{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:18:04Z","timestamp":1780085884146,"version":"3.54.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>The RNA editing enzyme ADAR1 has been shown to be an essential molecule for hematopoietic cell differentiation, embryonic development, and regulation of immune responses. Here, we present evidence in a T-cell-specific gene knockout mouse model that ADAR1 is required for early T cell development. Loss of ADAR1 led to cell death of the progenitors at the double negative stage and prevented T cell maturation in the thymus. Furthermore, ADAR1 deletion in pre-T cells preferentially affected TCR\u03b2-expressing cells causing TCR\u03b2 positive cell depletion. Interruption of IFN signaling occurred in the premature T cells, indicating a role of IFN signaling in the survival of TCR\u03b2-expressing cells regulated by ADAR1. This study demonstrated an essential role for the RNA editing enzyme ADAR1 as a potential regulator for T-cell fate determination during clonal selection, which, in turn, contributes to immunologic homeostasis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/bs9.0000000000000039","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T16:04:21Z","timestamp":1604937861000},"page":"27-32","source":"Crossref","is-referenced-by-count":8,"title":["RNA editing enzyme ADAR1 is required for early T cell development"],"prefix":"10.1097","volume":"2","author":[{"given":"Richard","family":"Xufeng","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA"},{"name":"HumanCells Biosciences, Sunnyvale, CA 94089, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daibang","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Immunology, College of Basic Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA"},{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingde","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"(1\u20133)","key":"R1-20230726","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12026-008-8035-z","article-title":"Progenitor migration to the thymus and T cell lineage commitment","volume":"42","author":"Sambandam","year":"2008","journal-title":"Immunol Res"},{"key":"R2-20230726","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.immunol.23.021704.115737","article-title":"Molecular genetics of T cell development","volume":"23","author":"Rothenberg","year":"2005","journal-title":"Annu Rev 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