{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T05:35:24Z","timestamp":1768282524958,"version":"3.49.0"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n            <jats:title>Objective:<\/jats:title>\n            <jats:p>To characterize the patient population with substance-related found-down extremity compartment syndrome (FDECS) and report on their treatment and outcome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Data Source:<\/jats:title>\n            <jats:p>This systematic review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Articles in English language were identified by searching 3 online databases, EMBASE, PubMed Publisher, and Cochrane Central, in September 2019.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Study Selection:<\/jats:title>\n            <jats:p>Studies involving substance-related FDECS were included. Exclusion criteria were as follows: patient age &lt;18 years, not original studies, no full text available, technical reports, traumatic acute extremity compartment syndrome, chronic exertional compartment syndrome, and vascular acute extremity compartment syndrome.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Data Extraction:<\/jats:title>\n            <jats:p>There were 61 studies included with 166 cases of FDECS. Two investigators screened and extracted data independently according to a standardized template. Disagreements were addressed by an attempt to reach a consensus, and involvement of a third reviewer. Studies were quality assessed with \u201cQuality Assessment tool for Case Series Studies.\u201d<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Data Synthesis:<\/jats:title>\n            <jats:p>Descriptive statistics were reported using Excel.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion:<\/jats:title>\n            <jats:p>Substance-related FDECS is often occurring in young adults. Data from this review found that most of the patients were already diagnosed with substance use disorders and\/or psychiatric disorders. There should be a high index of suspicion of FDECS in patients presenting after prolonged immobilization.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Level of Evidence:<\/jats:title>\n            <jats:p>Prognostic Level IV. 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