{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:57:25Z","timestamp":1782287845902,"version":"3.54.5"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>To assess whether the fixation method and vitamin D supplementation affect the risk of patient-important outcomes within 12 months of injury in nongeriatric femoral neck fracture patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Design:<\/jats:title>\n            <jats:p>A pilot factorial randomized controlled trial.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Setting:<\/jats:title>\n            <jats:p>Fifteen North American clinical sites.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Participants:<\/jats:title>\n            <jats:p>Ninety-one adults 18\u201360 years of age with a femoral neck fracture requiring surgical fixation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Intervention:<\/jats:title>\n            <jats:p>Participants were randomized to a surgical intervention (sliding hip screw or cancellous screws) and a vitamin D intervention (vitamin D<jats:sub>3<\/jats:sub> 4000 IU daily vs. placebo for 6 months).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Main Outcome Measurements:<\/jats:title>\n            <jats:p>The primary clinical outcome was a composite of patient-important complications (reoperation, femoral head osteonecrosis, severe femoral neck malunion, and nonunion). Secondary outcomes included fracture-healing complications and radiographic fracture healing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Eighty-six participants with a mean age of 41 years were included. We found no statistically significant difference in the risk of patient-important outcomes between the surgical treatment arms (hazard ratio 0.90, 95% confidence interval 0.40\u20132.02, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.80) and vitamin D supplementation treatment arms (hazard ratio 0.96, 95% confidence interval 0.42\u20132.18, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.92).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>These pilot trial results continue to describe the results of current fixation implants, inform the challenges of improving outcomes in this fracture population, and may guide future vitamin D trials to improve healing outcomes in young fracture populations. Although the pilot trial was not adequately powered to detect treatment effects, publishing these results may facilitate future meta-analyses on this topic.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Level of Evidence:<\/jats:title>\n            <jats:p>Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/bot.0000000000001773","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T21:25:05Z","timestamp":1596057905000},"page":"524-532","source":"Crossref","is-referenced-by-count":15,"title":["Fixation Using Alternative Implants for the Treatment of Hip Fractures (FAITH-2): The Clinical Outcomes of a Multicenter 2 \u00d7 2 Factorial Randomized Controlled Pilot Trial in Young Femoral Neck Fracture Patients"],"prefix":"10.1097","volume":"34","author":[{"given":"Gerard P.","family":"Slobogean","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Sprague","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada;"},{"name":"Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Bzovsky","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taryn","family":"Scott","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lehana","family":"Thabane","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Heels-Ansdell","sequence":"additional","affiliation":[{"name":"Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert V.","family":"O'Toole","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Howe","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg E.","family":"Gaski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista M.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Viskontas","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, University of British Columbia, New Westminster, BC, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauri","family":"Zomar","sequence":"additional","affiliation":[{"name":"Division of Orthopaedics, Fraser Health Authority, New Westminster, BC, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J.","family":"Della Rocca","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Missouri, Columbia, MO."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan N.","family":"O'Hara","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Bhandari","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD;"},{"name":"Division of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"FAITH-2 Investigators*","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230828","doi-asserted-by":"crossref","first-page":"204","DOI":"10.5312\/wjo.v5.i3.204","article-title":"Management of femoral neck fractures in the young patient: a critical analysis review","volume":"5","author":"Pauyo","year":"2014","journal-title":"World J Orthop."},{"key":"R2-20230828","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s40814-019-0458-x","article-title":"Fixation using alternative implants for the treatment of hip fractures (FAITH-2): design and rationale for a pilot multi-centre 2\u2009\u00d7\u20092 factorial randomized controlled trial in young femoral neck fracture patients","volume":"5","author":"Slobogean","year":"2019","journal-title":"Pilot Feasibility Stud."},{"issue":"suppl 2","key":"R3-20230828","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2106\/00004623-200200002-00002","article-title":"The Swedish total hip replacement register","volume":"84","author":"Malchau","year":"2002","journal-title":"J Bone Joint Surg."},{"key":"R4-20230828","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.injury.2014.11.028","article-title":"Management of young femoral neck fractures: is there a consensus","volume":"46","author":"Slobogean","year":"2015","journal-title":"Injury."},{"key":"R5-20230828","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/BOT.0000000000000455","article-title":"What is the role of vitamin D supplementation in acute fracture patients? 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