{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T23:33:58Z","timestamp":1787700838297,"version":"build-2784847793"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>To assess the impact of direct oral anticoagulant (DOAC) intake compared with Coumadin (COU) in patients suffering hip fractures (HFs).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Design:<\/jats:title>\n            <jats:p>Retrospective cohort analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Setting:<\/jats:title>\n            <jats:p>Level 1 Trauma Center.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Intervention:<\/jats:title>\n            <jats:p>Timing of surgical hip fixation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Patients:<\/jats:title>\n            <jats:p>Three-hundred twenty patients 65 years of age or older with isolated HF were enrolled into the study: 207 (64.7%) without any antithrombotic therapy (no-ATT), 59 (18.4%) on COU, and 54 (16.9%) on DOACs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Main Outcome Measurements:<\/jats:title>\n            <jats:p>Time to surgery, blood loss, mortality, hospital length of stay, red blood cell transfusion, use of reversal agents, and Charlson Comorbidity Index.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Patients on COU and DOACs had a higher Charlson Comorbidity Index compared with the no-ATT group (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.0001). Despite the fact that significantly more patients received reversal agents in the COU group compared with DOAC medication (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.0001), percentage of transfused patients were similar (54.2% vs. 53.7%). Time to surgery was significantly shorter in the no-ATT group when compared with DOAC patients (12\u201329.5 hours, respectively). No difference in postoperative hemorrhage, intensive care unit length of stay, and mortality was observed between groups.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>DOAC medication in HF patients caused long elapse time until surgical repair. We found no evidence of higher bleeding rates in HF patients on DOACs compared with COUs. Earlier HF fixation might be indicated in DOAC patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Level of Evidence:<\/jats:title>\n            <jats:p>Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/bot.0000000000001329","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T23:07:39Z","timestamp":1538521659000},"page":"e8-e13","source":"Crossref","is-referenced-by-count":59,"title":["Impact of Direct Oral Anticoagulants in Patients With Hip Fractures"],"prefix":"10.1097","volume":"33","author":[{"given":"Martin","family":"Bruckbauer","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Center Salzburg, Academic Teaching Hospital, Paracelsus Medical University, Salzburg, Austria;"},{"name":"Paracelsus Medical University, Salzburg, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Prexl","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Center Salzburg, Academic Teaching Hospital, Paracelsus Medical University, Salzburg, Austria;"},{"name":"Paracelsus Medical University, Salzburg, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Voelckel","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Center Salzburg, Academic Teaching Hospital, Paracelsus Medical University, Salzburg, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, Paracelsus Medical University, Salzburg, Austria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Grottke","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, RWTH Aachen University Hospital, Aachen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Maegele","sequence":"additional","affiliation":[{"name":"Department for Trauma and Orthopaedic Surgery, Cologne-Merheim Medical Center (CMMC), University Witten\/Herdecke (UW\/H), Campus Cologne-Merheim, Cologne, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Sch\u00f6chl","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care Medicine, AUVA Trauma Center Salzburg, Academic Teaching Hospital, Paracelsus Medical University, Salzburg, Austria;"},{"name":"Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, AUVA Trauma Research Center, Vienna, Austria."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230828","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1097\/TA.0000000000001453","article-title":"Managing hip fracture and lower limb surgery in the emergency setting: potential role of non-vitamin K antagonist oral anticoagulants","volume":"82","author":"Fisher","year":"2017","journal-title":"J Trauma Acute Care Surg."},{"key":"R2-20230828","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/BF01623184","article-title":"Hip fractures in the elderly: a world-wide projection","volume":"2","author":"Cooper","year":"1992","journal-title":"Osteoporos Int."},{"key":"R3-20230828","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.thromres.2015.09.017","article-title":"The impact of oral anticoagulation on time to surgery in patients hospitalized with hip fracture","volume":"136","author":"Tran","year":"2015","journal-title":"Thromb Res."},{"key":"R4-20230828","doi-asserted-by":"crossref","first-page":"e4120","DOI":"10.1097\/MD.0000000000004120","article-title":"Risk factors for the effect of anticoagulant and antiplatelet agents on perioperative blood loss following proximal femoral fractures","volume":"95","author":"Akaoka","year":"2016","journal-title":"Med Baltim."},{"key":"R5-20230828","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.thromres.2011.09.013","article-title":"Use of anticoagulants in elderly patients","volume":"129","author":"Bauersachs","year":"2012","journal-title":"Thromb Res."},{"key":"R6-20230828","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.amjmed.2015.05.044","article-title":"National trends in ambulatory oral anticoagulant use","volume":"128","author":"Barnes","year":"2015","journal-title":"Am J Med."},{"key":"R7-20230828","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1053\/j.seminhematol.2014.03.005","article-title":"Direct oral anticoagulants\u2013pharmacology, drug interactions, and side effects","volume":"51","author":"Dempfle","year":"2014","journal-title":"Semin Hematol."},{"key":"R8-20230828","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s11239-017-1506-0","article-title":"Benefits and harms of 4-factor prothrombin complex concentrate for reversal of vitamin K antagonist associated bleeding: a systematic review and meta-analysis","volume":"44","author":"Brekelmans","year":"2017","journal-title":"J Thromb Thrombolysis."},{"key":"R9-20230828","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1056\/NEJMoa1707278","article-title":"Idarucizumab for dabigatran reversal\u2014full cohort analysis","volume":"377","author":"Pollack","year":"2017","journal-title":"N Engl J Med."},{"key":"R10-20230828","first-page":"575","article-title":"Direct oral anticoagulants in emergency trauma admissions","volume":"113","author":"Maegele","year":"2016","journal-title":"Dtsch Arztebl Int."},{"key":"R11-20230828","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.2106\/JBJS.O.00229","article-title":"The American Academy of Orthopaedic Surgeons evidence-based guideline on management of hip fractures in the elderly","volume":"97","author":"Brox","year":"2015","journal-title":"J Bone Jt Surg Am."},{"key":"R12-20230828","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/BF03016088","article-title":"Is operative delay associated with increased mortality of hip fracture patients? 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