},"ISSN":["1040-8711"],"issn-type":[{"value":"1040-8711","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}