{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T18:22:42Z","timestamp":1790101362609,"version":"4.0.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Abstract<\/jats:title><jats:p>Sickle cell disease (SCD) affects nearly 100,000 people in the United States of America and the sickle gene is present in approximately 8% of black Americans. Among Africans, the prevalence of sickle cell trait (heterozygosity) is as high as 30%. While SCD occurs among varying racial and ethnic groups, it is more commonly prevalent in individuals of African or African-American descent. This inherited blood disorder causes varying symptoms and complications among affected children and adults and early diagnosis and treatment are essential to help reduce mortality rates. Because there is no cure for SCD, management is vital to survival. Hence, there are different approaches in use to aid those living with SCD; thus, this paper provides insight into the current methods that are implemented in the management and maintenance of this disease.<\/jats:p><\/jats:sec>","DOI":"10.1097\/bs9.0000000000000056","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T21:01:07Z","timestamp":1604955667000},"page":"109-116","source":"Crossref","is-referenced-by-count":11,"title":["Current modalities of sickle cell disease management"],"prefix":"10.1097","volume":"2","author":[{"given":"Adekunle","family":"Sanyaolu","sequence":"first","affiliation":[{"name":"Federal Ministry of Health, Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ejoke","family":"Agiri","sequence":"additional","affiliation":[{"name":"Saint James School of Medicine, Anguilla, 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