{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:52:27Z","timestamp":1793371947984,"version":"4.5.0"},"reference-count":88,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>Platelets play vital roles in hemostasis, inflammation, and vascular biology. Platelets are also active participants in the immune responses. As vertebrates, zebrafish have a highly conserved hematopoietic system in the developmental, cellular, functional, biochemical, and genetic levels with mammals. Thrombocytes in zebrafish are functional homologs of mammalian platelets. Here, we summarized thrombocyte development, function, and related research techniques in zebrafish, and reviewed available zebrafish models of platelet-associated disorders, including congenital amegakaryocytic thrombocytopenia, inherited thrombocytopenia, essential thrombocythemia, and blood coagulation disorders such as gray platelet syndrome. These elegant zebrafish models and methods are crucial for understanding the molecular and genetic mechanisms of thrombocyte development and function, and provide deep insights into related human disease pathophysiology and drug development.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/bs9.0000000000000043","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T21:03:17Z","timestamp":1604955797000},"page":"44-49","source":"Crossref","is-referenced-by-count":13,"title":["Zebrafish for thrombocytopoiesis- and hemostasis-related researches and disorders"],"prefix":"10.1097","volume":"2","author":[{"given":"Panpan","family":"Meng","sequence":"first","affiliation":[{"name":"Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou 510006, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou 510006, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou 510006, P.R. China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,5,9]]},"reference":[{"issue":"(7446)","key":"R1-20230726","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature12111","article-title":"The zebrafish reference genome sequence and its relationship to the human genome","volume":"496","author":"Howe","year":"2013","journal-title":"Nature"},{"issue":"(43)","key":"R2-20230726","doi-asserted-by":"crossref","first-page":"7233","DOI":"10.1038\/sj.onc.1207943","article-title":"The \u2019definitive\u2019 (and \u2019primitive\u2019) guide to zebrafish hematopoiesis","volume":"23","author":"Davidson","year":"2004","journal-title":"Oncogene"},{"issue":"(3)","key":"R3-20230726","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1053\/j.seminhematol.2010.03.001","article-title":"Megakaryopoiesis","volume":"47","author":"Geddis","year":"2010","journal-title":"Semin 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