{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:37:56Z","timestamp":1787009876230,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7,13]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>To determine whether Fluoxetine, prescribed by orthopaedic providers during the immediate post-traumatic period, can lessen post-traumatic stress symptoms in survivors of traumatic musculoskeletal injuries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Design<\/jats:italic>\n                      : Non-Blinded Prospective Randomized Clinical Trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Single Academic Level 1 Trauma Center.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patient Selection Criteria:<\/jats:title>\n                    <jats:p>\n                      From July 2021 to December 2023, orthopaedic surgical patients admitted for a high-energy musculoskeletal trauma (injuries not resulting from a ground level fall or less) were randomized to receive 9 months of Fluoxetine (Prozac\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) or Placebo (Calcium).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures and comparisons:<\/jats:title>\n                    <jats:p>Outcomes were collected five times over the course of one year (2 weeks, 6 weeks, 3 months, 6 months, and 12 months). Patient-reported outcome measures evaluated depression (Beck Depression Inventory, BDI-II), anxiety (Beck Anxiety Inventory, BAI), Post-Traumatic Stress Disorder (PTSD) (PTSD Scale-Self report for DSM-5, PSS-SR), sleep (Pittsburgh Sleep Quality Index, PSQI), pain ( Pain, Enjoyment, General Activity Scale, PEG), and social enjoyment (PROMIS \u2013 Ability to participate Social, and PROMIS \u2013 Social Isolation ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      The two groups (Fluoxetine = 33, Calcium = 35) were similar in terms of age (Fluoxetine = 43.5 years (SD 15.8, range = 18-73), Calcium = 40.3 years (SD 17.7, range18-70 )) and sex (Fluoxetine =14 females, Calcium = 15 females). Subjects randomized to fluoxetine showed an improvement in PTSD symptoms over time (estimate = -0.2, 95%: -0.4, -0.0; with negative numbers indicating lessening symptoms), while those randomized to calcium exhibited little to no change (estimate = 0.1, 95%: -0.1, 0.3). Additionally, subjects in the fluoxetine group (estimate = -0.1, 95% CI: -0.1, -0.0, negative numbers indicating a decrease in pain) showed a significant improvement in pain over time, whereas the calcium group showed no significant change (estimate = -0.0, 95% CI: -0.0, 0.0). There were no significant changes over time in BDI scores (F\n                      <jats:sub>1,159<\/jats:sub>\n                      = 0.0, p = 0.9), BAI scores (F\n                      <jats:sub>1,169.4<\/jats:sub>\n                      = 0.0, p = 0.9), or PROMIS measure Social Isolation (F\n                      <jats:sub>1,142.9<\/jats:sub>\n                      = 0.5, p = 0.5).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Nine months of fluoxetine following a traumatic musculoskeletal injury decreased the severity of post-traumatic stress symptoms and pain throughout the recovery period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence:<\/jats:title>\n                    <jats:p>Level II<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/bot.0000000000003243","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:03:47Z","timestamp":1783965827000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Nine Months of Fluoxetine Aids in the Reduction of Posttraumatic Stress Symptoms following a Traumatic Musculoskeletal Injury: A Randomized Controlled Trial"],"prefix":"10.1097","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-8054","authenticated-orcid":false,"given":"M","family":"Pazik","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery & Sports Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Vasilopoulos","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery & Sports Medicine, University of Florida, Gainesville, FL"},{"name":"Department of Anesthesiology, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"de Faria","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dv","family":"Rijo","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery & Sports Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mb","family":"Horodyski","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery & Sports Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ca","family":"Mathews","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery & Sports Medicine, University of Florida, Gainesville, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Journal of Orthopaedic Trauma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/BOT.0000000000003243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:03:47Z","timestamp":1783965827000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/BOT.0000000000003243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,13]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1097\/bot.0000000000003243","relation":{},"ISSN":["0890-5339","1531-2291"],"issn-type":[{"value":"0890-5339","type":"print"},{"value":"1531-2291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,13]]}}}