{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:17:13Z","timestamp":1792898233530,"version":"4.5.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To determine whether opioid use disorders (OUDs) are associated with adverse perioperative outcomes in patients undergoing surgical fixation for proximal femur fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The National Hospital Discharge Survey was queried to identify patients surgically treated for proximal femur fractures between 1990 and 2007. Patients were grouped into those with a diagnosis of OUD, nonopioid drug use disorder, or neither. Demographic information and comorbidities were included in univariable and multivariable analyses to identify independent risk factors for perioperative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 8154 patients with a diagnosis of drug use disorder and 4704 patients with a diagnosis of OUD were identified from a cohort of 4,732,165 surgically treated proximal femur fractures. Patients with OUD were significantly younger (46 vs. 79), and a significantly smaller proportion of them had medical comorbidities (21.9% vs. 60.2%) when compared with the no drug misuse cohort. Patients with OUD had significantly more medical complications (51.1% vs. 26.8%), mechanical complications (3% vs. 0.3%), and adverse events (55% vs. 39.7%) when compared with the no drug misuse group. OUD had higher odds for leaving against medical advice [odds ratio (OR) 12.868, range 10.7771\u201315.375], for any adverse event (OR 4.107, range 3.869\u20134.360), and for mortality (OR 1.744, range 1.250\u20132.433) when compared with nondrug misusers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Despite being younger and with significantly less medical comorbidities, patients with OUD have higher odds for adverse events, leaving against medical advice, and mortality after surgical treatment of a hip fracture.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/bot.0000000000001118","type":"journal-article","created":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T21:55:12Z","timestamp":1516485312000},"page":"238-244","source":"Crossref","is-referenced-by-count":28,"title":["Opioid Use Disorders Are Associated With Perioperative Morbidity and Mortality in the Hip Fracture Population"],"prefix":"10.1097","volume":"32","author":[{"given":"Spencer","family":"Summers","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, University of Miami, Miami, FL; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, University of Miami, Miami, FL; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dustin","family":"Massel","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, University of Miami, Miami, FL; 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