{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T05:42:08Z","timestamp":1693287728847},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9]]},"abstract":"\n Objectives:<\/jats:title>\n Avascular necrosis (AVN) of the femoral head is a devastating complication following fixation of femoral neck fractures in younger adults. In this study, we investigate the prognostic utility of disuse osteopenia.<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Retrospective study.<\/jats:p>\n <\/jats:sec>\n \n Setting:<\/jats:title>\n Three academic Level 1 trauma centers.<\/jats:p>\n <\/jats:sec>\n \n Patients:<\/jats:title>\n One hundred twenty patients younger than 60 years treated for a femoral neck fracture.<\/jats:p>\n <\/jats:sec>\n \n Intervention:<\/jats:title>\n N\/A.<\/jats:p>\n <\/jats:sec>\n \n Main Outcome Measures:<\/jats:title>\n The presence of sclerosis or osteopenia, compared to the contralateral femoral head, was measured 6 weeks from injury both subjectively and using a novel radiographic measure, the relative density ratio (RDR). The outcome measure was radiographic development of AVN.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The presence of relative sclerosis was associated with AVN and overall treatment failure. Patients with subjective relative sclerosis had a 12.6 (95% confidence interval, 2.9\u201361.3; P<\/jats:italic> < 0.001) times higher odds of developing AVN. Multiple logistic regression showed that for every 0.10 increase in the RDR, there was a 5.2 increase in the odds (95% confidence interval, 2.1\u201326.9; P<\/jats:italic> = 0.009) of developing AVN. Patients with an RDR of \u22651.2 have an 80% probability of AVN, whereas those with an RDR \u22640.8 have a <1% probability of developing AVN.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Disuse osteopenia detected on 6-week radiographs is a favorable prognostic sign following fixation of femoral neck fractures. Patients who have relative sclerosis of the femoral head at 6-week follow-up are at a higher risk of developing AVN.<\/jats:p>\n <\/jats:sec>\n \n Level of Evidence:<\/jats:title>\n Diagnostic Level III. See Instructions for Authors for a complete description of levels of evidence.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/bot.0000000000000635","type":"journal-article","created":{"date-parts":[[2016,5,28]],"date-time":"2016-05-28T16:30:51Z","timestamp":1464453051000},"page":"496-502","source":"Crossref","is-referenced-by-count":2,"title":["Is Disuse Osteopenia a Favorable Prognostic Sign After Femoral Neck Fracture?"],"prefix":"10.1097","volume":"30","author":[{"given":"Beverlie L.","family":"Ting","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Harvard Medical School Orthopedic Trauma Initiative, Brigham and Women's Hospital, Boston, MA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilyn","family":"Heng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Harvard Medical School Orthopedic Trauma Initiative, Massachusetts General Hospital, Boston, MA; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Vrahas","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Harvard Medical School Orthopedic Trauma Initiative, Massachusetts General Hospital, Boston, MA; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward K.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Harvard Medical School Orthopedic Trauma Initiative, Beth Israel Deaconess Medical Center, Boston, MA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchel B.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Harvard Medical School Orthopedic Trauma Initiative, Brigham and Women's Hospital, Boston, MA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Harvard Medical School Orthopedic Trauma Initiative, Brigham and Women's Hospital, Boston, MA;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230828","first-page":"238","article-title":"Hip fractures in adults younger than 50 years of age. 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