{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:53:59Z","timestamp":1787061239302,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1097\/bor.0b013e32832ca41c","type":"journal-article","created":{"date-parts":[[2009,5,25]],"date-time":"2009-05-25T03:22:57Z","timestamp":1243221777000},"page":"369-373","source":"Crossref","is-referenced-by-count":44,"title":["Denosumab update"],"prefix":"10.1097","volume":"21","author":[{"given":"E Michael","family":"Lewiecki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20210128","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1001\/jama.285.6.785","article-title":"Osteoporosis prevention, diagnosis, and therapy","volume":"285","author":"Klibanski","year":"2001","journal-title":"J Am Med Assoc"},{"key":"R3-11-20210128","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporosis-related fractures in the United States, 2005\u20132025","volume":"22","author":"Burge","year":"2007","journal-title":"J Bone Miner Res"},{"key":"R4-11-20210128","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.0105-2896.2005.00338.x","article-title":"Rheumatic diseases: the effects of inflammation on bone","volume":"208","author":"Walsh","year":"2005","journal-title":"Immunol Rev"},{"key":"R5-11-20210128","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.berh.2007.05.005","article-title":"Economic consequences of established rheumatoid arthritis and its treatment","volume":"21","author":"Kavanaugh","year":"2007","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"R6-11-20210128","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1359\/JBMR.040305","article-title":"A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women","volume":"19","author":"Bekker","year":"2004","journal-title":"J Bone Miner Res"},{"key":"R7-11-20210128","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1161\/01.RES.0000149165.99974.12","article-title":"Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin","volume":"95","author":"Collin-Osdoby","year":"2004","journal-title":"Circ Res"},{"key":"R8-11-20210128","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"R9-11-20210128","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1001\/jama.292.4.490","article-title":"Clinical implications of the osteoprotegerin\/RANKL\/RANK system for bone and vascular diseases","volume":"292","author":"Hofbauer","year":"2004","journal-title":"J Am Med Assoc"},{"key":"R10-11-20210128","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.coph.2005.06.005","article-title":"Osteoprotegerin and RANKL regulate bone resorption, density, geometry and strength","volume":"5","author":"Kostenuik","year":"2005","journal-title":"Curr Opin Pharmacol"},{"key":"R11-11-20210128","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1056\/NEJMoa044459","article-title":"Denosumab in postmenopausal women with low bone mineral density","volume":"354","author":"McClung","year":"2006","journal-title":"N Engl J Med"},{"key":"R12-11-20210128","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1359\/jbmr.070809","article-title":"Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low bone mineral density","volume":"22","author":"Lewiecki","year":"2007","journal-title":"J Bone Miner Res"},{"key":"R13-11-20210128","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.bone.2008.04.007","article-title":"Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trial","volume":"43","author":"Miller","year":"2008","journal-title":"Bone"},{"issue":"Suppl 1","key":"R14-11-20210128","first-page":"S295","article-title":"Phase 2 study of denosumab (AMG 162) in postmenopausal women: subanalyses and supplemental safety","volume":"20","author":"Cohen","year":"2005","journal-title":"J Bone Miner Res"},{"key":"R15-11-20210128","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1210\/jc.2007-2814","article-title":"Effects of denosumab on bone mineral density and bone turnover in postmenopausal women","volume":"93","author":"Bone","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"R16-11-20210128","first-page":"S80","article-title":"A phase III study of the effects of denosumab on vertebral, nonvertebral, and hip fracture in women with osteoporosis: results from the FREEDOM trial","volume":"23","author":"Cummings","year":"2008","journal-title":"J Bone Miner Res"},{"key":"R18-11-20210128","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1359\/jbmr.0809010","article-title":"Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial","volume":"24","author":"Brown","year":"2009","journal-title":"J Bone Miner Res"},{"issue":"Suppl 1","key":"R19-11-20210128","first-page":"S473","article-title":"Effects of denosumab vs. alendronate on bone mineral density (BMD), bone turnover markers (BTM), and safety in women previously treated with alendronate","volume":"23","author":"Kendler","year":"2008","journal-title":"J Bone Miner Res"},{"key":"R20-11-20210128","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1002\/art.23417","article-title":"Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial","volume":"58","author":"Cohen","year":"2008","journal-title":"Arthritis Rheum"},{"key":"R21-11-20210128","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/jps.20178","article-title":"Antibody pharmacokinetics and pharmacodynamics","volume":"93","author":"Lobo","year":"2004","journal-title":"J Pharm Sci"},{"key":"R22-11-20210128","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1002\/jps.20125","article-title":"Pharmacokinetic aspects of biotechnology products","volume":"93","author":"Tang","year":"2004","journal-title":"J Pharm Sci"},{"key":"R23-11-20210128","first-page":"S293","article-title":"The pharmacokinetics of denosumab (AMG 162) following various multiple subcutaneous dosing regimens in postmenopausal women with low bone mass","volume":"20","author":"Peterson","year":"2005","journal-title":"J Bone Miner Res"},{"key":"R24-11-20210128","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"R25-11-20210128","first-page":"1387","article-title":"OMERACT rheumatoid arthritis magnetic resonance imaging studies. Summary of OMERACT 6 MR imaging module","volume":"30","author":"McQueen","year":"2003","journal-title":"J Rheumatol"},{"key":"R26-11-20210128","first-page":"261","article-title":"How to read radiographs according to the Sharp\/van der Heijde method","volume":"27","author":"van der Heijde","year":"2000","journal-title":"J Rheumatol"}],"container-title":["Current Opinion in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/BOR.0b013e32832ca41c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:49:39Z","timestamp":1786038579000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002281-200907000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/bor.0b013e32832ca41c","relation":{},"ISSN":["1040-8711"],"issn-type":[{"value":"1040-8711","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}