{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:38:22Z","timestamp":1787009902575,"version":"build-2736575974"},"reference-count":80,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Leukemia is a common hematological malignancy with overall poor prognosis. Novel therapies are needed to improve the outcome of leukemia patients. Cholesterol metabolism reprogramming is a featured alteration in leukemia. Many metabolic-related genes and metabolites are essential to the progress and drug resistance of leukemia. Exploring potential therapeutical targets related to cholesterol homeostasis is a promising area. This review summarized the functions of cholesterol and its derived intermediate metabolites, and also discussed potential agents targeting this metabolic vulnerability in leukemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/bs9.0000000000000016","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T11:20:09Z","timestamp":1577964009000},"page":"44-49","source":"Crossref","is-referenced-by-count":22,"title":["The role of cholesterol metabolism in leukemia"],"prefix":"10.1097","volume":"1","author":[{"given":"Liang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huien","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinya","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqiu","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Jinan University, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Hematology, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"(10)","key":"R1-20230726","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1182\/blood-2014-02-554204","article-title":"A distinct glucose metabolism signature of acute myeloid leukemia with prognostic 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