{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T20:54:24Z","timestamp":1780952064289,"version":"3.54.1"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n            <jats:title>Objectives:<\/jats:title>\n            <jats:p>This multicenter study was designed to evaluate whether tibia fracture nonunions treated with exchange nailing proceed to union faster with dynamically- versus statically-locked nails, or with fibular osteotomy versus no fibular osteotomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Design:<\/jats:title>\n            <jats:p>Retrospective, chart-review, multicenter study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Setting:<\/jats:title>\n            <jats:p>Multicenter review of 6 level 1 trauma centers.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patients\/Participants:<\/jats:title>\n            <jats:p>Patients who had a tibia fracture treated with an intramedullary nail that progressed to nonunion, and were subsequently treated with exchange nailing, were identified. All patients that met inclusion criteria and subsequently progressed to union were included in the study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Intervention:<\/jats:title>\n            <jats:p>Patients underwent tibial exchange nailing to repair nonunions, with screws in either a dynamically- or statically-locked configuration with or without fibular osteotomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Main Outcome Measures:<\/jats:title>\n            <jats:p>The primary outcome measure was a comparison of time to healing of tibial nonunion comparing different screw configurations and fibular osteotomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Fifty-two patients underwent an exchange nail procedure and their outcomes were used for the primary analysis. Patients with dynamically-locked nails proceeded to union 7.9 months after revision surgery compared with 7.3 months for those with statically-locked nails, but this was not statistically significant (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.68). Patients with fibular osteotomy proceeded to union 2.9 months faster than those without fibular osteotomy, and this trended toward significance (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.067). Obese patients healed on average 8.8 months after surgery compared with 6.8 months for nonobese patients (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.27). Closed fractures healed after 6.4 months compared with 7.7 months for open fractures (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.40).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>There was no significant difference in time to union between patients who had a dynamic screw configuration compared with a static screw configuration for their exchange nail. Patients who underwent fibular osteotomy proceeded to union faster than those without an osteotomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Level of Evidence:<\/jats:title>\n            <jats:p>Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/bot.0000000000000647","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T16:30:02Z","timestamp":1469032202000},"page":"622-626","source":"Crossref","is-referenced-by-count":10,"title":["Does Screw Configuration or Fibular Osteotomy Decrease Healing Time in Exchange Tibial Nailing?"],"prefix":"10.1097","volume":"30","author":[{"given":"Bryan","family":"Abadie","sequence":"first","affiliation":[{"name":"Wake Forest School of Medicine, Winston-Salem, NC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Leas","sequence":"additional","affiliation":[{"name":"Carolinas Medical Center, Charlotte, NC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Cannada","sequence":"additional","affiliation":[{"name":"St. Louis University, St. Louis, MO;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Malm","sequence":"additional","affiliation":[{"name":"St. Louis University, St. Louis, MO;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Morwood","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, NC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Howes","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, NC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Zura","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, NC;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Healy","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Avery","sequence":"additional","affiliation":[{"name":"University of North Carolina at Chapel Hill, Chapel Hill, NC; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Schlatterer","sequence":"additional","affiliation":[{"name":"Atlanta Medical Center, Atlanta, GA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna N.","family":"Miller","sequence":"additional","affiliation":[{"name":"Wake Forest School of Medicine, Winston-Salem, NC;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230828","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1471-2474-9-91","article-title":"Study to prospectively evaluate reamed intramedually nails in patients with tibial fractures (S.P.R.I.N.T.): study rationale and design","volume":"9","author":"Bhandari","year":"2008","journal-title":"BMC Musculoskelet Disord."},{"key":"R2-20230828","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.injury.2010.02.020","article-title":"Systematic review shows lowered risk of nonunion after reamed nailing in patients with closed tibial shaft fractures","volume":"41","author":"Lam","year":"2010","journal-title":"Injury"},{"key":"R3-20230828","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/BOT.0b013e3182249fad","article-title":"Murine model of oligotrophic tibial nonunion","volume":"25","author":"Hu","year":"2011","journal-title":"J Orthop Trauma."},{"issue":"suppl 1","key":"R4-20230828","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1097\/BOT.0b013e3181d2efaf","article-title":"Ultrasound for fracture healing: current evidence","volume":"24","author":"Watanabe","year":"2010","journal-title":"J Orthop Trauma."},{"key":"R5-20230828","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1302\/0301-620X.77B3.7744925","article-title":"Exchange intramedullary nailing. 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