{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:14:19Z","timestamp":1786119259068,"version":"build-2736575974"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1097\/bsd.0b013e31817eee55","type":"journal-article","created":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T03:23:17Z","timestamp":1244085797000},"page":"361-366","source":"Crossref","is-referenced-by-count":22,"title":["Comparison of Cardiovascular Parameters Between Patients With Ossification of Posterior Longitudinal Ligament and Patients With Cervical Spondylotic Myelopathy"],"prefix":"10.1097","volume":"22","author":[{"given":"Masaki","family":"Kishiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-Ichi","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Numasawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanichiro","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Toh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20210204","first-page":"425","article-title":"The ossification of the posterior longitudinal ligament of the spine (OPLL)","volume":"55","year":"1981","journal-title":"Nippon Seikeigeka Gakkai Zasshi"},{"key":"R2-10-20210204","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s00296-004-0529-y","article-title":"Morbidity and mortality of hospitalized patients with diffuse idiopathic skeletal hyperostosis","volume":"26","author":"Mader","year":"2005","journal-title":"Rheumatol Int"},{"key":"R3-10-20210204","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s00296-005-0588-8","article-title":"Body mass index and blood glucose: correlations with serum insulin, growth hormone, and insulin-like growth factor-1 levels in patients with diffuse idiopathic skeletal hyperostosis (DISH)","volume":"26","author":"Denko","year":"2006","journal-title":"Rheumatol Int"},{"key":"R4-10-20210204","first-page":"411","article-title":"Clinical and radiological study of ossification of the anterior longitudinal ligament in the cervical spine","volume":"31","author":"Miyazawa","year":"2003","journal-title":"No Shinkei Geka"},{"key":"R5-10-20210204","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1097\/00007632-199310000-00007","article-title":"Increase of serum growth hormone-binding protein in patients with ossification of the posterior longitudinal ligament of the spine","volume":"18","author":"Ikegawa","year":"1993","journal-title":"Spine"},{"key":"R6-10-20210204","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/0026-0495(84)90209-9","article-title":"Ossification of the paravertebral ligaments: a frequent complication of hypoparathyroidism","volume":"33","author":"Okazaki","year":"1984","journal-title":"Metabolism"},{"key":"R7-10-20210204","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/pgmj.53.617.167","article-title":"Paravertebral and peripheral ligamentous ossification: an unusual association of hypoparathyroidism","volume":"53","author":"Adams","year":"1977","journal-title":"Postgrad Med J"},{"key":"R9-10-20210204","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/00007632-200405010-00011","article-title":"High body mass index after age 20 and diabetes mellitus are independent risk factors for ossification of the posterior longitudinal ligament of the spine in Japanese subjects: a case-control study in multiple hospitals","volume":"29","author":"Kobashi","year":"2004","journal-title":"Spine"},{"key":"R10-10-20210204","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.2106\/00004623-200110000-00013","article-title":"Insulin secretory response is positively associated with the extent of ossification of the posterior longitudinal ligament of the spine","volume":"83-A","author":"Akune","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"R11-10-20210204","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1097\/00007632-199611010-00013","article-title":"Ligamentous ossification of the cervical spine in the late middle-aged Japanese men. Its relation to body mass index and glucose metabolism","volume":"21","author":"Shingyouchi","year":"1996","journal-title":"Spine"},{"key":"R12-10-20210204","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF00404070","article-title":"Medial arterial calcification in the feet of diabetic patients and matched non-diabetic control subjects","volume":"36","author":"Young","year":"1993","journal-title":"Diabetologia"},{"key":"R13-10-20210204","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.0954-6820.1984.tb08739.x","article-title":"Diabetic macroangiopathy. Medial calcifications, narrowing, rugosities, stiffness, norepinephrine depletion and reduced blood flow capacity in the leg arteries","volume":"687","author":"Neubauer","year":"1984","journal-title":"Acta Med Scand Suppl"},{"key":"R14-10-20210204","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00223-006-0147-7","article-title":"Pathophysiological Role of Endothelin in Ectopic Ossification of Human Spinal Ligaments Induced by Mechanical Stress","volume":"49","author":"Iwasawa","year":"2006","journal-title":"Calcif Tissue Int"},{"key":"R15-10-20210204","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/00024720-200608000-00005","article-title":"Postoperative changes at the lower end of cervical laminoplasty: for preservation of the C7 spinous process in laminoplasty","volume":"19","author":"Takeuchi","year":"2006","journal-title":"J Spinal Disord Tech"},{"key":"R16-10-20210204","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1097\/01.brs.0000186332.66490.ba","article-title":"Axial symptoms after cervical laminoplasty with C3 laminectomy compared with conventional C3-C7 laminoplasty: a modified laminoplasty preserving the semispinalis cervicis inserted into axis","volume":"30","author":"Takeuchi","year":"2005","journal-title":"Spine"},{"key":"R17-10-20210204","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.blo.0000160710.11991.33","article-title":"Anatomic study of the semispinalis cervicis for reattachment during laminoplasty","volume":"436","author":"Takeuchi","year":"2005","journal-title":"Clin Orthop Relat Res"},{"key":"R18-10-20210204","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/sj.sc.3101881","article-title":"Immunohistochemistry of symptomatic hypertrophy of the posterior longitudinal ligament with special reference to ligamentous ossification","volume":"44","author":"Song","year":"2005","journal-title":"Spinal Cord"},{"key":"R19-10-20210204","first-page":"167","article-title":"Histochemical and immunohistochemical study on the skin of patients with ossification of the posterior longitudinal ligament in the cervical spine","volume":"9","author":"Imamura","year":"1995","journal-title":"In Vivo"},{"key":"R20-10-20210204","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00003086-199902000-00003","article-title":"Pathology of ossification of the posterior longitudinal ligament and ligamentum flavum","volume":"359","author":"Ono","year":"1999","journal-title":"Clin Orthop Relat Res"},{"key":"R21-10-20210204","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s00223-002-0021-1","article-title":"Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament","volume":"74","author":"Iwasaki","year":"2004","journal-title":"Calcif Tissue Int"},{"key":"R22-10-20210204","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S8756-3282(03)00204-7","article-title":"Uniaxial cyclic stretch induces osteogenic differentiation and synthesis of bone morphogenetic proteins of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments","volume":"33","author":"Tanno","year":"2003","journal-title":"Bone"},{"key":"R23-10-20210204","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1086\/378593","article-title":"Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine","volume":"73","author":"Tanaka","year":"2003","journal-title":"Am J Hum Genet"},{"key":"R24-10-20210204","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1359\/jbmr.2002.17.1.128","article-title":"Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine","volume":"17","author":"Furushima","year":"2002","journal-title":"J Bone Miner Res"},{"key":"R25-10-20210204","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1097\/01.BRS.0000068245.27017.9F","article-title":"Association between polymorphism of the transforming growth factor-beta1 gene with the radiologic characteristic and ossification of the posterior longitudinal ligament","volume":"28","author":"Kawaguchi","year":"2003","journal-title":"Spine"},{"key":"R26-10-20210204","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1097\/01.brs.0000182318.47343.6d","article-title":"COL6A1, the candidate gene for ossification of the posterior longitudinal ligament, is associated with diffuse idiopathic skeletal hyperostosis in Japanese","volume":"30","author":"Tsukahara","year":"2005","journal-title":"Spine"},{"key":"R27-10-20210204","doi-asserted-by":"crossref","first-page":"8523","DOI":"10.1074\/jbc.M409442200","article-title":"The promyelotic leukemia zinc finger promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1","volume":"280","author":"Ikeda","year":"2005","journal-title":"J Biol Chem"},{"key":"R28-10-20210204","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1254\/jphs.FMJ05004X5","article-title":"Current Topics in Pharmacological Research on Bone Metabolism: Promyelotic Leukemia Zinc Finger (PLZF) and Tumor Necrosis Factor-alpha-Stimulated Gene 6 (TSG-6) Identified by Gene Expression Analysis Play Roles in the Pathogenesis of Ossification of the Posterior Longitudinal Ligament","volume":"100","author":"Inoue","year":"2006","journal-title":"J Pharmacol Sci"},{"key":"R29-10-20210204","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1097\/00007632-200209010-00009","article-title":"Possible roles of CTGF\/Hcs24 in the initiation and development of ossification of the posterior longitudinal ligament","volume":"27","author":"Yamamoto","year":"2002","journal-title":"Spine"},{"key":"R30-10-20210204","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1124\/jpet.102.047142","article-title":"Role of prostaglandin I2 in the gene expression induced by mechanical stress in spinal ligament cells derived from patients with ossification of the posterior longitudinal ligament","volume":"305","author":"Ohishi","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"R31-10-20210204","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1254\/jphs.FMJ05004X4","article-title":"Current topics in pharmacological research on bone metabolism: molecular basis of ectopic bone formation induced by mechanical stress","volume":"100","author":"Furukawa","year":"2006","journal-title":"J Pharmacol Sci"},{"key":"R32-10-20210204","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1359\/jbmr.2001.16.5.948","article-title":"Functional impact of human collagen alpha2(XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine","volume":"16","author":"Maeda","year":"2001","journal-title":"J Bone Miner Res"},{"key":"R33-10-20210204","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1359\/jbmr.1999.14.4.500","article-title":"Human retinoic X receptor beta: complete genomic sequence and mutation search for ossification of posterior longitudinal ligament of the spine","volume":"14","author":"Numasawa","year":"1999","journal-title":"J Bone Miner Res"},{"key":"R34-10-20210204","first-page":"1109","article-title":"Twy mouse and ossification of the posterior longitudinal ligament of the spine (OPLL)","volume":"12","author":"Yamazaki","year":"2002","journal-title":"Clin Calcium"},{"key":"R36-10-20210204","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/956","article-title":"Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine","volume":"19","author":"Okawa","year":"1998","journal-title":"Nat Genet"},{"key":"R37-10-20210204","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s004390050993","article-title":"Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)","volume":"104","author":"Nakamura","year":"1999","journal-title":"Hum Genet"},{"key":"R39-10-20210204","first-page":"445","article-title":"Effect of transforming growth factor-beta on fibroblasts in ossification of the posterior longitudinal ligament","volume":"10","author":"Inaba","year":"1996","journal-title":"In vivo"},{"key":"R40-10-20210204","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/jcb.20652","article-title":"The control of chondrogenesis","volume":"97","author":"Goldring","year":"2006","journal-title":"J Cell Biochem"},{"key":"R41-10-20210204","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jemt.20088","article-title":"Histochemical evidence of the initial chondrogenesis and osteogenesis in the periosteum of a rib fractured model: implications of osteocyte involvement in periosteal chondrogenesis","volume":"64","author":"Li","year":"2004","journal-title":"Microsc Res Tech"},{"key":"R42-10-20210204","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1148\/119.3.559","article-title":"Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH)","volume":"119","author":"Resnick","year":"1976","journal-title":"Radiology"},{"key":"R43-10-20210204","first-page":"193","article-title":"Diffuse idiopathic skeletal hyperostosis (DISH): is it of vascular aetiology?","volume":"18","author":"el Miedany","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"R44-10-20210204","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1097\/01.brs.0000250307.78987.6b","article-title":"Long-term results of expansive open-door laminoplasty for cervical myelopathy--average 14-year follow-up study","volume":"31","author":"Chiba","year":"2006","journal-title":"Spine"},{"key":"R45-10-20210204","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3171\/spi.2005.3.3.0198","article-title":"Long-term results after expansive open-door laminoplasty for the segmental-type of ossification of the posterior longitudinal ligament of the cervical spine: a comparison with nonsegmental-type lesions","volume":"3","author":"Ogawa","year":"2005","journal-title":"J Neurosurg Spine"}],"container-title":["Journal of Spinal Disorders &amp; Techniques"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/BSD.0b013e31817eee55","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:53:24Z","timestamp":1786038804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00024720-200907000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/bsd.0b013e31817eee55","relation":{},"ISSN":["1536-0652"],"issn-type":[{"value":"1536-0652","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}