{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T16:03:12Z","timestamp":1772035392944,"version":"3.50.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Study Design:<\/jats:title>\n                    <jats:p>Single-center, retrospective cohort study (level\u202fIII).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study evaluates alignment changes and outcomes after C5\u2013C7 ACDF and examines whether the degree of segmental correction is associated with reoperation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The C5\u20136 and C6\u20137 segments are frequently affected in cervical degenerative disc disease due to their mobility and transitional anatomy. Two-level anterior cervical discectomy and fusion (ACDF) is commonly performed at these levels. Although global cervical alignment restoration has been associated with improved functional outcomes and reduced adjacent-segment disease, the specific impact of postoperative lordotic correction at C5\u2013C7 on clinical measures and revision risk remains poorly defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cohort study was conducted at a single institution. Patients undergoing 2-level C5\u2013C7 ACDF were evaluated for demographics, sagittal alignment parameters, and complications through 1 year postoperatively. Multivariate logistic regression, controlling for age, sex, Charlson comorbidity index (CCI), and baseline cervical deformity, was used to assess the association between segmental correction and reoperation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 92 patients underwent C5\u2013C7 ACDF. Mean age was 51.7 years, 57% were female, and mean CCI was 0.5. Significant improvements were observed in C2\u2013C7 lordosis (2.4\u20137.3 deg.), fused segment alignment (\u20134.3 to 2.1 deg.), and T1-CL (23.8\u201320.9 deg.) (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.01). Average correction at fused levels was 6.5 degrees (SD 7.4 deg.). Overall, 12% (11\/92) underwent reoperation. Inadequate correction increased reoperation odds 7.2-fold (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.028).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>C5\u2013C7 ACDF yields significant sagittal correction. However, limited segmental improvement may increase reoperation risk. Achieving sufficient correction is important to optimize outcomes and reduce complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/bsd.0000000000002002","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T15:01:16Z","timestamp":1772031676000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Loss of Lordosis at C5\u20137 Following 2-Level Anterior Cervical Discectomy and Fusion Is Associated With Subsequent Reoperations"],"prefix":"10.1097","author":[{"given":"Manjot","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Orthopedics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Perez-Albela","sequence":"additional","affiliation":[{"name":"Department of 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